FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3048473364> ?p ?o ?g. }

• W3048473364 abstract "Abstract L-type voltage-gated calcium channels are important regulators of neuronal activity and are widely expressed throughout the brain. One of the major L-type voltage-gated calcium channel isoforms in the brain is Ca V 1.3. Mice lacking Ca V 1.3 are reported to have impairments in fear conditioning and depressive-like behaviors, which have been linked to Ca V 1.3 function in the hippocampus and amygdala. Genetic variation in Ca V 1.3 has been linked to a variety of psychiatric disorders, including autism and schizophrenia, which are associated with altered motor learning, associative learning, and social function. Here, we explored whether Ca V 1.3 plays a role in these behaviors. We found that Ca V 1.3 knockout mice have deficits in rotarod learning despite normal locomotor function. Deletion of Ca V 1.3 is also associated with impaired gait adaptation and associative learning on the Erasmus Ladder. We did not observe any impairments in Ca V 1.3 knockout mice on assays of anxiety-like, depression-like, or social preference behaviors. Our results suggest an important role for Ca V 1.3 in neural circuits involved in motor learning and concur with previous data showing its involvement in associative learning." @default.
• W3048473364 created "2020-08-18" @default.
• W3048473364 creator A5000598436 @default.
• W3048473364 creator A5021045385 @default.
• W3048473364 creator A5061125268 @default.
• W3048473364 creator A5062977023 @default.
• W3048473364 creator A5073541530 @default.
• W3048473364 creator A5075676772 @default.
• W3048473364 date "2020-08-12" @default.
• W3048473364 modified "2023-10-17" @default.
• W3048473364 title "Deletion of the voltage-gated calcium channel, CaV1.3, causes deficits in motor performance and associative learning" @default.
• W3048473364 cites W1481250329 @default.
• W3048473364 cites W1503832746 @default.
• W3048473364 cites W1506027146 @default.
• W3048473364 cites W1889411449 @default.
• W3048473364 cites W1967440935 @default.
• W3048473364 cites W1967589842 @default.
• W3048473364 cites W1970281475 @default.
• W3048473364 cites W1983803713 @default.
• W3048473364 cites W1986928970 @default.
• W3048473364 cites W1987797097 @default.
• W3048473364 cites W1993588417 @default.
• W3048473364 cites W2001996712 @default.
• W3048473364 cites W2002831258 @default.
• W3048473364 cites W2006623752 @default.
• W3048473364 cites W2010526028 @default.
• W3048473364 cites W2010900435 @default.
• W3048473364 cites W2014202857 @default.
• W3048473364 cites W2017818222 @default.
• W3048473364 cites W2021213423 @default.
• W3048473364 cites W2029706895 @default.
• W3048473364 cites W2034065320 @default.
• W3048473364 cites W2035460326 @default.
• W3048473364 cites W2035906683 @default.
• W3048473364 cites W2039395312 @default.
• W3048473364 cites W2041915741 @default.
• W3048473364 cites W2042198653 @default.
• W3048473364 cites W2077718913 @default.
• W3048473364 cites W2088677652 @default.
• W3048473364 cites W2104202813 @default.
• W3048473364 cites W2118278860 @default.
• W3048473364 cites W2131813147 @default.
• W3048473364 cites W2139852368 @default.
• W3048473364 cites W2159013601 @default.
• W3048473364 cites W2329917809 @default.
• W3048473364 cites W2414048986 @default.
• W3048473364 cites W2415940004 @default.
• W3048473364 cites W2467310893 @default.
• W3048473364 cites W2587893207 @default.
• W3048473364 cites W2611121922 @default.
• W3048473364 cites W2734601316 @default.
• W3048473364 cites W2771440806 @default.
• W3048473364 cites W2800640079 @default.
• W3048473364 cites W2885927965 @default.
• W3048473364 cites W2909287823 @default.
• W3048473364 cites W4235960403 @default.
• W3048473364 cites W765288126 @default.
• W3048473364 doi "https://doi.org/10.1101/2020.08.12.248120" @default.
• W3048473364 hasPublicationYear "2020" @default.
• W3048473364 type Work @default.
• W3048473364 sameAs 3048473364 @default.
• W3048473364 citedByCount "0" @default.
• W3048473364 crossrefType "posted-content" @default.
• W3048473364 hasAuthorship W3048473364A5000598436 @default.
• W3048473364 hasAuthorship W3048473364A5021045385 @default.
• W3048473364 hasAuthorship W3048473364A5061125268 @default.
• W3048473364 hasAuthorship W3048473364A5062977023 @default.
• W3048473364 hasAuthorship W3048473364A5073541530 @default.
• W3048473364 hasAuthorship W3048473364A5075676772 @default.
• W3048473364 hasBestOaLocation W30484733641 @default.
• W3048473364 hasConcept C104317684 @default.
• W3048473364 hasConcept C118552586 @default.
• W3048473364 hasConcept C138496976 @default.
• W3048473364 hasConcept C15744967 @default.
• W3048473364 hasConcept C16837860 @default.
• W3048473364 hasConcept C169760540 @default.
• W3048473364 hasConcept C178790620 @default.
• W3048473364 hasConcept C182704531 @default.
• W3048473364 hasConcept C185592680 @default.
• W3048473364 hasConcept C18699975 @default.
• W3048473364 hasConcept C205778803 @default.
• W3048473364 hasConcept C2776412080 @default.
• W3048473364 hasConcept C2779144063 @default.
• W3048473364 hasConcept C2781161787 @default.
• W3048473364 hasConcept C2983526489 @default.
• W3048473364 hasConcept C519063684 @default.
• W3048473364 hasConcept C55493867 @default.
• W3048473364 hasConcept C85520022 @default.
• W3048473364 hasConceptScore W3048473364C104317684 @default.
• W3048473364 hasConceptScore W3048473364C118552586 @default.
• W3048473364 hasConceptScore W3048473364C138496976 @default.
• W3048473364 hasConceptScore W3048473364C15744967 @default.
• W3048473364 hasConceptScore W3048473364C16837860 @default.
• W3048473364 hasConceptScore W3048473364C169760540 @default.
• W3048473364 hasConceptScore W3048473364C178790620 @default.
• W3048473364 hasConceptScore W3048473364C182704531 @default.
• W3048473364 hasConceptScore W3048473364C185592680 @default.
• W3048473364 hasConceptScore W3048473364C18699975 @default.
• W3048473364 hasConceptScore W3048473364C205778803 @default.
• W3048473364 hasConceptScore W3048473364C2776412080 @default.

• next