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- W3048499705 endingPage "116003" @default.
- W3048499705 startingPage "116003" @default.
- W3048499705 abstract "Nowadays, miniaturized liquid chromatography (LC) coupled to mass spectrometry is a leading analytical technique in several modern research areas. Its applications will keep in constant spreading, and new and miniaturized instrumental advances will continue to be necessary for the coming years. In this way, chip-based LC–MS technology is one of the most efficient strategies to i) address the extra column band broadening challenges of the capillary/nanoscale, and ii) provide portability, lower-cost and user-friendly character to the miniaturized LC–MS systems. Several commercial chip-based LC–MS are available, because of the notable developments in the manufacturing of the analytical chips throughout the last decades. Since the emerging of the first instruments based on MEMS LC–MS (microelectromechanical systems), diverse microfabrication technologies have been reported to engrave and model a wide gamma of materials and substrates. Within such a context, many strategies to on-chip fully-integration of the solvent delivering systems, injectors, chromatographic media, mass spectrometry interfaces, ionization sources, and mass analyzers have been explored and its feasibility demonstrated. Herein, we provide a comprehensive overview of the major chip technology developments, their state-of-art, and a consistent survey of the recent literature on it. Finally, a description about the most diverse applications of the fully integrated chip-based LC–MS platforms is summarized. In this case, showing remarkable examples using mono and bidirectional systems to the analysis of macro- and small molecules of biochemical, biological, pharmaceutical, clinical, forensic, environmental, foodstuff and quality control interest." @default.
- W3048499705 created "2020-08-18" @default.
- W3048499705 creator A5070214973 @default.
- W3048499705 creator A5087057938 @default.
- W3048499705 creator A5091703919 @default.
- W3048499705 date "2020-10-01" @default.
- W3048499705 modified "2023-10-14" @default.
- W3048499705 title "Miniaturization of liquid chromatography coupled to mass spectrometry. 3. Achievements on chip-based LC–MS devices" @default.
- W3048499705 cites W1457811805 @default.
- W3048499705 cites W1879316774 @default.
- W3048499705 cites W194427018 @default.
- W3048499705 cites W1965613194 @default.
- W3048499705 cites W1966467244 @default.
- W3048499705 cites W1972140003 @default.
- W3048499705 cites W1973534876 @default.
- W3048499705 cites W1973753936 @default.
- W3048499705 cites W1977236778 @default.
- W3048499705 cites W1983097347 @default.
- W3048499705 cites W1990999919 @default.
- W3048499705 cites W1992199374 @default.
- W3048499705 cites W1992482245 @default.
- W3048499705 cites W1992846081 @default.
- W3048499705 cites W2002500236 @default.
- W3048499705 cites W2003203096 @default.
- W3048499705 cites W2003669744 @default.
- W3048499705 cites W2006241246 @default.
- W3048499705 cites W2008380163 @default.
- W3048499705 cites W2011086559 @default.
- W3048499705 cites W2011997839 @default.
- W3048499705 cites W2014797808 @default.
- W3048499705 cites W2019069395 @default.
- W3048499705 cites W2020151441 @default.
- W3048499705 cites W2025823888 @default.
- W3048499705 cites W2027259751 @default.
- W3048499705 cites W2029024859 @default.
- W3048499705 cites W2029171409 @default.
- W3048499705 cites W2030231504 @default.
- W3048499705 cites W2031843548 @default.
- W3048499705 cites W2033991731 @default.
- W3048499705 cites W2035159723 @default.
- W3048499705 cites W2037706845 @default.
- W3048499705 cites W2038330400 @default.
- W3048499705 cites W2045346591 @default.
- W3048499705 cites W2047838962 @default.
- W3048499705 cites W2050682399 @default.
- W3048499705 cites W2053801178 @default.
- W3048499705 cites W2053944733 @default.
- W3048499705 cites W2054911521 @default.
- W3048499705 cites W2055155998 @default.
- W3048499705 cites W2055886903 @default.
- W3048499705 cites W2056779899 @default.
- W3048499705 cites W2057864323 @default.
- W3048499705 cites W2058352484 @default.
- W3048499705 cites W2072582547 @default.
- W3048499705 cites W2072781870 @default.
- W3048499705 cites W2073622317 @default.
- W3048499705 cites W2077328434 @default.
- W3048499705 cites W2079751669 @default.
- W3048499705 cites W2080932811 @default.
- W3048499705 cites W2081147651 @default.
- W3048499705 cites W2083463959 @default.
- W3048499705 cites W2084066368 @default.
- W3048499705 cites W2090212988 @default.
- W3048499705 cites W2091380860 @default.
- W3048499705 cites W2092246020 @default.
- W3048499705 cites W2094396522 @default.
- W3048499705 cites W2095293080 @default.
- W3048499705 cites W2099354100 @default.
- W3048499705 cites W2102265050 @default.
- W3048499705 cites W2122509205 @default.
- W3048499705 cites W2125824345 @default.
- W3048499705 cites W2127538459 @default.
- W3048499705 cites W2139712155 @default.
- W3048499705 cites W2139842393 @default.
- W3048499705 cites W2142158448 @default.
- W3048499705 cites W2146417941 @default.
- W3048499705 cites W2147012519 @default.
- W3048499705 cites W2148794107 @default.
- W3048499705 cites W2155558269 @default.
- W3048499705 cites W2162090836 @default.
- W3048499705 cites W2165652044 @default.
- W3048499705 cites W2169641446 @default.
- W3048499705 cites W2171563750 @default.
- W3048499705 cites W2175780827 @default.
- W3048499705 cites W2190551284 @default.
- W3048499705 cites W2204336450 @default.
- W3048499705 cites W2230183559 @default.
- W3048499705 cites W2235660015 @default.
- W3048499705 cites W2272992058 @default.
- W3048499705 cites W2324777996 @default.
- W3048499705 cites W2331457993 @default.
- W3048499705 cites W2341738751 @default.
- W3048499705 cites W2346914565 @default.
- W3048499705 cites W2395042278 @default.
- W3048499705 cites W2408817711 @default.
- W3048499705 cites W2411881615 @default.
- W3048499705 cites W2473237467 @default.
- W3048499705 cites W2500720496 @default.