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- W3048489860 abstract "INNOVANCE® VWF Acは血小板膜糖蛋白質GPIbの変異体を用いるフォンヴィレブランド因子（von Willebrand factor: VWF）活性（VWF:GPIbM）測定試薬である．本研究では本邦で初めてその基本性能評価を行った．併行精度はCVが3％未満，室内再現性はCVが2％未満と良好な成績であった．希釈直線性も良好であり，最小検出感度は1.3 IU/dLであった．また，干渉物質や未分画ヘパリン混入による明らかな影響は見られなかった．正常検体100例を用いた相関性試験ではVWF抗原量およびVWFリストセチンコファクター活性（VWF:RCo）と良好な相関性を示した．フォンヴィレブランド病患者検体においてもVWF:RCoとの測定値に大きな差はなく，VWF:GPIbMでは特に低濃度域を評価することが可能であった．INNOVANCE® VWF AcはVWF:RCo測定試薬と比べても高い性能を有することが明らかとなった．" @default.
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- W3048489860 date "2020-01-01" @default.
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- W3048489860 title "Performance Evaluation of INNOVANCE<sup>®</sup> VWF Ac Assay employing recombinant glycoprotein Ib mutant" @default.
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