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- W3048448153 abstract "Abstract The reduction‐sensitive amphiphilic polymer chol‐SS‐F68‐SS‐Chol (F68‐CDEC. chol, SS and F68 represent cholesterol, disulfide bond and Pluronic F68, respectively) was easily synthesized by two steps of esterification reactions. The self‐assembly behavior of the polymer was studied by fluorescence spectrophotometry, dynamic light scattering and TEM. Impressively, the critical micelle concentration of F68‐CDEC was 58‐fold smaller than that of F68. Besides, the drug loading content (LC = 20.25%) was higher than that of F68 (LC = 13.42%). In vitro release experiments showed that the reductant dithiothreitol triggered rapid disintegration of micelles with an accumulated drug amount of 55%, compared with an accumulated drug amount of 20% in phosphate‐buffered saline solution. These good abilities were further proved by cell uptake experiments. More importantly, almost no cytotoxicity was observed by 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide (MTT) colorimetric assay and immunofluorescence staining experiments. There are reasons to believe that the polymer F68‐CDEC can be used as a reduction‐sensitive drug delivery material. © 2020 Society of Industrial Chemistry" @default.
- W3048448153 created "2020-08-18" @default.
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- W3048448153 date "2020-09-07" @default.
- W3048448153 modified "2023-09-25" @default.
- W3048448153 title "Reduction‐sensitive carrier containing disulfide bond based on Pluronic F68 with cholesterol for drug delivery" @default.
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- W3048448153 doi "https://doi.org/10.1002/pi.6099" @default.
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