FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3048458579> ?p ?o ?g. }

• W3048458579 endingPage "101854" @default.
• W3048458579 startingPage "101854" @default.
• W3048458579 abstract "Methamphetamine (METH) is a high addictive psychostimulant drug which triggers brain atrophy via neuronal degeneration. Striatum is the main part of the brain that is regarded as a key target for drug-induced damages. MiRNAs as small regulatory molecules at the post-transcriptional level play a major role in biological pathways. In this study, initially we performed behavioral assessment in METH-treated rats. Then, we examined striatal volume and dendritic length, and also the levels of tyrosine hydroxylase (TH), caspase-3 and glial fibrillary acidic protein (GFAP) were immunohistochemically assessed. Moreover, we investigated miRNA expression profiling using high-throughput small RNA-seq technology. Based on our data, METH provoked declined motor coordination, decreases in striatal volume and dendritic length along with over-activation of astrogliosis. In addition, METH treatment down-regulated TH level while it induced up-regulation of caspase-3 in the striatal region. Furthermore, according to miR-seq analysis, we found 167 deregulated miRNAs in the striatum upon METH treatment, that among them rno-let-7b-5p, rno-miR-485-5p, rno-miR-326-3p, rno-miR-34a-5p, rno-miR-3068-5p showed high miRNA-target gene interaction. Pathway analysis revealed that miRNAs and their target genes may be involved in cell apoptosis, growth, differentiation as well as synaptic plasticity associated pathways. Altogether, we can conclude that METH noticeably elicited neuro-degeneration in the dorsal striatum." @default.
• W3048458579 created "2020-08-18" @default.
• W3048458579 creator A5014040588 @default.
• W3048458579 creator A5030407679 @default.
• W3048458579 creator A5035946275 @default.
• W3048458579 creator A5042304352 @default.
• W3048458579 creator A5046229497 @default.
• W3048458579 creator A5054909624 @default.
• W3048458579 creator A5065686837 @default.
• W3048458579 creator A5075445175 @default.
• W3048458579 creator A5089619084 @default.
• W3048458579 date "2020-11-01" @default.
• W3048458579 modified "2023-09-24" @default.
• W3048458579 title "From dysregulated microRNAs to structural alterations in the striatal region of METH-injected rats" @default.
• W3048458579 cites W1789340278 @default.
• W3048458579 cites W1968048495 @default.
• W3048458579 cites W1968383275 @default.
• W3048458579 cites W1984214021 @default.
• W3048458579 cites W2005241715 @default.
• W3048458579 cites W2006063093 @default.
• W3048458579 cites W2026302172 @default.
• W3048458579 cites W2038071695 @default.
• W3048458579 cites W2048630757 @default.
• W3048458579 cites W2053989396 @default.
• W3048458579 cites W2057436796 @default.
• W3048458579 cites W2059406298 @default.
• W3048458579 cites W2065980876 @default.
• W3048458579 cites W2068311250 @default.
• W3048458579 cites W2069303592 @default.
• W3048458579 cites W2077812249 @default.
• W3048458579 cites W2080253613 @default.
• W3048458579 cites W2090183355 @default.
• W3048458579 cites W2091073665 @default.
• W3048458579 cites W2096980898 @default.
• W3048458579 cites W2123907069 @default.
• W3048458579 cites W2124985265 @default.
• W3048458579 cites W2129017955 @default.
• W3048458579 cites W2129511674 @default.
• W3048458579 cites W2132373383 @default.
• W3048458579 cites W2133807249 @default.
• W3048458579 cites W2138207763 @default.
• W3048458579 cites W2147326367 @default.
• W3048458579 cites W2154345916 @default.
• W3048458579 cites W2161106528 @default.
• W3048458579 cites W2181707684 @default.
• W3048458579 cites W2282831137 @default.
• W3048458579 cites W2341117915 @default.
• W3048458579 cites W2725830205 @default.
• W3048458579 cites W2742667596 @default.
• W3048458579 cites W2774077521 @default.
• W3048458579 cites W2925281302 @default.
• W3048458579 cites W2971523469 @default.
• W3048458579 cites W2988080152 @default.
• W3048458579 cites W904184522 @default.
• W3048458579 doi "https://doi.org/10.1016/j.jchemneu.2020.101854" @default.
• W3048458579 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32795519" @default.
• W3048458579 hasPublicationYear "2020" @default.
• W3048458579 type Work @default.
• W3048458579 sameAs 3048458579 @default.
• W3048458579 citedByCount "11" @default.
• W3048458579 countsByYear W30484585792021 @default.
• W3048458579 countsByYear W30484585792022 @default.
• W3048458579 countsByYear W30484585792023 @default.
• W3048458579 crossrefType "journal-article" @default.
• W3048458579 hasAuthorship W3048458579A5014040588 @default.
• W3048458579 hasAuthorship W3048458579A5030407679 @default.
• W3048458579 hasAuthorship W3048458579A5035946275 @default.
• W3048458579 hasAuthorship W3048458579A5042304352 @default.
• W3048458579 hasAuthorship W3048458579A5046229497 @default.
• W3048458579 hasAuthorship W3048458579A5054909624 @default.
• W3048458579 hasAuthorship W3048458579A5065686837 @default.
• W3048458579 hasAuthorship W3048458579A5075445175 @default.
• W3048458579 hasAuthorship W3048458579A5089619084 @default.
• W3048458579 hasConcept C104317684 @default.
• W3048458579 hasConcept C145059251 @default.
• W3048458579 hasConcept C159167319 @default.
• W3048458579 hasConcept C166940927 @default.
• W3048458579 hasConcept C169760540 @default.
• W3048458579 hasConcept C178790620 @default.
• W3048458579 hasConcept C185592680 @default.
• W3048458579 hasConcept C2779965356 @default.
• W3048458579 hasConcept C2779989194 @default.
• W3048458579 hasConcept C2780062018 @default.
• W3048458579 hasConcept C2780114369 @default.
• W3048458579 hasConcept C2780376393 @default.
• W3048458579 hasConcept C513476851 @default.
• W3048458579 hasConcept C521977710 @default.
• W3048458579 hasConcept C529278444 @default.
• W3048458579 hasConcept C54355233 @default.
• W3048458579 hasConcept C86803240 @default.
• W3048458579 hasConcept C98274493 @default.
• W3048458579 hasConceptScore W3048458579C104317684 @default.
• W3048458579 hasConceptScore W3048458579C145059251 @default.
• W3048458579 hasConceptScore W3048458579C159167319 @default.
• W3048458579 hasConceptScore W3048458579C166940927 @default.
• W3048458579 hasConceptScore W3048458579C169760540 @default.
• W3048458579 hasConceptScore W3048458579C178790620 @default.
• W3048458579 hasConceptScore W3048458579C185592680 @default.

• next