FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3048478801> ?p ?o ?g. }

• W3048478801 abstract "Abstract Cardiac progenitor cells (CPCs), capable of differentiating into multiple cardiac cell types including cardiomyocytes (CMs), endothelial cells, and smooth muscle cells, are promising candidates for cardiac repair/regeneration. In vitro model systems where cells are grown in a more in vivo-like environment, such as 3D cultures, have been shown to be more predictive than 2D culture for studying cell biology and disease pathophysiology. In this report, we focused on using Wnt inhibitors to study the differentiation of human iPSC-CPCs under 2D or 3D culture conditions by measuring marker protein and gene expression as well as intracellular Ca 2+ oscillation. Our results show that the 3D culture with aligned nanofiber scaffolds, mimicing the architecture of the extracellular matrix of the heart, improve the differentiation of iPSC-CPCs to functional cardiomyocytes induced by Wnt inhibition, as shown with increased number of cardiac Troponin T (cTnT)-positive cells and synchronized intracellular Ca 2+ oscillation. In addition, we studied if 3D nanofiber culture can be used as an in vitro model for compound screening by testing a number of other differentiation factors including a ALK5 inhibitor and inhibitors of BMP signaling. This work highlights the importance of using a more relevant in vitro model and measuring not only the expression of marker proteins but also the functional readout in a screen in order to identify the best compounds and to investigate the resulting biology." @default.
• W3048478801 created "2020-08-18" @default.
• W3048478801 creator A5001605640 @default.
• W3048478801 creator A5007493361 @default.
• W3048478801 creator A5013822963 @default.
• W3048478801 creator A5036191289 @default.
• W3048478801 creator A5044651065 @default.
• W3048478801 creator A5046643104 @default.
• W3048478801 creator A5066637534 @default.
• W3048478801 creator A5082403139 @default.
• W3048478801 date "2020-08-11" @default.
• W3048478801 modified "2023-10-11" @default.
• W3048478801 title "Aligned nanofiber scaffolds improve functionality of cardiomyocytes differentiated from human induced pluripotent stem cell-derived cardiac progenitor cells" @default.
• W3048478801 cites W1563180177 @default.
• W3048478801 cites W1570652990 @default.
• W3048478801 cites W1815684201 @default.
• W3048478801 cites W1964281587 @default.
• W3048478801 cites W1966232780 @default.
• W3048478801 cites W1975326759 @default.
• W3048478801 cites W1976632391 @default.
• W3048478801 cites W1987787819 @default.
• W3048478801 cites W2008681436 @default.
• W3048478801 cites W2010251891 @default.
• W3048478801 cites W2020702297 @default.
• W3048478801 cites W2028826691 @default.
• W3048478801 cites W2037650349 @default.
• W3048478801 cites W2038837996 @default.
• W3048478801 cites W2038869814 @default.
• W3048478801 cites W2047266588 @default.
• W3048478801 cites W2050051758 @default.
• W3048478801 cites W2057762864 @default.
• W3048478801 cites W2078841743 @default.
• W3048478801 cites W2083599207 @default.
• W3048478801 cites W2119698183 @default.
• W3048478801 cites W2128923693 @default.
• W3048478801 cites W2129962922 @default.
• W3048478801 cites W2132088961 @default.
• W3048478801 cites W2132725083 @default.
• W3048478801 cites W2135073071 @default.
• W3048478801 cites W2137542902 @default.
• W3048478801 cites W2138580391 @default.
• W3048478801 cites W2148392331 @default.
• W3048478801 cites W2158897376 @default.
• W3048478801 cites W2164803358 @default.
• W3048478801 cites W2165316896 @default.
• W3048478801 cites W2166935014 @default.
• W3048478801 cites W2167338134 @default.
• W3048478801 cites W2197726610 @default.
• W3048478801 cites W2343304742 @default.
• W3048478801 cites W2479529989 @default.
• W3048478801 cites W2531760931 @default.
• W3048478801 cites W2735818838 @default.
• W3048478801 cites W2744657923 @default.
• W3048478801 cites W2766518358 @default.
• W3048478801 cites W2768019923 @default.
• W3048478801 cites W2768142457 @default.
• W3048478801 cites W2774069831 @default.
• W3048478801 cites W2788579133 @default.
• W3048478801 cites W2789015856 @default.
• W3048478801 cites W2810485115 @default.
• W3048478801 cites W2888880321 @default.
• W3048478801 cites W2898197535 @default.
• W3048478801 cites W3046692965 @default.
• W3048478801 cites W3150294065 @default.
• W3048478801 cites W4206346630 @default.
• W3048478801 cites W4211016865 @default.
• W3048478801 cites W871856417 @default.
• W3048478801 doi "https://doi.org/10.1038/s41598-020-70547-4" @default.
• W3048478801 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7419298" @default.
• W3048478801 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32782331" @default.
• W3048478801 hasPublicationYear "2020" @default.
• W3048478801 type Work @default.
• W3048478801 sameAs 3048478801 @default.
• W3048478801 citedByCount "29" @default.
• W3048478801 countsByYear W30484788012020 @default.
• W3048478801 countsByYear W30484788012021 @default.
• W3048478801 countsByYear W30484788012022 @default.
• W3048478801 countsByYear W30484788012023 @default.
• W3048478801 crossrefType "journal-article" @default.
• W3048478801 hasAuthorship W3048478801A5001605640 @default.
• W3048478801 hasAuthorship W3048478801A5007493361 @default.
• W3048478801 hasAuthorship W3048478801A5013822963 @default.
• W3048478801 hasAuthorship W3048478801A5036191289 @default.
• W3048478801 hasAuthorship W3048478801A5044651065 @default.
• W3048478801 hasAuthorship W3048478801A5046643104 @default.
• W3048478801 hasAuthorship W3048478801A5066637534 @default.
• W3048478801 hasAuthorship W3048478801A5082403139 @default.
• W3048478801 hasBestOaLocation W30484788011 @default.
• W3048478801 hasConcept C104317684 @default.
• W3048478801 hasConcept C107459253 @default.
• W3048478801 hasConcept C126322002 @default.
• W3048478801 hasConcept C137620995 @default.
• W3048478801 hasConcept C145103041 @default.
• W3048478801 hasConcept C148738053 @default.
• W3048478801 hasConcept C185592680 @default.
• W3048478801 hasConcept C189165786 @default.
• W3048478801 hasConcept C201750760 @default.
• W3048478801 hasConcept C202751555 @default.
• W3048478801 hasConcept C207200792 @default.
• W3048478801 hasConcept C2778532138 @default.

• next