FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3048513378> ?p ?o ?g. }

• W3048513378 endingPage "145" @default.
• W3048513378 startingPage "134" @default.
• W3048513378 abstract "Targeting Hedgehog (Hh) pathway components, such as Smoothened (SMO), is a developing strategy for the treatment of acute myeloid leukemia (AML) and for overcoming relapsed/refractory forms of this disease. Several SMO inhibitors are in clinical development for the treatment of various tumor types and the results from some clinical trials in AML have been reported. This review will discuss the role of Hh signaling in AML pathogenesis, describe the preclinical and clinical development of Hh pathway inhibitors for the treatment of AML, and examine the current evidence on Hh pathway inhibitor resistance and the implications for treatment selection in AML.In acute myeloid leukemia (AML), components of the Hedgehog (Hh) signaling pathway, such as Smoothened (SMO), have been implicated in the development, maintenance, and expansion of leukemic stem cells (LSC), as well as sensitization to chemotherapy and the development of drug resistance in AML. Observations in preclinical studies of AML, as well as from samples of patients with AML, demonstrate that Hh pathway inhibitors act primarily on the stem cell pathway as differentiation agents. The current data for hematologic malignancies indicate the potential for a synergistic effect when a Hh pathway inhibitor is administered in combination with chemotherapy or investigational agents. It is thought that Hh pathway inhibitors act as agents that reduce LSC dormancy and promote LSC differentiation, thus the newly dividing LSCs can then be targeted by other chemotherapeutic drugs." @default.
• W3048513378 created "2020-08-18" @default.
• W3048513378 creator A5015101485 @default.
• W3048513378 creator A5030193536 @default.
• W3048513378 creator A5044624520 @default.
• W3048513378 creator A5073761054 @default.
• W3048513378 date "2020-08-11" @default.
• W3048513378 modified "2023-10-15" @default.
• W3048513378 title "Hedgehog Pathway Inhibitors: A New Therapeutic Class for the Treatment of Acute Myeloid Leukemia" @default.
• W3048513378 cites W1023606036 @default.
• W3048513378 cites W1916873495 @default.
• W3048513378 cites W1966043852 @default.
• W3048513378 cites W1980798201 @default.
• W3048513378 cites W1983108286 @default.
• W3048513378 cites W1995143994 @default.
• W3048513378 cites W2000763030 @default.
• W3048513378 cites W2007765039 @default.
• W3048513378 cites W2010237337 @default.
• W3048513378 cites W2015303096 @default.
• W3048513378 cites W2027034464 @default.
• W3048513378 cites W2029431452 @default.
• W3048513378 cites W2057671045 @default.
• W3048513378 cites W2057784738 @default.
• W3048513378 cites W2064890881 @default.
• W3048513378 cites W2065292797 @default.
• W3048513378 cites W2084667421 @default.
• W3048513378 cites W2088811912 @default.
• W3048513378 cites W2099663271 @default.
• W3048513378 cites W2107503279 @default.
• W3048513378 cites W2108444995 @default.
• W3048513378 cites W2110321605 @default.
• W3048513378 cites W2116936012 @default.
• W3048513378 cites W2117328669 @default.
• W3048513378 cites W2120010339 @default.
• W3048513378 cites W2121998739 @default.
• W3048513378 cites W2128175263 @default.
• W3048513378 cites W2140231410 @default.
• W3048513378 cites W2158485926 @default.
• W3048513378 cites W2168373302 @default.
• W3048513378 cites W2168591146 @default.
• W3048513378 cites W2171874387 @default.
• W3048513378 cites W2240399463 @default.
• W3048513378 cites W2294157538 @default.
• W3048513378 cites W2312048098 @default.
• W3048513378 cites W2338801484 @default.
• W3048513378 cites W2345368403 @default.
• W3048513378 cites W2474599166 @default.
• W3048513378 cites W2502718344 @default.
• W3048513378 cites W2526421941 @default.
• W3048513378 cites W2551913948 @default.
• W3048513378 cites W2553680812 @default.
• W3048513378 cites W2559537906 @default.
• W3048513378 cites W2582224676 @default.
• W3048513378 cites W2583580745 @default.
• W3048513378 cites W2585283489 @default.
• W3048513378 cites W2585315580 @default.
• W3048513378 cites W2590271489 @default.
• W3048513378 cites W2612339703 @default.
• W3048513378 cites W2619953469 @default.
• W3048513378 cites W2673478615 @default.
• W3048513378 cites W2766503305 @default.
• W3048513378 cites W2770323050 @default.
• W3048513378 cites W2792568261 @default.
• W3048513378 cites W2792707179 @default.
• W3048513378 cites W2792970162 @default.
• W3048513378 cites W2794046507 @default.
• W3048513378 cites W2887055543 @default.
• W3048513378 cites W2889113760 @default.
• W3048513378 cites W2889880782 @default.
• W3048513378 cites W2891826418 @default.
• W3048513378 cites W2903832621 @default.
• W3048513378 cites W2905344869 @default.
• W3048513378 cites W2989737435 @default.
• W3048513378 cites W3008846183 @default.
• W3048513378 doi "https://doi.org/10.1158/2643-3230.bcd-20-0007" @default.
• W3048513378 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8447269" @default.
• W3048513378 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34661144" @default.
• W3048513378 hasPublicationYear "2020" @default.
• W3048513378 type Work @default.
• W3048513378 sameAs 3048513378 @default.
• W3048513378 citedByCount "39" @default.
• W3048513378 countsByYear W30485133782021 @default.
• W3048513378 countsByYear W30485133782022 @default.
• W3048513378 countsByYear W30485133782023 @default.
• W3048513378 crossrefType "journal-article" @default.
• W3048513378 hasAuthorship W3048513378A5015101485 @default.
• W3048513378 hasAuthorship W3048513378A5030193536 @default.
• W3048513378 hasAuthorship W3048513378A5044624520 @default.
• W3048513378 hasAuthorship W3048513378A5073761054 @default.
• W3048513378 hasBestOaLocation W30485133781 @default.
• W3048513378 hasConcept C145837895 @default.
• W3048513378 hasConcept C203014093 @default.
• W3048513378 hasConcept C2778461978 @default.
• W3048513378 hasConcept C2778539099 @default.
• W3048513378 hasConcept C2778729363 @default.
• W3048513378 hasConcept C2779282312 @default.
• W3048513378 hasConcept C502942594 @default.
• W3048513378 hasConcept C55493867 @default.

• next