Matches in SemOpenAlex for { <https://semopenalex.org/work/W3048507916> ?p ?o ?g. }
- W3048507916 endingPage "1415" @default.
- W3048507916 startingPage "1402" @default.
- W3048507916 abstract "The aim of this research was to develop lamotrigine containing thermosetting hydrogel for intranasal administration to manage and treat generalized epilepsy. Thermosetting hydrogels were prepared using different ratios of poloxamer 407 (L127), poloxamer 188 (L68) and Carbopol® 974 P NF (C974) using the cold production process. The in situ thermosetting hydrogel was optimized using Box Behken design. Co-solvency approach was used to increase the solubility of lamotrigine by dissolving it in propylene glycol and polyethylene glycol 400 (0.2: 0.8) and the resultant solution was incorporated in the hydrogel to manufacture an LTG hydrogel. The presence of a higher amount of L127 resulted in higher viscosity at 22 °C and 34 °C and decreased the overall release of LTG. An increase in the amount of C974 resulted in a decrease in the pH of the hydrogel. The results show that formulations F10, F12, F13, F14, F15, F16 and F17 exhibited acceptable thermosetting behavior, pH and released adequate Lamotrigine above the minimum effective concentration to treat generalized epilepsy. The optimized formulation exhibited acceptable thermosetting behavior, pH and lamotrigine release but formed a stiff gel at 22 °C. The average LTG content of the optimized hydrogel was 5.00 ± 0.0225 mg/ml with % recovery of 99.17%. The amount of LTG released at 12 h from the optimized hydrogel was 3.21 ± 0.0155 mg and will be therapeutically effective in the brain after absorption via the olfactory region in the nasal cavity." @default.
- W3048507916 created "2020-08-18" @default.
- W3048507916 creator A5049444852 @default.
- W3048507916 creator A5056566363 @default.
- W3048507916 creator A5078464335 @default.
- W3048507916 date "2020-08-21" @default.
- W3048507916 modified "2023-10-16" @default.
- W3048507916 title "Formulation optimization of smart thermosetting lamotrigine loaded hydrogels using response surface methodology, box benhken design and artificial neural networks" @default.
- W3048507916 cites W1552095323 @default.
- W3048507916 cites W1964612361 @default.
- W3048507916 cites W1972810259 @default.
- W3048507916 cites W1975440733 @default.
- W3048507916 cites W1976236482 @default.
- W3048507916 cites W1977072597 @default.
- W3048507916 cites W1980535921 @default.
- W3048507916 cites W1982955268 @default.
- W3048507916 cites W1983269317 @default.
- W3048507916 cites W1983473009 @default.
- W3048507916 cites W1985513703 @default.
- W3048507916 cites W1990550671 @default.
- W3048507916 cites W2002605614 @default.
- W3048507916 cites W2009264320 @default.
- W3048507916 cites W2009348437 @default.
- W3048507916 cites W2015377084 @default.
- W3048507916 cites W2025509004 @default.
- W3048507916 cites W2025672323 @default.
- W3048507916 cites W2034792164 @default.
- W3048507916 cites W2035085066 @default.
- W3048507916 cites W2036226379 @default.
- W3048507916 cites W2036700491 @default.
- W3048507916 cites W2051575873 @default.
- W3048507916 cites W2062293629 @default.
- W3048507916 cites W2066029389 @default.
- W3048507916 cites W2068187371 @default.
- W3048507916 cites W2072069166 @default.
- W3048507916 cites W2085316238 @default.
- W3048507916 cites W2086130473 @default.
- W3048507916 cites W2087496871 @default.
- W3048507916 cites W2095969440 @default.
- W3048507916 cites W2100847075 @default.
- W3048507916 cites W2102917770 @default.
- W3048507916 cites W2107137470 @default.
- W3048507916 cites W2162752807 @default.
- W3048507916 cites W2196359766 @default.
- W3048507916 cites W2333539750 @default.
- W3048507916 cites W2522210055 @default.
- W3048507916 cites W2548758651 @default.
- W3048507916 cites W271247119 @default.
- W3048507916 cites W2735483796 @default.
- W3048507916 cites W2765264352 @default.
- W3048507916 cites W2776146933 @default.
- W3048507916 cites W2890941429 @default.
- W3048507916 cites W2891083159 @default.
- W3048507916 cites W2980875688 @default.
- W3048507916 cites W329276326 @default.
- W3048507916 cites W4238408101 @default.
- W3048507916 cites W4239075742 @default.
- W3048507916 cites W4255484681 @default.
- W3048507916 cites W4376595446 @default.
- W3048507916 cites W83438241 @default.
- W3048507916 doi "https://doi.org/10.1080/03639045.2020.1791163" @default.
- W3048507916 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32795107" @default.
- W3048507916 hasPublicationYear "2020" @default.
- W3048507916 type Work @default.
- W3048507916 sameAs 3048507916 @default.
- W3048507916 citedByCount "4" @default.
- W3048507916 countsByYear W30485079162022 @default.
- W3048507916 countsByYear W30485079162023 @default.
- W3048507916 crossrefType "journal-article" @default.
- W3048507916 hasAuthorship W3048507916A5049444852 @default.
- W3048507916 hasAuthorship W3048507916A5056566363 @default.
- W3048507916 hasAuthorship W3048507916A5078464335 @default.
- W3048507916 hasConcept C101335993 @default.
- W3048507916 hasConcept C108586683 @default.
- W3048507916 hasConcept C118552586 @default.
- W3048507916 hasConcept C125287762 @default.
- W3048507916 hasConcept C15920480 @default.
- W3048507916 hasConcept C159985019 @default.
- W3048507916 hasConcept C171359207 @default.
- W3048507916 hasConcept C178790620 @default.
- W3048507916 hasConcept C185592680 @default.
- W3048507916 hasConcept C188027245 @default.
- W3048507916 hasConcept C192562407 @default.
- W3048507916 hasConcept C2778186239 @default.
- W3048507916 hasConcept C2778802184 @default.
- W3048507916 hasConcept C521977710 @default.
- W3048507916 hasConcept C71924100 @default.
- W3048507916 hasConceptScore W3048507916C101335993 @default.
- W3048507916 hasConceptScore W3048507916C108586683 @default.
- W3048507916 hasConceptScore W3048507916C118552586 @default.
- W3048507916 hasConceptScore W3048507916C125287762 @default.
- W3048507916 hasConceptScore W3048507916C15920480 @default.
- W3048507916 hasConceptScore W3048507916C159985019 @default.
- W3048507916 hasConceptScore W3048507916C171359207 @default.
- W3048507916 hasConceptScore W3048507916C178790620 @default.
- W3048507916 hasConceptScore W3048507916C185592680 @default.
- W3048507916 hasConceptScore W3048507916C188027245 @default.
- W3048507916 hasConceptScore W3048507916C192562407 @default.