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- W3048492407 endingPage "997" @default.
- W3048492407 startingPage "986" @default.
- W3048492407 abstract "Dynamic proteins perform critical roles in cellular machines, including those that control proteostasis, transcription, translation, and signaling. Thus, dynamic proteins are prime candidates for chemical probe and drug discovery but difficult targets because they do not conform to classical rules of design and screening. Selectivity is pivotal for candidate probe molecules due to the extensive interaction network of these dynamic hubs. Recognition that the traditional rules of probe discovery are not necessarily applicable to dynamic proteins and their complexes, as well as technological advances in screening, have produced remarkable results in the last 2–4 years. Particularly notable are the improvements in target selectivity for small-molecule modulators of dynamic proteins, especially with techniques that increase the discovery likelihood of allosteric regulatory mechanisms. We focus on approaches to small-molecule screening that appear to be more suitable for highly dynamic targets and have the potential to streamline identification of selective modulators." @default.
- W3048492407 created "2020-08-18" @default.
- W3048492407 creator A5075283440 @default.
- W3048492407 creator A5089941665 @default.
- W3048492407 date "2020-08-01" @default.
- W3048492407 modified "2023-10-16" @default.
- W3048492407 title "Selective Modulation of Dynamic Protein Complexes" @default.
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