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- W3048491903 endingPage "e1008707" @default.
- W3048491903 startingPage "e1008707" @default.
- W3048491903 abstract "Proteus mirabilis, a Gram-negative uropathogen, is a major causative agent in catheter-associated urinary tract infections (CAUTI). Mannose-resistant Proteus-like fimbriae (MR/P) are crucially important for P. mirabilis infectivity and are required for biofilm formation and auto-aggregation, as well as for bladder and kidney colonization. Here, the X-ray crystal structure of the MR/P tip adhesin, MrpH, is reported. The structure has a fold not previously described and contains a transition metal center with Zn2+ coordinated by three conserved histidine residues and a ligand. Using biofilm assays, chelation, metal complementation, and site-directed mutagenesis of the three histidines, we show that an intact metal binding site occupied by zinc is essential for MR/P fimbria-mediated biofilm formation, and furthermore, that P. mirabilis biofilm formation is reversible in a zinc-dependent manner. Zinc is also required for MR/P-dependent agglutination of erythrocytes, and mutation of the metal binding site renders P. mirabilis unfit in a mouse model of UTI. The studies presented here provide important clues as to the mechanism of MR/P-mediated biofilm formation and serve as a starting point for identifying the physiological MR/P fimbrial receptor." @default.
- W3048491903 created "2020-08-18" @default.
- W3048491903 creator A5004676213 @default.
- W3048491903 creator A5006179322 @default.
- W3048491903 creator A5007507581 @default.
- W3048491903 creator A5007679233 @default.
- W3048491903 creator A5024812408 @default.
- W3048491903 creator A5047543270 @default.
- W3048491903 creator A5073472076 @default.
- W3048491903 creator A5074965131 @default.
- W3048491903 date "2020-08-11" @default.
- W3048491903 modified "2023-10-10" @default.
- W3048491903 title "MrpH, a new class of metal-binding adhesin, requires zinc to mediate biofilm formation" @default.
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