FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3048462555> ?p ?o ?g. }

• W3048462555 abstract "Background: Acute myeloid leukemia is a genetically, biologically and clinically heterogeneous hematopoietic malignancy that is highly dependent on the bone marrow microenvironment. Infiltrated immune cells and stromal cells are an important part of the bone marrow microenvironment and significantly affect the progression of acute myeloid leukemia. Recently, the competing endogenous RNA hypothesis has gained great interests in the study of molecular and biological mechanisms of tumor occurrence and progression. However, research on how competing endogenous RNA relates to leukemia tumor microenvironment remains uninvestigated. Methods: In this study, mRNA, miRNA and lncRNA data and clinical information of the acute myeloid leukemia cohort were obtained from The Cancer Genome Atlas database, and the immune and stromal scores were calculated using the ESTIMATE algorithm. Results: We found that immune scores were significantly correlated with cytogenetic risk and overall survival, and also identified microenvironment-related mRNAs, miRNAs, and lncRNAs based on the immune and stromal scores. Differentially expressed mRNAs and lncRNAs were applied to weighted correlation network analysis to identify the modules most relevant to the immune microenvironment of acute myeloid leukemia. Using miRNA database to predict miRNA-targeted genes, we established the immune-related competing endogenous RNA network consisting of 33 lncRNAs, 21 miRNAs and 135 mRNAs. Prognostic analysis was performed on the genes in the immune-related competing endogenous RNA network to screen out 15 lncRNAs, 2 miRNAs and 31 mRNAs with prognostic values. Conclusions: In summary, we identified a novel immune-related mRNA-miRNA-lncRNA competing endogenous RNA network associated with the prognosis of acute myeloid leukemia, which may contribute to better understanding of the development and progression of acute myeloid leukemia and to serve as novel therapeutic targets." @default.
• W3048462555 created "2020-08-18" @default.
• W3048462555 creator A5007803202 @default.
• W3048462555 creator A5010368680 @default.
• W3048462555 creator A5022559283 @default.
• W3048462555 creator A5023546935 @default.
• W3048462555 creator A5033746402 @default.
• W3048462555 creator A5060394961 @default.
• W3048462555 creator A5082557734 @default.
• W3048462555 creator A5088192232 @default.
• W3048462555 date "2020-08-11" @default.
• W3048462555 modified "2023-10-16" @default.
• W3048462555 title "A Novel Immune-Related Competing Endogenous RNA Network Predicts Prognosis of Acute Myeloid Leukemia" @default.
• W3048462555 cites W1966327575 @default.
• W3048462555 cites W1980952112 @default.
• W3048462555 cites W2011477466 @default.
• W3048462555 cites W2035614371 @default.
• W3048462555 cites W2041848167 @default.
• W3048462555 cites W2042728323 @default.
• W3048462555 cites W2043046186 @default.
• W3048462555 cites W2046387002 @default.
• W3048462555 cites W2088962068 @default.
• W3048462555 cites W2098796621 @default.
• W3048462555 cites W2106976893 @default.
• W3048462555 cites W2116432220 @default.
• W3048462555 cites W2130430382 @default.
• W3048462555 cites W2139048816 @default.
• W3048462555 cites W2142428512 @default.
• W3048462555 cites W2143835472 @default.
• W3048462555 cites W2146512944 @default.
• W3048462555 cites W2150690000 @default.
• W3048462555 cites W2152874777 @default.
• W3048462555 cites W2159482845 @default.
• W3048462555 cites W2160068229 @default.
• W3048462555 cites W2264829991 @default.
• W3048462555 cites W2384094940 @default.
• W3048462555 cites W2510001336 @default.
• W3048462555 cites W2546297708 @default.
• W3048462555 cites W2553702171 @default.
• W3048462555 cites W2591153485 @default.
• W3048462555 cites W2597359422 @default.
• W3048462555 cites W2738658820 @default.
• W3048462555 cites W2801475086 @default.
• W3048462555 cites W2893588482 @default.
• W3048462555 cites W2894059080 @default.
• W3048462555 cites W2904118627 @default.
• W3048462555 cites W2921500565 @default.
• W3048462555 cites W2947193074 @default.
• W3048462555 cites W2958396592 @default.
• W3048462555 cites W2980412861 @default.
• W3048462555 cites W2982084340 @default.
• W3048462555 cites W2988025606 @default.
• W3048462555 cites W2991034912 @default.
• W3048462555 cites W2998792962 @default.
• W3048462555 cites W3004436904 @default.
• W3048462555 cites W4294216483 @default.
• W3048462555 doi "https://doi.org/10.3389/fonc.2020.01579" @default.
• W3048462555 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7432272" @default.
• W3048462555 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32850463" @default.
• W3048462555 hasPublicationYear "2020" @default.
• W3048462555 type Work @default.
• W3048462555 sameAs 3048462555 @default.
• W3048462555 citedByCount "8" @default.
• W3048462555 countsByYear W30484625552021 @default.
• W3048462555 countsByYear W30484625552022 @default.
• W3048462555 countsByYear W30484625552023 @default.
• W3048462555 crossrefType "journal-article" @default.
• W3048462555 hasAuthorship W3048462555A5007803202 @default.
• W3048462555 hasAuthorship W3048462555A5010368680 @default.
• W3048462555 hasAuthorship W3048462555A5022559283 @default.
• W3048462555 hasAuthorship W3048462555A5023546935 @default.
• W3048462555 hasAuthorship W3048462555A5033746402 @default.
• W3048462555 hasAuthorship W3048462555A5060394961 @default.
• W3048462555 hasAuthorship W3048462555A5082557734 @default.
• W3048462555 hasAuthorship W3048462555A5088192232 @default.
• W3048462555 hasBestOaLocation W30484625551 @default.
• W3048462555 hasConcept C104317684 @default.
• W3048462555 hasConcept C145059251 @default.
• W3048462555 hasConcept C16930146 @default.
• W3048462555 hasConcept C203014093 @default.
• W3048462555 hasConcept C2776107976 @default.
• W3048462555 hasConcept C2778461978 @default.
• W3048462555 hasConcept C2778729363 @default.
• W3048462555 hasConcept C2779282312 @default.
• W3048462555 hasConcept C2780007613 @default.
• W3048462555 hasConcept C502942594 @default.
• W3048462555 hasConcept C54355233 @default.
• W3048462555 hasConcept C60365752 @default.
• W3048462555 hasConcept C62203573 @default.
• W3048462555 hasConcept C67705224 @default.
• W3048462555 hasConcept C86803240 @default.
• W3048462555 hasConcept C8891405 @default.
• W3048462555 hasConceptScore W3048462555C104317684 @default.
• W3048462555 hasConceptScore W3048462555C145059251 @default.
• W3048462555 hasConceptScore W3048462555C16930146 @default.
• W3048462555 hasConceptScore W3048462555C203014093 @default.
• W3048462555 hasConceptScore W3048462555C2776107976 @default.
• W3048462555 hasConceptScore W3048462555C2778461978 @default.
• W3048462555 hasConceptScore W3048462555C2778729363 @default.
• W3048462555 hasConceptScore W3048462555C2779282312 @default.

• next