FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3048452956> ?p ?o ?g. }

• W3048452956 abstract "Severe pre-eclampsia can cause significant mortality and morbidity for both mother and child, particularly when it occurs remote from term, between 24 and 34 weeks' gestation. The only known cure for this disease is delivery. Some obstetricians advocate early delivery to ensure that the development of serious maternal complications, such as eclampsia (fits) and kidney failure are prevented. Others prefer a more expectant approach, delaying delivery in an attempt to reduce the mortality and morbidity for the child that is associated with being born too early.To evaluate the comparative benefits and risks of a policy of early delivery by induction of labour or by caesarean section, after sufficient time has elapsed to administer corticosteroids, and allow them to take effect; with a policy of delaying delivery (expectant care) for women with severe pre-eclampsia between 24 and 34 weeks' gestation.For this update, we searched Cochrane Pregnancy and Childbirth's Trials Register, ClinicalTrials.gov, the WHO International Clinical Trials Registry Platform (ICTRP) on 27 November 2017, and reference lists of retrieved studies.Randomised trials comparing the two intervention strategies for women with early onset, severe pre-eclampsia. Trials reported in an abstract were eligible for inclusion, as were cluster-trial designs. We excluded quasi-randomised trials.Three review authors independently assessed trials for inclusion and risk of bias, extracted data, and checked them for accuracy. We assessed the quality of the evidence for specified outcomes using the GRADE approach.We included six trials, with a total of 748 women in this review. All trials included women in whom there was no overriding indication for immediate delivery in the fetal or maternal interest. Half of the trials were at low risk of bias for methods of randomisation and allocation concealment; and four trials were at low risk for selective reporting. For most other domains, risk of bias was unclear. There were insufficient data for reliable conclusions about the comparative effects on most outcomes for the mother. Two studies reported on maternal deaths; neither study reported any deaths (two studies; 320 women; low-quality evidence). It was uncertain whether interventionist care reduced eclampsia (risk ratio (RR) 0.98, 95% confidence interval (CI) 0.06 to 15.58; two studies; 359 women) or pulmonary oedema (RR 0.45, 95% CI 0.07 to 3.00; two studies; 415 women), because the quality of the evidence for these outcomes was very low. Evidence from two studies suggested little or no clear difference between the interventionist and expectant care groups for HELLP (haemolysis, elevated liver enzymes, and low platelets) syndrome (RR 1.09, 95% CI 0.62 to 1.91; two studies; 359 women; low-quality evidence). No study reported on stroke. With the addition of data from two studies for this update, there was now evidence to suggest that interventionist care probably made little or no difference to the incidence of caesarean section (average RR 1.01, 95% CI 0.91 to 1.12; six studies; 745 women; Heterogeneity: Tau² = 0.01; I² = 63%).For the baby, there was insufficient evidence to draw reliable conclusions about the effects on perinatal deaths (RR 1.11, 95% CI 0.62 to 1.99; three studies; 343 women; low-quality evidence). Babies whose mothers had been allocated to the interventionist group had more intraventricular haemorrhage (RR 1.94, 95% CI 1.15 to 3.29; two studies; 537 women; moderate-quality evidence), more respiratory distress caused by hyaline membrane disease (RR 2.30, 95% CI 1.39 to 3.81; two studies; 133 women), required more ventilation (RR 1.50, 95% CI 1.11 to 2.02; two studies; 300 women), and were more likely to have a lower gestation at birth (mean difference (MD) -9.91 days, 95% CI -16.37 to -3.45 days; four studies; 425 women; Heterogeneity: Tau² = 31.74; I² = 76%). However, babies whose mothers had been allocated to the interventionist group were no more likely to be admitted to neonatal intensive care (average RR 1.19, 95% CI 0.89 to 1.60; three studies; 400 infants; Heterogeneity: Tau² = 0.05; I² = 84%). Babies born to mothers in the interventionist groups were more likely to have a longer stay in the neonatal intensive care unit (MD 7.38 days, 95% CI -0.45 to 15.20 days; three studies; 400 women; Heterogeneity: Tau² = 40.93, I² = 85%) and were less likely to be small-for-gestational age (RR 0.38, 95% CI 0.24 to 0.61; three studies; 400 women). There were no clear differences between the two strategies for any other outcomes.This review suggested that an expectant approach to the management of women with severe early onset pre-eclampsia may be associated with decreased morbidity for the baby. However, this evidence was based on data from only six trials. Further large, high-quality trials are needed to confirm or refute these findings, and establish if this approach is safe for the mother." @default.
• W3048452956 created "2020-08-18" @default.
• W3048452956 creator A5007168761 @default.
• W3048452956 creator A5016928699 @default.
• W3048452956 creator A5019032458 @default.
• W3048452956 creator A5021661696 @default.
• W3048452956 creator A5064605950 @default.
• W3048452956 creator A5067179548 @default.
• W3048452956 date "2018-10-05" @default.
• W3048452956 modified "2023-09-27" @default.
• W3048452956 title "Interventionist versus expectant care for severe pre-eclampsia between 24 and 34 weeks' gestation" @default.
