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- W304844186 abstract "Frameshifting-stimulating pseudoknots, referred to as pseudoknots unless specified otherwise, exhibit classic H-type pseudoknot-folds with two stacked stems (S1 and S2) and two loops (L1 and L2) (Fig. 1A). Structural elements responsible for the stability and the integrity of the pse udoknots include quasi-continuous base-stacking in S1 and S2 and an extensive S1-L2 triplex interaction.Structural diversity among pseudoknots appears to be one of major culprits for various vi ral systems to achieve different -1RFS efficiencies optimized to their own needs. The pseu-doknots in BWYV (beet western yellow virus) and SRV-1 (simian retrovirus-1) provide an interesting instance for the structural diversity. BWYV and other luteoviral pseudoknots, which mediate P1-P2 production through -1RFS, are relatively small and tightly folded with a characteristically very short S2 (3 base pairs) (Fig. 1A). These luteoviral pseudoknots produce considerable degrees of -1RFS and show a strong sequence preference in both L1 and L2 for efficient -1RFS." @default.
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- W304844186 date "2009-02-20" @default.
- W304844186 modified "2023-09-22" @default.
- W304844186 title "Structural Elements Contributing to Efficient -1 Ribosomal Frameshifting in BWYV Pseudoknot" @default.
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- W304844186 doi "https://doi.org/10.5012/bkcs.2009.30.2.509" @default.
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