Matches in SemOpenAlex for { <https://semopenalex.org/work/W3048454922> ?p ?o ?g. }
- W3048454922 endingPage "102379" @default.
- W3048454922 startingPage "102379" @default.
- W3048454922 abstract "Abstract Recent modeling and experimental evidence suggests clearance of soluble metabolites from the brain can be driven by low frequency flow oscillations (LFOs) through the intramural periarterial drainage (IPAD) pathway. This study investigates the use of 4D flow MRI to derive LFOs from arterial and venous measures of blood flow. 3D radial 4D flow MRI data were acquired on a 3.0 T scanner and reconstructed using a low-rank constraint to produce time resolved measurements of blood flow. Physical phantom experiments were performed to validate the time resolved 4D flow against a standard 2D phase contrast (PC) approach. To evaluate the ability of 4D flow to distinguish physiologic flow changes from noise, healthy volunteers were scanned during a breath-hold (BH) maneuver and compared against 2D PC measures. Finally, flow measures were performed in intracranial arteries and veins of 112 participants including subjects diagnosed with Alzheimer’s disease (AD) clinical syndrome (n = 23), and healthy controls (n = 89) on whom apolipoprotein ɛ4 positivity (APOE4+) and parental history of AD dementia (FH+) was known. To assess LFOs, flow range, standard deviation, demeaned temporal flow changes, and power spectral density were quantified from the time series. Group differences were assessed using ANOVA followed by Tukey-Kramer method for pairwise comparison for adjusted means (P" @default.
- W3048454922 created "2020-08-18" @default.
- W3048454922 creator A5008939864 @default.
- W3048454922 creator A5025047782 @default.
- W3048454922 creator A5042955161 @default.
- W3048454922 creator A5043910775 @default.
- W3048454922 creator A5068324824 @default.
- W3048454922 creator A5077702147 @default.
- W3048454922 creator A5084184002 @default.
- W3048454922 creator A5084579251 @default.
- W3048454922 creator A5090940361 @default.
- W3048454922 date "2020-01-01" @default.
- W3048454922 modified "2023-09-24" @default.
- W3048454922 title "Intracranial vascular flow oscillations in Alzheimer’s disease from 4D flow MRI" @default.
- W3048454922 cites W1540061466 @default.
- W3048454922 cites W179558530 @default.
- W3048454922 cites W1829608562 @default.
- W3048454922 cites W1965274315 @default.
- W3048454922 cites W1975226706 @default.
- W3048454922 cites W1977604869 @default.
- W3048454922 cites W1978421595 @default.
- W3048454922 cites W1986387796 @default.
- W3048454922 cites W1997314707 @default.
- W3048454922 cites W2029995174 @default.
- W3048454922 cites W2059104398 @default.
- W3048454922 cites W2071853069 @default.
- W3048454922 cites W2072654712 @default.
- W3048454922 cites W2115017507 @default.
- W3048454922 cites W211905087 @default.
- W3048454922 cites W2120070267 @default.
- W3048454922 cites W2128307173 @default.
- W3048454922 cites W2129497119 @default.
- W3048454922 cites W2138209376 @default.
- W3048454922 cites W2156220037 @default.
- W3048454922 cites W2158742097 @default.
- W3048454922 cites W2159122269 @default.
- W3048454922 cites W2163710334 @default.
- W3048454922 cites W2167183660 @default.
- W3048454922 cites W2170116902 @default.
- W3048454922 cites W2170432972 @default.
- W3048454922 cites W2427396022 @default.
- W3048454922 cites W2427948242 @default.
- W3048454922 cites W2460109857 @default.
- W3048454922 cites W2492605684 @default.
- W3048454922 cites W2498934596 @default.
- W3048454922 cites W2543794315 @default.
- W3048454922 cites W2580383152 @default.
- W3048454922 cites W2582524520 @default.
- W3048454922 cites W2748695148 @default.
- W3048454922 cites W2749371381 @default.
- W3048454922 cites W2773427194 @default.
- W3048454922 cites W2784286959 @default.
- W3048454922 cites W2784671095 @default.
- W3048454922 cites W2786608785 @default.
- W3048454922 cites W2791117510 @default.
- W3048454922 cites W2798054687 @default.
- W3048454922 cites W2889965831 @default.
- W3048454922 cites W2901166225 @default.
- W3048454922 cites W2910508414 @default.
- W3048454922 cites W2912533302 @default.
- W3048454922 cites W2913113106 @default.
- W3048454922 cites W2936365596 @default.
- W3048454922 cites W2950459061 @default.
- W3048454922 cites W2951738275 @default.
- W3048454922 cites W2956769288 @default.
- W3048454922 cites W2962527742 @default.
- W3048454922 cites W2993316870 @default.
- W3048454922 cites W2996003253 @default.
- W3048454922 cites W3004827233 @default.
- W3048454922 cites W3005010059 @default.
- W3048454922 cites W3007856943 @default.
- W3048454922 cites W4249760698 @default.
- W3048454922 doi "https://doi.org/10.1016/j.nicl.2020.102379" @default.
- W3048454922 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7476069" @default.
- W3048454922 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32871386" @default.
- W3048454922 hasPublicationYear "2020" @default.
- W3048454922 type Work @default.
- W3048454922 sameAs 3048454922 @default.
- W3048454922 citedByCount "11" @default.
- W3048454922 countsByYear W30484549222021 @default.
- W3048454922 countsByYear W30484549222022 @default.
- W3048454922 countsByYear W30484549222023 @default.
- W3048454922 crossrefType "journal-article" @default.
- W3048454922 hasAuthorship W3048454922A5008939864 @default.
- W3048454922 hasAuthorship W3048454922A5025047782 @default.
- W3048454922 hasAuthorship W3048454922A5042955161 @default.
- W3048454922 hasAuthorship W3048454922A5043910775 @default.
- W3048454922 hasAuthorship W3048454922A5068324824 @default.
- W3048454922 hasAuthorship W3048454922A5077702147 @default.
- W3048454922 hasAuthorship W3048454922A5084184002 @default.
- W3048454922 hasAuthorship W3048454922A5084579251 @default.
- W3048454922 hasAuthorship W3048454922A5090940361 @default.
- W3048454922 hasBestOaLocation W30484549221 @default.
- W3048454922 hasConcept C121332964 @default.
- W3048454922 hasConcept C157767197 @default.
- W3048454922 hasConcept C164705383 @default.
- W3048454922 hasConcept C2910811945 @default.
- W3048454922 hasConcept C38349280 @default.