Matches in SemOpenAlex for { <https://semopenalex.org/work/W3048449951> ?p ?o ?g. }
- W3048449951 endingPage "1874" @default.
- W3048449951 startingPage "1874" @default.
- W3048449951 abstract "Protein kinase type C-ε (PKCε) plays important roles in the sensitization of primary afferent nociceptors, such as ion channel phosphorylation, that in turn promotes mechanical hyperalgesia and pain chronification. In these neurons, PKCε is modulated through the local release of mediators by the surrounding Schwann cells (SCs). The progesterone metabolite allopregnanolone (ALLO) is endogenously synthesized by SCs, whereas it has proven to be a crucial mediator of neuron-glia interaction in peripheral nerve fibers. Biomolecular and pharmacological studies on rat primary SCs and dorsal root ganglia (DRG) neuronal cultures were aimed at investigating the hypothesis that ALLO modulates neuronal PKCε, playing a role in peripheral nociception. We found that SCs tonically release ALLO, which, in turn, autocrinally upregulated the synthesis of the growth factor brain-derived neurotrophic factor (BDNF). Subsequently, glial BDNF paracrinally activates PKCε via trkB in DRG sensory neurons. Herein, we report a novel mechanism of SCs-neuron cross-talk in the peripheral nervous system, highlighting a key role of ALLO and BDNF in nociceptor sensitization. These findings emphasize promising targets for inhibiting the development and chronification of neuropathic pain." @default.
- W3048449951 created "2020-08-18" @default.
- W3048449951 creator A5002963265 @default.
- W3048449951 creator A5004780718 @default.
- W3048449951 creator A5005522310 @default.
- W3048449951 creator A5014663258 @default.
- W3048449951 creator A5016689981 @default.
- W3048449951 creator A5062077189 @default.
- W3048449951 creator A5067614773 @default.
- W3048449951 creator A5074424829 @default.
- W3048449951 creator A5080294002 @default.
- W3048449951 creator A5080844847 @default.
- W3048449951 creator A5090603265 @default.
- W3048449951 date "2020-08-11" @default.
- W3048449951 modified "2023-10-14" @default.
- W3048449951 title "Schwann Cell Autocrine and Paracrine Regulatory Mechanisms, Mediated by Allopregnanolone and BDNF, Modulate PKCε in Peripheral Sensory Neurons" @default.
- W3048449951 cites W1553278460 @default.
- W3048449951 cites W1568010017 @default.
- W3048449951 cites W1600167674 @default.
- W3048449951 cites W1625740378 @default.
- W3048449951 cites W1701778517 @default.
- W3048449951 cites W1960355435 @default.
- W3048449951 cites W1976334278 @default.
- W3048449951 cites W1978412006 @default.
- W3048449951 cites W1979075898 @default.
- W3048449951 cites W1984929819 @default.
- W3048449951 cites W2004637658 @default.
- W3048449951 cites W2007201434 @default.
- W3048449951 cites W2024014699 @default.
- W3048449951 cites W2024053578 @default.
- W3048449951 cites W2029394013 @default.
- W3048449951 cites W2029854919 @default.
- W3048449951 cites W2029863311 @default.
- W3048449951 cites W2030076800 @default.
- W3048449951 cites W2031736836 @default.
- W3048449951 cites W2033072655 @default.
- W3048449951 cites W2038457835 @default.
- W3048449951 cites W2038597322 @default.
- W3048449951 cites W2046175607 @default.
- W3048449951 cites W2051384422 @default.
- W3048449951 cites W2051675716 @default.
- W3048449951 cites W2053606705 @default.
- W3048449951 cites W2054414357 @default.
- W3048449951 cites W2070510853 @default.
- W3048449951 cites W2073197172 @default.
- W3048449951 cites W2078316783 @default.
- W3048449951 cites W2079103153 @default.
- W3048449951 cites W2084267341 @default.
- W3048449951 cites W2089478011 @default.
- W3048449951 cites W2089624670 @default.
- W3048449951 cites W2098609823 @default.
- W3048449951 cites W2102129421 @default.
- W3048449951 cites W2119295015 @default.
- W3048449951 cites W2119442062 @default.
- W3048449951 cites W2125816605 @default.
- W3048449951 cites W2143587378 @default.
- W3048449951 cites W2150617526 @default.
- W3048449951 cites W2151301539 @default.
- W3048449951 cites W2157946702 @default.
- W3048449951 cites W2161271273 @default.
- W3048449951 cites W2170576851 @default.
- W3048449951 cites W2318427513 @default.
- W3048449951 cites W2502592343 @default.
- W3048449951 cites W2531761203 @default.
- W3048449951 cites W2564777270 @default.
- W3048449951 cites W2570706142 @default.
- W3048449951 cites W2582843660 @default.
- W3048449951 cites W2738548892 @default.
- W3048449951 cites W2767378564 @default.
- W3048449951 cites W2806358974 @default.
- W3048449951 cites W2891826632 @default.
- W3048449951 cites W2895934695 @default.
- W3048449951 cites W2923812497 @default.
- W3048449951 cites W3018417148 @default.
- W3048449951 cites W3045702863 @default.
- W3048449951 doi "https://doi.org/10.3390/cells9081874" @default.
- W3048449951 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7465687" @default.
- W3048449951 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32796542" @default.
- W3048449951 hasPublicationYear "2020" @default.
- W3048449951 type Work @default.
- W3048449951 sameAs 3048449951 @default.
- W3048449951 citedByCount "12" @default.
- W3048449951 countsByYear W30484499512020 @default.
- W3048449951 countsByYear W30484499512021 @default.
- W3048449951 countsByYear W30484499512022 @default.
- W3048449951 countsByYear W30484499512023 @default.
- W3048449951 crossrefType "journal-article" @default.
- W3048449951 hasAuthorship W3048449951A5002963265 @default.
- W3048449951 hasAuthorship W3048449951A5004780718 @default.
- W3048449951 hasAuthorship W3048449951A5005522310 @default.
- W3048449951 hasAuthorship W3048449951A5014663258 @default.
- W3048449951 hasAuthorship W3048449951A5016689981 @default.
- W3048449951 hasAuthorship W3048449951A5062077189 @default.
- W3048449951 hasAuthorship W3048449951A5067614773 @default.
- W3048449951 hasAuthorship W3048449951A5074424829 @default.
- W3048449951 hasAuthorship W3048449951A5080294002 @default.
- W3048449951 hasAuthorship W3048449951A5080844847 @default.
- W3048449951 hasAuthorship W3048449951A5090603265 @default.