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• W3048476446 startingPage "137" @default.
• W3048476446 abstract "Over the past several years, significant technological and biological progress has been made in radiation oncology with focus on the development of new treatment schemes to target tumors more precisely and increase the susceptibility of tumor cells to radiation therapy. It is essential that new treatment concepts are first appropriately evaluated and validated in preclinical settings before they are translated into the clinic. In vivo models are the most valid model systems for preclinical investigations, as they best resemble the physiological complexity needed for translational studies. For the preclinical evaluation of promising radiosensitizers, relevant clinical endpoints should be defined in order to draw the correct conclusions for clinical translation. In addition, the appropriate preclinical model should be considered (patient-derived, cell line-derived, transgenic, etc.). Local tumor control is the endpoint of choice for preclinical assessments of the efficacy of new combination treatments in radiation oncology for curative radiation-based treatment strategies. Local tumor control takes into account the potential presence of cancer stem cells that may lead to recurrence after treatment. In addition to the correct tumor model and the clinical endpoint, other factors such as tumor heterogeneity, clinically relevant treatment regimens, and the presence of predictive biomarkers must be considered to reliably evaluate novel radiosensitizers." @default.
• W3048476446 created "2020-08-18" @default.
• W3048476446 creator A5006392120 @default.
• W3048476446 creator A5039276843 @default.
• W3048476446 creator A5056888902 @default.
• W3048476446 creator A5083101824 @default.
• W3048476446 date "2020-01-01" @default.
• W3048476446 modified "2023-10-16" @default.
• W3048476446 title "Preclinical In Vivo Evaluation of Novel Radiosensitizers by Local Tumor Control Experiments" @default.
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