• W3048452956 cites W1525772616 @default.
• W3048452956 cites W1595383938 @default.
• W3048452956 cites W1602847836 @default.
• W3048452956 cites W1693011515 @default.
• W3048452956 cites W1900449162 @default.
• W3048452956 cites W1902505065 @default.
• W3048452956 cites W1944880964 @default.
• W3048452956 cites W1963765713 @default.
• W3048452956 cites W1981398964 @default.
• W3048452956 cites W2008772471 @default.
• W3048452956 cites W2015794890 @default.
• W3048452956 cites W2046094671 @default.
• W3048452956 cites W2068787780 @default.
• W3048452956 cites W2082954910 @default.
• W3048452956 cites W2105827140 @default.
• W3048452956 cites W2128698850 @default.
• W3048452956 cites W2131408636 @default.
• W3048452956 cites W2134064617 @default.
• W3048452956 cites W2145085490 @default.
• W3048452956 cites W2145339846 @default.
• W3048452956 cites W2145530551 @default.
• W3048452956 cites W2145917688 @default.
• W3048452956 cites W2149439352 @default.
• W3048452956 cites W2153176170 @default.
• W3048452956 cites W2158512558 @default.
• W3048452956 cites W2160421746 @default.
• W3048452956 cites W2169101968 @default.
• W3048452956 cites W2405242623 @default.
• W3048452956 cites W2416738814 @default.
• W3048452956 cites W2912155331 @default.
• W3048452956 cites W3157738780 @default.
• W3048452956 cites W4242472190 @default.
• W3048452956 cites W4243572263 @default.
• W3048452956 cites W4249456774 @default.
• W3048452956 cites W4250266603 @default.
• W3048452956 doi "https://doi.org/10.1002/14651858.cd003106.pub3" @default.
• W3048452956 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30289565" @default.
• W3048452956 hasPublicationYear "2018" @default.
• W3048452956 type Work @default.
• W3048452956 sameAs 3048452956 @default.
• W3048452956 citedByCount "17" @default.
• W3048452956 countsByYear W30484529562015 @default.
• W3048452956 countsByYear W30484529562019 @default.
• W3048452956 countsByYear W30484529562020 @default.
• W3048452956 countsByYear W30484529562021 @default.
• W3048452956 countsByYear W30484529562022 @default.
• W3048452956 countsByYear W30484529562023 @default.
• W3048452956 crossrefType "journal-article" @default.
• W3048452956 hasAuthorship W3048452956A5007168761 @default.
• W3048452956 hasAuthorship W3048452956A5016928699 @default.
• W3048452956 hasAuthorship W3048452956A5019032458 @default.
• W3048452956 hasAuthorship W3048452956A5021661696 @default.
• W3048452956 hasAuthorship W3048452956A5064605950 @default.
• W3048452956 hasAuthorship W3048452956A5067179548 @default.
• W3048452956 hasBestOaLocation W30484529562 @default.
• W3048452956 hasConcept C126322002 @default.
• W3048452956 hasConcept C131872663 @default.
• W3048452956 hasConcept C141071460 @default.
• W3048452956 hasConcept C168563851 @default.
• W3048452956 hasConcept C187212893 @default.
• W3048452956 hasConcept C2776279924 @default.
• W3048452956 hasConcept C2779234561 @default.
• W3048452956 hasConcept C2779703513 @default.
• W3048452956 hasConcept C2781276381 @default.
• W3048452956 hasConcept C2908647359 @default.
• W3048452956 hasConcept C2908892503 @default.
• W3048452956 hasConcept C46973012 @default.
• W3048452956 hasConcept C535046627 @default.
• W3048452956 hasConcept C54355233 @default.
• W3048452956 hasConcept C71924100 @default.
• W3048452956 hasConcept C86803240 @default.
• W3048452956 hasConcept C99454951 @default.
• W3048452956 hasConceptScore W3048452956C126322002 @default.
• W3048452956 hasConceptScore W3048452956C131872663 @default.
• W3048452956 hasConceptScore W3048452956C141071460 @default.
• W3048452956 hasConceptScore W3048452956C168563851 @default.
• W3048452956 hasConceptScore W3048452956C187212893 @default.
• W3048452956 hasConceptScore W3048452956C2776279924 @default.
• W3048452956 hasConceptScore W3048452956C2779234561 @default.
• W3048452956 hasConceptScore W3048452956C2779703513 @default.
• W3048452956 hasConceptScore W3048452956C2781276381 @default.
• W3048452956 hasConceptScore W3048452956C2908647359 @default.
• W3048452956 hasConceptScore W3048452956C2908892503 @default.
• W3048452956 hasConceptScore W3048452956C46973012 @default.
• W3048452956 hasConceptScore W3048452956C535046627 @default.
• W3048452956 hasConceptScore W3048452956C54355233 @default.
• W3048452956 hasConceptScore W3048452956C71924100 @default.
• W3048452956 hasConceptScore W3048452956C86803240 @default.
• W3048452956 hasConceptScore W3048452956C99454951 @default.

• next