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- W3048455895 endingPage "382" @default.
- W3048455895 startingPage "371" @default.
- W3048455895 abstract "The Ca2+release-activated Ca2+ (CRAC) channel, composed of Orai and STIM proteins, represents one of the main routes of Ca2+ entry in most non-excitable cells. There is accumulating evidence to suggest that CRAC channel can influence various processes associated with tumorigenesis. Overexpression of CRAC channel proteins has been observed in several types of cancer tissues and cells, indicating that blocking CRAC channel activated Ca2+ influx can have therapeutic benefits for cancer patients.In this review, we have primarily focused on the molecular composition and activation mechanism of CRAC channel as well as the myriad roles this Ca2+ channel play in various cancers. We further describe relevant information about several efforts aimed at developing CRAC channel blockers and their likely implications for cancer therapy. We have extensively utilized the available literature on PubMed to this end.The possibility of targeting CRAC channel mediated Ca2+ entry in cancer cells has generated considerable interest in recent years. Use of CRAC channel blockers in cancer preclinical studies and clinical trials has been relatively limited as compared to other diseases. The future lies in developing and testing more potent and selective drugs that target cancer cell specific CRAC channel proteins, hence opening better avenues for cancer therapeutic development." @default.
- W3048455895 created "2020-08-18" @default.
- W3048455895 creator A5026049304 @default.
- W3048455895 creator A5037090507 @default.
- W3048455895 creator A5068114478 @default.
- W3048455895 creator A5076775886 @default.
- W3048455895 creator A5091188735 @default.
- W3048455895 date "2020-08-11" @default.
- W3048455895 modified "2023-10-18" @default.
- W3048455895 title "Roles of CRAC channel in cancer: implications for therapeutic development" @default.
- W3048455895 cites W1485079157 @default.
- W3048455895 cites W1485297825 @default.
- W3048455895 cites W1489640151 @default.
- W3048455895 cites W1495215957 @default.
- W3048455895 cites W1514419162 @default.
- W3048455895 cites W1554199623 @default.
- W3048455895 cites W1575476642 @default.
- W3048455895 cites W1576575094 @default.
- W3048455895 cites W1640752252 @default.
- W3048455895 cites W1858595724 @default.
- W3048455895 cites W1905646030 @default.
- W3048455895 cites W1963703355 @default.
- W3048455895 cites W1978593035 @default.
- W3048455895 cites W1980633311 @default.
- W3048455895 cites W1982218418 @default.
- W3048455895 cites W1982528213 @default.
- W3048455895 cites W1982620047 @default.
- W3048455895 cites W1985267758 @default.
- W3048455895 cites W1985729132 @default.
- W3048455895 cites W1985785210 @default.
- W3048455895 cites W1985924867 @default.
- W3048455895 cites W1986531910 @default.
- W3048455895 cites W1992157292 @default.
- W3048455895 cites W1997930612 @default.
- W3048455895 cites W2001501677 @default.
- W3048455895 cites W2004234324 @default.
- W3048455895 cites W2005700813 @default.
- W3048455895 cites W2007081924 @default.
- W3048455895 cites W2015331270 @default.
- W3048455895 cites W2016348702 @default.
- W3048455895 cites W2023518937 @default.
- W3048455895 cites W2028649950 @default.
- W3048455895 cites W2028958004 @default.
- W3048455895 cites W2031966403 @default.
- W3048455895 cites W2036145275 @default.
- W3048455895 cites W2038951793 @default.
- W3048455895 cites W2041383551 @default.
- W3048455895 cites W2041748354 @default.
- W3048455895 cites W2043519102 @default.
- W3048455895 cites W2044563193 @default.
- W3048455895 cites W2050443418 @default.
- W3048455895 cites W2050852558 @default.
- W3048455895 cites W2052173175 @default.
- W3048455895 cites W2055345629 @default.
- W3048455895 cites W2055479746 @default.
- W3048455895 cites W2056985832 @default.
- W3048455895 cites W2057315057 @default.
- W3048455895 cites W2058622754 @default.
- W3048455895 cites W205915804 @default.
- W3048455895 cites W2061725286 @default.
- W3048455895 cites W2064719918 @default.
- W3048455895 cites W2066906512 @default.
- W3048455895 cites W2070193172 @default.
- W3048455895 cites W2070832223 @default.
- W3048455895 cites W2073302858 @default.
- W3048455895 cites W2077807460 @default.
- W3048455895 cites W2079071687 @default.
- W3048455895 cites W2079664650 @default.
- W3048455895 cites W2080482829 @default.
- W3048455895 cites W2081747826 @default.
- W3048455895 cites W2084077773 @default.
- W3048455895 cites W2094666006 @default.
- W3048455895 cites W2097265484 @default.
- W3048455895 cites W2100007794 @default.
- W3048455895 cites W2100578216 @default.
- W3048455895 cites W2101586949 @default.
- W3048455895 cites W2102097918 @default.
- W3048455895 cites W2102525336 @default.
- W3048455895 cites W2109745844 @default.
- W3048455895 cites W2112666227 @default.
- W3048455895 cites W2114366598 @default.
- W3048455895 cites W2117958014 @default.
- W3048455895 cites W2121492490 @default.
- W3048455895 cites W2132781656 @default.
- W3048455895 cites W2133603157 @default.
- W3048455895 cites W2134062610 @default.
- W3048455895 cites W2143654194 @default.
- W3048455895 cites W2144122654 @default.
- W3048455895 cites W2153514892 @default.
- W3048455895 cites W2163789582 @default.
- W3048455895 cites W2165074913 @default.
- W3048455895 cites W2167136073 @default.
- W3048455895 cites W2345685532 @default.
- W3048455895 cites W2412698309 @default.
- W3048455895 cites W2415989421 @default.
- W3048455895 cites W2506844371 @default.
- W3048455895 cites W2549594996 @default.
- W3048455895 cites W2551327336 @default.