Matches in SemOpenAlex for { <https://semopenalex.org/work/W3048475940> ?p ?o ?g. }
- W3048475940 endingPage "3391" @default.
- W3048475940 startingPage "3378" @default.
- W3048475940 abstract "Immunogene therapy is a novel method for the treatment of colorectal cancer. Cytokine IL-15 has exhibited therapeutic anticancer potential due to its immune-stimulation property. However, conventional IL-15-based cancer gene therapy studies have been performed using the plasmid DNA form, which has potential shortcomings including weak delivery efficiency and backbone effect. In this study, an IL-15 immunogene therapy study for colon cancer using in vitro transcript mRNA is described. A protamine/liposome system (CLPP) is developed to provide efficient condensation and delivery capacity for in vivo mRNA transportation. They demonstrated that the prepared CLPP system could deliver the IL-15-encoding mRNA into C26 cells with high efficacy. The secretory expressed IL-15 cytokine by the C26 cells successfully produced lymphocyte stimulation and triggered anticancer cytotoxicity upon cancer cells in vitro. Local or systemic administration of the CLPP/mIL-15 complex exhibited obvious inhibition effects on multiple C26 murine colon cancer models with inhibition rates of up to 70% in the C26 abdominal cavity metastasis tumor model, 55% in the subcutaneous model, and 69% in the pulmonary metastasis model, demonstrating high efficacy and safety. These results successfully demonstrated the high therapeutic potential of the CLPP/mIL-15 complex for colorectal cancer immunogene therapy." @default.
- W3048475940 created "2020-08-18" @default.
- W3048475940 creator A5007171498 @default.
- W3048475940 creator A5021210072 @default.
- W3048475940 creator A5024939624 @default.
- W3048475940 creator A5033147272 @default.
- W3048475940 creator A5061425527 @default.
- W3048475940 creator A5070772379 @default.
- W3048475940 creator A5074073450 @default.
- W3048475940 creator A5084795769 @default.
- W3048475940 creator A5090403310 @default.
- W3048475940 date "2020-08-10" @default.
- W3048475940 modified "2023-10-12" @default.
- W3048475940 title "Efficient Colorectal Cancer Gene Therapy with IL-15 mRNA Nanoformulation" @default.
- W3048475940 cites W1267730164 @default.
- W3048475940 cites W1902159756 @default.
- W3048475940 cites W1963706689 @default.
- W3048475940 cites W1990399372 @default.
- W3048475940 cites W1997677868 @default.
- W3048475940 cites W1998887003 @default.
- W3048475940 cites W2003110090 @default.
- W3048475940 cites W2004239490 @default.
- W3048475940 cites W2016067417 @default.
- W3048475940 cites W2043103888 @default.
- W3048475940 cites W2055676760 @default.
- W3048475940 cites W2065061214 @default.
- W3048475940 cites W2076118796 @default.
- W3048475940 cites W2097250838 @default.
- W3048475940 cites W2104825199 @default.
- W3048475940 cites W2208560199 @default.
- W3048475940 cites W2249755146 @default.
- W3048475940 cites W2323613689 @default.
- W3048475940 cites W2396739985 @default.
- W3048475940 cites W2403783822 @default.
- W3048475940 cites W2412475928 @default.
- W3048475940 cites W2467727683 @default.
- W3048475940 cites W2618545704 @default.
- W3048475940 cites W2753829039 @default.
- W3048475940 cites W2763619988 @default.
- W3048475940 cites W2767040098 @default.
- W3048475940 cites W2779488239 @default.
- W3048475940 cites W2781525129 @default.
- W3048475940 cites W2804073175 @default.
- W3048475940 cites W2806093443 @default.
- W3048475940 cites W2808318674 @default.
- W3048475940 cites W2811204501 @default.
- W3048475940 cites W2885738433 @default.
- W3048475940 cites W2897468152 @default.
- W3048475940 cites W2910396248 @default.
- W3048475940 cites W2915035571 @default.
- W3048475940 cites W2915822971 @default.
- W3048475940 cites W2920833479 @default.
- W3048475940 cites W2940611353 @default.
- W3048475940 cites W2945795737 @default.
- W3048475940 cites W2945798418 @default.
- W3048475940 cites W2951394828 @default.
- W3048475940 cites W2952388162 @default.
- W3048475940 cites W2958582875 @default.
- W3048475940 cites W4205280733 @default.
- W3048475940 doi "https://doi.org/10.1021/acs.molpharmaceut.0c00451" @default.
- W3048475940 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32787272" @default.
- W3048475940 hasPublicationYear "2020" @default.
- W3048475940 type Work @default.
- W3048475940 sameAs 3048475940 @default.
- W3048475940 citedByCount "34" @default.
- W3048475940 countsByYear W30484759402021 @default.
- W3048475940 countsByYear W30484759402022 @default.
- W3048475940 countsByYear W30484759402023 @default.
- W3048475940 crossrefType "journal-article" @default.
- W3048475940 hasAuthorship W3048475940A5007171498 @default.
- W3048475940 hasAuthorship W3048475940A5021210072 @default.
- W3048475940 hasAuthorship W3048475940A5024939624 @default.
- W3048475940 hasAuthorship W3048475940A5033147272 @default.
- W3048475940 hasAuthorship W3048475940A5061425527 @default.
- W3048475940 hasAuthorship W3048475940A5070772379 @default.
- W3048475940 hasAuthorship W3048475940A5074073450 @default.
- W3048475940 hasAuthorship W3048475940A5084795769 @default.
- W3048475940 hasAuthorship W3048475940A5090403310 @default.
- W3048475940 hasConcept C104317684 @default.
- W3048475940 hasConcept C111599444 @default.
- W3048475940 hasConcept C121608353 @default.
- W3048475940 hasConcept C126322002 @default.
- W3048475940 hasConcept C150903083 @default.
- W3048475940 hasConcept C202751555 @default.
- W3048475940 hasConcept C203014093 @default.
- W3048475940 hasConcept C207001950 @default.
- W3048475940 hasConcept C2778690821 @default.
- W3048475940 hasConcept C2779013556 @default.
- W3048475940 hasConcept C502942594 @default.
- W3048475940 hasConcept C526805850 @default.
- W3048475940 hasConcept C55493867 @default.
- W3048475940 hasConcept C71924100 @default.
- W3048475940 hasConcept C86803240 @default.
- W3048475940 hasConcept C8891405 @default.
- W3048475940 hasConcept C96232424 @default.
- W3048475940 hasConceptScore W3048475940C104317684 @default.
- W3048475940 hasConceptScore W3048475940C111599444 @default.
- W3048475940 hasConceptScore W3048475940C121608353 @default.