Matches in SemOpenAlex for { <https://semopenalex.org/work/W3048493026> ?p ?o ?g. }
- W3048493026 abstract "Polyphosphates are linear polymers and ubiquitous metabolites. Bacterial polyphosphates are long chains of hundreds of phosphate units. Here, we report that mouse survival of peritoneal Escherichia coli sepsis is compromised by long-chain polyphosphates, and improves with bacterial polyphosphatekinase deficiency or neutralization using recombinant exopolyphosphatase. Polyphosphate activities are chain-length dependent, impair pathogen clearance, antagonize phagocyte recruitment, diminish phagocytosis and decrease production of iNOS and cytokines. Macrophages bind and internalize polyphosphates, in which their effects are independent of P2Y1 and RAGE receptors. The M1 polarization driven by E. coli derived LPS is misdirected by polyphosphates in favor of an M2 resembling phenotype. Long-chain polyphosphates modulate the expression of more than 1800 LPS/TLR4-regulated genes in macrophages. This interference includes suppression of hundreds of type I interferon-regulated genes due to lower interferon production and responsiveness, blunted STAT1 phosphorylation and reduced MHCII expression. In conclusion, prokaryotic polyphosphates disturb multiple macrophage functions for evading host immunity." @default.
- W3048493026 created "2020-08-18" @default.
- W3048493026 creator A5016041137 @default.
- W3048493026 creator A5016772245 @default.
- W3048493026 creator A5017861039 @default.
- W3048493026 creator A5029171777 @default.
- W3048493026 creator A5035283624 @default.
- W3048493026 creator A5039399550 @default.
- W3048493026 creator A5060771191 @default.
- W3048493026 creator A5063788450 @default.
- W3048493026 creator A5080935177 @default.
- W3048493026 creator A5082893662 @default.
- W3048493026 creator A5085434133 @default.
- W3048493026 creator A5087884887 @default.
- W3048493026 creator A5088392460 @default.
- W3048493026 date "2020-08-12" @default.
- W3048493026 modified "2023-10-12" @default.
- W3048493026 title "Bacterial polyphosphates interfere with the innate host defense to infection" @default.
- W3048493026 cites W1506314131 @default.
- W3048493026 cites W1589342505 @default.
- W3048493026 cites W1642671236 @default.
- W3048493026 cites W1837038410 @default.
- W3048493026 cites W1933778251 @default.
- W3048493026 cites W1962869168 @default.
- W3048493026 cites W1968468186 @default.
- W3048493026 cites W1981056531 @default.
- W3048493026 cites W1985859986 @default.
- W3048493026 cites W1987200107 @default.
- W3048493026 cites W2002586970 @default.
- W3048493026 cites W2004829503 @default.
- W3048493026 cites W2018289835 @default.
- W3048493026 cites W2018972715 @default.
- W3048493026 cites W2027954222 @default.
- W3048493026 cites W2029396930 @default.
- W3048493026 cites W2039560970 @default.
- W3048493026 cites W2041195097 @default.
- W3048493026 cites W2044055017 @default.
- W3048493026 cites W2064232485 @default.
- W3048493026 cites W2070855360 @default.
- W3048493026 cites W2076669998 @default.
- W3048493026 cites W2076684617 @default.
- W3048493026 cites W2079132877 @default.
- W3048493026 cites W2079357798 @default.
- W3048493026 cites W2079553299 @default.
- W3048493026 cites W2080196545 @default.
- W3048493026 cites W2083884362 @default.
- W3048493026 cites W2084964187 @default.
- W3048493026 cites W2094524631 @default.
- W3048493026 cites W2100837269 @default.
- W3048493026 cites W2100876879 @default.
- W3048493026 cites W2103017472 @default.
- W3048493026 cites W2107277218 @default.
- W3048493026 cites W2120024428 @default.
- W3048493026 cites W2123233366 @default.
- W3048493026 cites W2125308047 @default.
- W3048493026 cites W2128295561 @default.
- W3048493026 cites W2136091793 @default.
- W3048493026 cites W2145301793 @default.
- W3048493026 cites W2155443888 @default.
- W3048493026 cites W2157917186 @default.
- W3048493026 cites W2166617377 @default.
- W3048493026 cites W2209250550 @default.
- W3048493026 cites W2268970057 @default.
- W3048493026 cites W2418688677 @default.
- W3048493026 cites W2429977049 @default.
- W3048493026 cites W2464717012 @default.
- W3048493026 cites W2474916704 @default.
- W3048493026 cites W2514403004 @default.
- W3048493026 cites W2568982082 @default.
- W3048493026 cites W2580936711 @default.
- W3048493026 cites W2619235935 @default.
- W3048493026 cites W2729123452 @default.
- W3048493026 cites W2749954353 @default.
- W3048493026 cites W2753051611 @default.
- W3048493026 cites W2782359398 @default.
- W3048493026 cites W2809261871 @default.
- W3048493026 cites W2889754070 @default.
- W3048493026 cites W2891878357 @default.
- W3048493026 cites W2901009838 @default.
- W3048493026 cites W2901847480 @default.
- W3048493026 cites W2948494607 @default.
- W3048493026 cites W2950752563 @default.
- W3048493026 cites W2998853022 @default.
- W3048493026 cites W3000008095 @default.
- W3048493026 doi "https://doi.org/10.1038/s41467-020-17639-x" @default.
- W3048493026 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7423913" @default.
- W3048493026 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32788578" @default.
- W3048493026 hasPublicationYear "2020" @default.
- W3048493026 type Work @default.
- W3048493026 sameAs 3048493026 @default.
- W3048493026 citedByCount "59" @default.
- W3048493026 countsByYear W30484930262020 @default.
- W3048493026 countsByYear W30484930262021 @default.
- W3048493026 countsByYear W30484930262022 @default.
- W3048493026 countsByYear W30484930262023 @default.
- W3048493026 crossrefType "journal-article" @default.
- W3048493026 hasAuthorship W3048493026A5016041137 @default.
- W3048493026 hasAuthorship W3048493026A5016772245 @default.
- W3048493026 hasAuthorship W3048493026A5017861039 @default.
- W3048493026 hasAuthorship W3048493026A5029171777 @default.