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- W3048511092 startingPage "101454" @default.
- W3048511092 abstract "During an immune response, natural killer (NK) cells activate specific metabolic pathways to meet the increased energetic and biosynthetic demands associated with effector functions. Here, we found in vivo activation of NK cells during Listeria monocytogenes infection-augmented transcription of genes encoding mitochondria-associated proteins in a manner dependent on the transcriptional coactivator PGC-1α. Using an Ncr1Cre-based conditional knockout mouse, we found that PGC-1α was crucial for optimal NK cell effector functions and bioenergetics, as the deletion of PGC-1α was associated with decreased cytotoxic potential and cytokine production along with altered ADP/ATP ratios. Lack of PGC-1α also significantly impaired the ability of NK cells to control B16F10 tumor growth in vivo, and subsequent gene expression analysis showed that PGC-1α mediates transcription required to maintain mitochondrial activity within the tumor microenvironment. Together, these data suggest that PGC-1α-dependent transcription of specific target genes is required for optimal NK cell function during the response to infection or tumor growth." @default.
- W3048511092 created "2020-08-18" @default.
- W3048511092 creator A5000129896 @default.
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- W3048511092 creator A5071342682 @default.
- W3048511092 date "2020-09-01" @default.
- W3048511092 modified "2023-10-12" @default.
- W3048511092 title "Conditional Deletion of PGC-1α Results in Energetic and Functional Defects in NK Cells" @default.
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