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• W3048476781 endingPage "101445" @default.
• W3048476781 startingPage "101445" @default.
• W3048476781 abstract "In bacteria, the dissociable σ subunit of the RNA polymerase (RNAP) is responsible for initiating RNA synthesis from specific DNA sites. As nascent RNA grows, downstream DNA unwinds and is pulled into the RNAP, causing stress accumulation and initiation complex destabilization. Processive transcription elongation requires at least partial separation of the σ factor from the RNAP core enzyme. Here, we present a series of transcription complexes captured between the early initiation and elongation phases via in-crystal RNA synthesis and cleavage. Crystal structures of these complexes indicate that stress accumulation during transcription initiation is not due to clashing of the growing nascent RNA with the σ3.2 loop, but results from scrunching of the template strand DNA that is contained inside the RNAP by the σ3 domain. Our results shed light on how scrunching of template-strand DNA drives both abortive initiation and σ-RNAP core separation to transition transcription from initiation to elongation." @default.
• W3048476781 created "2020-08-18" @default.
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• W3048476781 date "2020-09-01" @default.
• W3048476781 modified "2023-10-17" @default.
• W3048476781 title "Structural Insights into Transcription Initiation from De Novo RNA Synthesis to Transitioning into Elongation" @default.
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• W3048476781 doi "https://doi.org/10.1016/j.isci.2020.101445" @default.
• W3048476781 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7452309" @default.
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• W3048476781 hasPublicationYear "2020" @default.
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