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- W3048456013 endingPage "101055" @default.
- W3048456013 startingPage "101055" @default.
- W3048456013 abstract "Over the past decade, the study of metabolic abnormalities in cancer cells has risen dramatically. Cancer cells can thrive in challenging environments, be it the hypoxic and nutrient-deplete tumor microenvironment or a distant tissue following metastasis. The ways in which cancer cells utilize lipids are often influenced by the complex interactions within the tumor microenvironment and adjacent stroma. Adipocytes can be activated by cancer cells to lipolyze their triglyceride stores, delivering secreted fatty acids to cancer cells for uptake through numerous fatty acid transporters. Cancer-associated fibroblasts are also implicated in lipid secretion for cancer cell catabolism and lipid signaling leading to activation of mitogenic and migratory pathways. As these cancer-stromal interactions are exacerbated during tumor progression, fatty acids secreted into the microenvironment can impact infiltrating immune cell function and phenotype. Lipid metabolic abnormalities such as increased fatty acid oxidation and de novo lipid synthesis can provide survival advantages for the tumor to resist chemotherapeutic and radiation treatments and alleviate cellular stresses involved in the metastatic cascade. In this review, we highlight recent literature that demonstrates how lipids can shape each part of the cancer lifecycle and show that there is significant potential for therapeutic intervention surrounding lipid metabolic and signaling pathways." @default.
- W3048456013 created "2020-08-18" @default.
- W3048456013 creator A5005535100 @default.
- W3048456013 creator A5006499998 @default.
- W3048456013 creator A5019006080 @default.
- W3048456013 date "2020-11-01" @default.
- W3048456013 modified "2023-10-17" @default.
- W3048456013 title "Lipids in the tumor microenvironment: From cancer progression to treatment" @default.
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