Matches in SemOpenAlex for { <https://semopenalex.org/work/W3048467449> ?p ?o ?g. }
- W3048467449 endingPage "315" @default.
- W3048467449 startingPage "301" @default.
- W3048467449 abstract "Hereditary variant transthyretin amyloidosis (ATTRv) is a rare genetic defect that affects about 5000–10,000 people worldwide, causing amyloidosis secondary to misfolding of mutant transthyretin (TTR) protein fibrils. TTR mutations can cause protein deposits in many extracellular regions of organs, but those deposits in cardiac and axonal cells are the primary cause of this clinical syndrome. Treatment options are limited, but new drugs are being developed. Patisiran, a novel drug, is a liposomal siRNA against TTR that specifically targets this protein, reducing the accumulation of TTR in tissues, with subsequent improvement in both neuropathy and cardiac function. Patisiran is likely to serve as a prototype for the development of further intelligent drug solutions for use in targeted therapy. In this review we summarize the evidence currently available on the treatment of polyneuropathy in people with ATTRv with patisiran. We review the evidence on its efficacy, safety, and indications of use, citing novel and seminal papers on these subjects." @default.
- W3048467449 created "2020-08-18" @default.
- W3048467449 creator A5014876140 @default.
- W3048467449 creator A5017606993 @default.
- W3048467449 creator A5018558604 @default.
- W3048467449 creator A5020048693 @default.
- W3048467449 creator A5043618109 @default.
- W3048467449 creator A5048334761 @default.
- W3048467449 creator A5050222489 @default.
- W3048467449 creator A5069497527 @default.
- W3048467449 creator A5078251206 @default.
- W3048467449 creator A5078485164 @default.
- W3048467449 date "2020-08-12" @default.
- W3048467449 modified "2023-10-14" @default.
- W3048467449 title "A Review of Patisiran (ONPATTRO®) for the Treatment of Polyneuropathy in People with Hereditary Transthyretin Amyloidosis" @default.
- W3048467449 cites W1808439685 @default.
- W3048467449 cites W2074977475 @default.
- W3048467449 cites W2080718344 @default.
- W3048467449 cites W2118369819 @default.
- W3048467449 cites W2140957589 @default.
- W3048467449 cites W2188931003 @default.
- W3048467449 cites W2212415077 @default.
- W3048467449 cites W2344137639 @default.
- W3048467449 cites W2405319848 @default.
- W3048467449 cites W2733669935 @default.
- W3048467449 cites W2754443480 @default.
- W3048467449 cites W2774176529 @default.
- W3048467449 cites W2774345751 @default.
- W3048467449 cites W2810909862 @default.
- W3048467449 cites W2889449782 @default.
- W3048467449 cites W2896456807 @default.
- W3048467449 cites W2903552105 @default.
- W3048467449 cites W2909972664 @default.
- W3048467449 cites W2912435333 @default.
- W3048467449 cites W2920438880 @default.
- W3048467449 cites W2921111398 @default.
- W3048467449 cites W2921617821 @default.
- W3048467449 cites W2935168662 @default.
- W3048467449 cites W2941514458 @default.
- W3048467449 cites W2942046145 @default.
- W3048467449 cites W2943784202 @default.
- W3048467449 cites W2943837292 @default.
- W3048467449 cites W2945253146 @default.
- W3048467449 cites W2945507495 @default.
- W3048467449 cites W2952789707 @default.
- W3048467449 cites W2955506073 @default.
- W3048467449 cites W2966119045 @default.
- W3048467449 doi "https://doi.org/10.1007/s40120-020-00208-1" @default.
- W3048467449 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7606409" @default.
- W3048467449 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32785879" @default.
- W3048467449 hasPublicationYear "2020" @default.
- W3048467449 type Work @default.
- W3048467449 sameAs 3048467449 @default.
- W3048467449 citedByCount "71" @default.
- W3048467449 countsByYear W30484674492020 @default.
- W3048467449 countsByYear W30484674492021 @default.
- W3048467449 countsByYear W30484674492022 @default.
- W3048467449 countsByYear W30484674492023 @default.
- W3048467449 crossrefType "journal-article" @default.
- W3048467449 hasAuthorship W3048467449A5014876140 @default.
- W3048467449 hasAuthorship W3048467449A5017606993 @default.
- W3048467449 hasAuthorship W3048467449A5018558604 @default.
- W3048467449 hasAuthorship W3048467449A5020048693 @default.
- W3048467449 hasAuthorship W3048467449A5043618109 @default.
- W3048467449 hasAuthorship W3048467449A5048334761 @default.
- W3048467449 hasAuthorship W3048467449A5050222489 @default.
- W3048467449 hasAuthorship W3048467449A5069497527 @default.
- W3048467449 hasAuthorship W3048467449A5078251206 @default.
- W3048467449 hasAuthorship W3048467449A5078485164 @default.
- W3048467449 hasBestOaLocation W30484674491 @default.
- W3048467449 hasConcept C121157162 @default.
- W3048467449 hasConcept C142724271 @default.
- W3048467449 hasConcept C169760540 @default.
- W3048467449 hasConcept C2775892965 @default.
- W3048467449 hasConcept C2777607188 @default.
- W3048467449 hasConcept C2777633098 @default.
- W3048467449 hasConcept C2777767895 @default.
- W3048467449 hasConcept C2779134260 @default.
- W3048467449 hasConcept C2779951007 @default.
- W3048467449 hasConcept C2780035454 @default.
- W3048467449 hasConcept C2910844529 @default.
- W3048467449 hasConcept C2994168385 @default.
- W3048467449 hasConcept C3019447875 @default.
- W3048467449 hasConcept C60644358 @default.
- W3048467449 hasConcept C71924100 @default.
- W3048467449 hasConcept C86803240 @default.
- W3048467449 hasConcept C98274493 @default.
- W3048467449 hasConceptScore W3048467449C121157162 @default.
- W3048467449 hasConceptScore W3048467449C142724271 @default.
- W3048467449 hasConceptScore W3048467449C169760540 @default.
- W3048467449 hasConceptScore W3048467449C2775892965 @default.
- W3048467449 hasConceptScore W3048467449C2777607188 @default.
- W3048467449 hasConceptScore W3048467449C2777633098 @default.
- W3048467449 hasConceptScore W3048467449C2777767895 @default.
- W3048467449 hasConceptScore W3048467449C2779134260 @default.
- W3048467449 hasConceptScore W3048467449C2779951007 @default.
- W3048467449 hasConceptScore W3048467449C2780035454 @default.
- W3048467449 hasConceptScore W3048467449C2910844529 @default.