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• W3048506405 abstract "Abstract Linkage and association mapping populations are crucial public resources that facilitate the characterization of trait genetic architecture in natural and agricultural systems. We define a large nested association mapping panel (NAM) from 14 publicly available recombinant inbred line populations (RILs) of Arabidopsis thaliana, which share a common recurrent parent (Col-0). Using a genotype-by-sequencing approach (GBS), we identified single nucleotide polymorphisms (SNPs; range 563-1525 per population) and subsequently built updated linkage maps in each of the 14 RIL sets. Simulations in individual RIL populations indicate that our GBS markers have improved power to detect small effect QTL and enhanced resolution of QTL support intervals in comparison to original linkage maps. Using these robust linkage maps, we imputed a common set of publicly available parental SNPs into each RIL linkage map, generating overlapping markers across all populations. Though ultimately depending on allele frequencies at causal loci, simulations of the NAM panel suggest that surveying between 4 to 7 of the 14 RIL populations provides high resolution of the genetic architecture of complex traits, relative to a single mapping population." @default.
• W3048506405 created "2020-08-18" @default.
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• W3048506405 date "2020-10-01" @default.
• W3048506405 modified "2023-09-27" @default.
• W3048506405 title "A Nested Association Mapping Panel in <i>Arabidopsis thaliana</i> for Mapping and Characterizing Genetic Architecture" @default.
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• W3048506405 doi "https://doi.org/10.1534/g3.120.401239" @default.
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