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- W3048444607 abstract "Background Objectives Methods To obtain information about the involvement of tumour necrosis factor-alpha (TNF-a) in the pathophysiology of SLE this cytokine was measured, by an enzyme linked immunosorbent assay, in sera from 109 patients (pts) with systemic lupus erythematosus (SLE) (44 men and 65 women). The results were compared with 20 healthy subjects. The mean level of TNF-alpha was 84,4+ 43,2 pg/ml in males (0–859 pg/ml) and 11+7,4 pg/ml in females (0–192,2 pg/ml). The difference between male and female cohorts was significant (p Results TNF-alpha was found positive (more than 3s.d. above the mean in normal controls) in 17 females (26%), 36 males (81,8%) in pts with SLE compared to 1 person (5%) of normal controls (p Conclusion There are differences between the level, the clinical value of TNF-alpha in male and female cohorts of pts with SLE. The measurement of TNF-alpha maybe a useful tool for monitoring disease activity, in the male cohort especially." @default.
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- W3048444607 date "2001-06-01" @default.
- W3048444607 modified "2023-09-24" @default.
- W3048444607 title "AB0014 Tumour necrosis factor-alpha in patients with systemic lupus erythematosus" @default.
- W3048444607 doi "https://doi.org/10.1136/annrheumdis-2001.813" @default.
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