FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3048474083> ?p ?o ?g. }

• W3048474083 abstract "We previously demonstrated that seizure occurrences at different zeitgeber times alter sleep and circadian rhythm differently. On the other hand, the synchronized delta wave of electroencephalogram (EEG) during non-rapid eye movement (NREM) sleep facilitates seizure while desynchronized EEG of REM sleep suppresses it. We also elucidated that unilateral deep brain stimulation (DBS) of anterior nucleus of thalamus (ANT) suppresses seizure recurrence. In present study, we intraperitoneally injected pentylenetetrazol (PTZ, 40 mg/kg) for consecutive 14 days (PTZ kindling) to induce spontaneous seizure in rats, and a 30-minute (delivered 10-min before each PTZ injection) or a 3-hour DBS of unilateral ANT (delivered 1–h before each PTZ injection) was applied to suppress seizure. The frequency of DBS stimulation was 200 Hz and the electrical currents consisted of biphasic square pulses with an intensity of 50 μA, an 100 μs pulse width and a 4.1 ms stimulation interval. Our results found that PTZ-induced spontaneous seizure did not cause significantly change the quantity in NREM sleep, but suppressed the amount of REM sleep. Unilateral ANT DBS prolonged the onset latency of ictal seizure, decreased the spontaneous seizure duration, and increased the survival rate, but did not change the amplitudes of epileptiform EEGs during ictal period. Unilateral ANT DBS did not significantly alter NREM sleep, but increased the amounts of REM sleep. Analyzing the spectrograms of Fast Fourier Transforms (FFTs) indicated that intensities of all frequencies were enhanced during the PTZ-induced ictal period and subsequent spontaneous seizure. Thirty minutes of unilateral ANT DBS suppressed the augmentation of low-frequency (< 10 Hz) intensities during the spontaneous seizure induced by PTZ kindling. We further found that consecutive injections of PTZ progressively increased the enhancement of the delta powers during NREM sleep, whereas the unilateral ANT DBS inhibited this progressive enhancement. It was also noticed that 30-min ANT DBS exhibited better efficacy in epilepsy suppression than 3-h ANT DBS. These results elucidated that the unilateral ANT DNS enhanced the seizure threshold by increasing the amounts of REM sleep and decreasing the progressive enhancement of delta power during NREM sleep to suppress spontaneous seizure recurrences in PTZ kindling-induced epileptic rats." @default.
• W3048474083 created "2020-08-18" @default.
• W3048474083 creator A5056752106 @default.
• W3048474083 creator A5068118744 @default.
• W3048474083 creator A5073386606 @default.
• W3048474083 creator A5086957302 @default.
• W3048474083 date "2020-08-12" @default.
• W3048474083 modified "2023-10-06" @default.
• W3048474083 title "Deep Brain Stimulation Increases Seizure Threshold by Altering REM Sleep and Delta Powers During NREM Sleep" @default.
• W3048474083 cites W1527468221 @default.
• W3048474083 cites W1875008998 @default.
• W3048474083 cites W195808565 @default.
• W3048474083 cites W1965258124 @default.
• W3048474083 cites W1966617461 @default.
• W3048474083 cites W1975028926 @default.
• W3048474083 cites W1975723014 @default.
• W3048474083 cites W1976004204 @default.
• W3048474083 cites W1977172001 @default.
• W3048474083 cites W1978747821 @default.
• W3048474083 cites W1987032781 @default.
• W3048474083 cites W1991003075 @default.
• W3048474083 cites W1995296893 @default.
• W3048474083 cites W1998133274 @default.
• W3048474083 cites W2003094306 @default.
• W3048474083 cites W2015959472 @default.
• W3048474083 cites W2017524331 @default.
• W3048474083 cites W2023544660 @default.
• W3048474083 cites W2039729897 @default.
• W3048474083 cites W2040076525 @default.
• W3048474083 cites W2044192677 @default.
• W3048474083 cites W2045515449 @default.
• W3048474083 cites W2048637344 @default.
• W3048474083 cites W2062041648 @default.
• W3048474083 cites W2068106510 @default.
• W3048474083 cites W2071365886 @default.
• W3048474083 cites W2073383779 @default.
• W3048474083 cites W2086752457 @default.
• W3048474083 cites W2087307486 @default.
• W3048474083 cites W2095444980 @default.
• W3048474083 cites W2096892963 @default.
• W3048474083 cites W2105885719 @default.
• W3048474083 cites W2122431110 @default.
• W3048474083 cites W2131760028 @default.
• W3048474083 cites W2135629133 @default.
• W3048474083 cites W2167080967 @default.
• W3048474083 cites W2167758534 @default.
• W3048474083 cites W2284345796 @default.
• W3048474083 cites W2293713557 @default.
• W3048474083 cites W2559904039 @default.
• W3048474083 cites W2602582143 @default.
• W3048474083 cites W2901917033 @default.
• W3048474083 cites W2921116799 @default.
• W3048474083 cites W4255011138 @default.
• W3048474083 cites W4295332390 @default.
• W3048474083 cites W45431722 @default.
• W3048474083 doi "https://doi.org/10.3389/fneur.2020.00752" @default.
• W3048474083 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7434934" @default.
• W3048474083 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32903424" @default.
• W3048474083 hasPublicationYear "2020" @default.
• W3048474083 type Work @default.
• W3048474083 sameAs 3048474083 @default.
• W3048474083 citedByCount "6" @default.
• W3048474083 countsByYear W30484740832022 @default.
• W3048474083 countsByYear W30484740832023 @default.
• W3048474083 crossrefType "journal-article" @default.
• W3048474083 hasAuthorship W3048474083A5056752106 @default.
• W3048474083 hasAuthorship W3048474083A5068118744 @default.
• W3048474083 hasAuthorship W3048474083A5073386606 @default.
• W3048474083 hasAuthorship W3048474083A5086957302 @default.
• W3048474083 hasBestOaLocation W30484740831 @default.
• W3048474083 hasConcept C110539466 @default.
• W3048474083 hasConcept C111919701 @default.
• W3048474083 hasConcept C118552586 @default.
• W3048474083 hasConcept C126322002 @default.
• W3048474083 hasConcept C143647101 @default.
• W3048474083 hasConcept C15744967 @default.
• W3048474083 hasConcept C169760540 @default.
• W3048474083 hasConcept C17755696 @default.
• W3048474083 hasConcept C20566671 @default.
• W3048474083 hasConcept C24998067 @default.
• W3048474083 hasConcept C2775841894 @default.
• W3048474083 hasConcept C2775858608 @default.
• W3048474083 hasConcept C2776819090 @default.
• W3048474083 hasConcept C2777341932 @default.
• W3048474083 hasConcept C2778186239 @default.
• W3048474083 hasConcept C2778542668 @default.
• W3048474083 hasConcept C2779134260 @default.
• W3048474083 hasConcept C2779734285 @default.
• W3048474083 hasConcept C2781210498 @default.
• W3048474083 hasConcept C2909515847 @default.
• W3048474083 hasConcept C41008148 @default.
• W3048474083 hasConcept C42219234 @default.
• W3048474083 hasConcept C522805319 @default.
• W3048474083 hasConcept C63759246 @default.
• W3048474083 hasConcept C71924100 @default.
• W3048474083 hasConcept C84644016 @default.
• W3048474083 hasConceptScore W3048474083C110539466 @default.
• W3048474083 hasConceptScore W3048474083C111919701 @default.
• W3048474083 hasConceptScore W3048474083C118552586 @default.
• W3048474083 hasConceptScore W3048474083C126322002 @default.

• next