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- W3048499400 endingPage "1238" @default.
- W3048499400 startingPage "1230" @default.
- W3048499400 abstract "The liver is a highly regenerative organ, but its regenerative capacity is compromised in severe liver diseases. Hepatocyte-driven liver regeneration that involves the proliferation of preexisting hepatocytes is a primary regeneration mode. On the other hand, liver progenitor cell (LPC)-driven liver regeneration that involves dedifferentiation of biliary epithelial cells or hepatocytes into LPCs, LPC proliferation, and subsequent differentiation of LPCs into hepatocytes is a secondary mode. This secondary mode plays a significant role in liver regeneration when the primary mode does not effectively work, as observed in severe liver injury settings. Thus, promoting LPC-driven liver regeneration may be clinically beneficial to patients with severe liver diseases. In this review, we describe the current understanding of LPC-driven liver regeneration by exploring current knowledge on the activation, origin, and roles of LPCs during regeneration. We also describe animal models used to study LPC-driven liver regeneration, given their potential to further deepen our understanding of the regeneration process. This understanding will eventually contribute to developing strategies to promote LPC-driven liver regeneration in patients with severe liver diseases." @default.
- W3048499400 created "2020-08-18" @default.
- W3048499400 creator A5007310584 @default.
- W3048499400 creator A5013543270 @default.
- W3048499400 creator A5050841050 @default.
- W3048499400 creator A5076275905 @default.
- W3048499400 date "2020-08-01" @default.
- W3048499400 modified "2023-10-17" @default.
- W3048499400 title "Liver progenitor cell-driven liver regeneration" @default.
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