Matches in SemOpenAlex for { <https://semopenalex.org/work/W3048471512> ?p ?o ?g. }
- W3048471512 endingPage "683" @default.
- W3048471512 startingPage "675" @default.
- W3048471512 abstract "Only few studies have shown the efficacy and safety of glucose-control strategies using the quadruple drug combination. Therefore, the aim of the present study was to investigate the usefulness of the quadruple combination therapy with oral hypoglycemic agents (OHAs) in patients with uncontrolled type 2 diabetes mellitus (T2DM).From March 2014 to December 2018, data of patients with T2DM, who were treated with quadruple hypoglycemic medications for over 12 months in 11 hospitals in South Korea, were reviewed retrospectively. We compared glycosylated hemoglobin (HbA1c) levels before and 12 months after quadruple treatment with OHAs. The safety, maintenance rate, and therapeutic patterns after failure of the quadruple therapy were also evaluated.In total, 357 patients were enrolled for quadruple OHA therapy, and the baseline HbA1c level was 9.0%±1.3% (74.9±14.1 mmol/mol). After 12 months, 270 patients (75.6%) adhered to the quadruple therapy and HbA1c was significantly reduced from 8.9%±1.2% to 7.8%±1.3% (mean change, -1.1%±1.2%; P<0.001). The number of patients with HbA1c <7% increased significantly from 5 to 68 (P<0.005). In addition, lipid profiles and liver enzyme levels were also improved whereas no changes in body weight. There was no significant safety issue in patients treated with quadruple OHA therapy.This study shows the therapeutic efficacy of the quadruple OHA regimen T2DM and demonstrates that it can be an option for the management of T2DM patients who cannot use insulin or reject injectable therapy." @default.
- W3048471512 created "2020-08-18" @default.
- W3048471512 creator A5000043225 @default.
- W3048471512 creator A5004011057 @default.
- W3048471512 creator A5005659473 @default.
- W3048471512 creator A5006157968 @default.
- W3048471512 creator A5006379529 @default.
- W3048471512 creator A5015416322 @default.
- W3048471512 creator A5016285288 @default.
- W3048471512 creator A5018749748 @default.
- W3048471512 creator A5021811682 @default.
- W3048471512 creator A5025932754 @default.
- W3048471512 creator A5034642565 @default.
- W3048471512 creator A5034730812 @default.
- W3048471512 creator A5035970733 @default.
- W3048471512 creator A5038639550 @default.
- W3048471512 creator A5041198204 @default.
- W3048471512 creator A5042388176 @default.
- W3048471512 creator A5046218780 @default.
- W3048471512 creator A5055614488 @default.
- W3048471512 creator A5063076347 @default.
- W3048471512 creator A5067267885 @default.
- W3048471512 creator A5067756034 @default.
- W3048471512 creator A5069588636 @default.
- W3048471512 creator A5071399014 @default.
- W3048471512 creator A5079755488 @default.
- W3048471512 creator A5079824142 @default.
- W3048471512 creator A5080197428 @default.
- W3048471512 creator A5080963529 @default.
- W3048471512 creator A5082863611 @default.
- W3048471512 creator A5088812559 @default.
- W3048471512 creator A5089182235 @default.
- W3048471512 creator A5090905205 @default.
- W3048471512 date "2021-09-30" @default.
- W3048471512 modified "2023-10-16" @default.
- W3048471512 title "Efficacy and Safety of Treatment with Quadruple Oral Hypoglycemic Agents in Uncontrolled Type 2 Diabetes Mellitus: A Multi-Center, Retrospective, Observational Study" @default.
- W3048471512 cites W1981706606 @default.
- W3048471512 cites W1985246022 @default.
- W3048471512 cites W2033255112 @default.
- W3048471512 cites W2109728760 @default.
- W3048471512 cites W2114117378 @default.
- W3048471512 cites W2118542451 @default.
- W3048471512 cites W2162449758 @default.
- W3048471512 cites W2191887473 @default.
- W3048471512 cites W2257006771 @default.
- W3048471512 cites W2269288506 @default.
- W3048471512 cites W2402936043 @default.
- W3048471512 cites W2475311184 @default.
- W3048471512 cites W2529143605 @default.
- W3048471512 cites W2603386412 @default.
- W3048471512 cites W2766907623 @default.
- W3048471512 cites W2801605713 @default.
- W3048471512 cites W2803364821 @default.
- W3048471512 cites W2884113191 @default.
- W3048471512 cites W2887288752 @default.
- W3048471512 cites W2890539106 @default.
- W3048471512 cites W2894993577 @default.
- W3048471512 cites W2904234460 @default.
- W3048471512 cites W2908299731 @default.
- W3048471512 cites W2927285401 @default.
- W3048471512 cites W4246340431 @default.
- W3048471512 cites W4256655784 @default.
- W3048471512 doi "https://doi.org/10.4093/dmj.2020.0107" @default.
- W3048471512 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8497923" @default.
- W3048471512 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32794385" @default.
- W3048471512 hasPublicationYear "2021" @default.
- W3048471512 type Work @default.
- W3048471512 sameAs 3048471512 @default.
- W3048471512 citedByCount "7" @default.
- W3048471512 countsByYear W30484715122020 @default.
- W3048471512 countsByYear W30484715122022 @default.
- W3048471512 countsByYear W30484715122023 @default.
- W3048471512 crossrefType "journal-article" @default.
- W3048471512 hasAuthorship W3048471512A5000043225 @default.
- W3048471512 hasAuthorship W3048471512A5004011057 @default.
- W3048471512 hasAuthorship W3048471512A5005659473 @default.
- W3048471512 hasAuthorship W3048471512A5006157968 @default.
- W3048471512 hasAuthorship W3048471512A5006379529 @default.
- W3048471512 hasAuthorship W3048471512A5015416322 @default.
- W3048471512 hasAuthorship W3048471512A5016285288 @default.
- W3048471512 hasAuthorship W3048471512A5018749748 @default.
- W3048471512 hasAuthorship W3048471512A5021811682 @default.
- W3048471512 hasAuthorship W3048471512A5025932754 @default.
- W3048471512 hasAuthorship W3048471512A5034642565 @default.
- W3048471512 hasAuthorship W3048471512A5034730812 @default.
- W3048471512 hasAuthorship W3048471512A5035970733 @default.
- W3048471512 hasAuthorship W3048471512A5038639550 @default.
- W3048471512 hasAuthorship W3048471512A5041198204 @default.
- W3048471512 hasAuthorship W3048471512A5042388176 @default.
- W3048471512 hasAuthorship W3048471512A5046218780 @default.
- W3048471512 hasAuthorship W3048471512A5055614488 @default.
- W3048471512 hasAuthorship W3048471512A5063076347 @default.
- W3048471512 hasAuthorship W3048471512A5067267885 @default.
- W3048471512 hasAuthorship W3048471512A5067756034 @default.
- W3048471512 hasAuthorship W3048471512A5069588636 @default.
- W3048471512 hasAuthorship W3048471512A5071399014 @default.
- W3048471512 hasAuthorship W3048471512A5079755488 @default.
- W3048471512 hasAuthorship W3048471512A5079824142 @default.