FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3048520309> ?p ?o ?g. }

• W3048520309 endingPage "595" @default.
• W3048520309 startingPage "588" @default.
• W3048520309 abstract "Coronavirus Disease 2019 (COVID-19) is a dangerous global threat that has no clinically approved treatment yet. Bioinformatics represent an outstanding approach to reveal key immunogenic regions in viral proteins. Here, five severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) non-structural proteins (NSPs) (NSP7, NSP8, NSP9, NSP12, and NSP13) were screened to identify potential human leukocyte antigen (HLA) binding peptides. These peptides showed robust viral antigenicity, immunogenicity, and a marked interaction with HLA alleles. Interestingly, several peptides showed affinity by HLA class I (HLA-I) alleles that commonly activates to natural killer (NK) cells. Notably, HLA biding peptides are conserved among SARS-CoV-2, severe acute respiratory syndrome coronavirus (SARS-CoV), and Middle Eastern respiratory syndrome coronavirus (MERS-CoV). Interestingly, HLA-I and HLA class II (HLA-II) binding peptides induced humoral and cell-mediated responses after in silico vaccination. These results may open further in vitro and in vivo investigations to develop novel therapeutic strategies against coronaviral infections." @default.
• W3048520309 created "2020-08-18" @default.
• W3048520309 creator A5052291650 @default.
• W3048520309 date "2020-10-01" @default.
• W3048520309 modified "2023-10-16" @default.
• W3048520309 title "Conserved HLA binding peptides from five non-structural proteins of SARS-CoV-2—An in silico glance" @default.
• W3048520309 cites W1981108131 @default.
• W3048520309 cites W2014274241 @default.
• W3048520309 cites W2029667189 @default.
• W3048520309 cites W2035240910 @default.
• W3048520309 cites W2052221307 @default.
• W3048520309 cites W2097602001 @default.
• W3048520309 cites W2102367710 @default.
• W3048520309 cites W2127635589 @default.
• W3048520309 cites W2127814614 @default.
• W3048520309 cites W2138781831 @default.
• W3048520309 cites W2143397050 @default.
• W3048520309 cites W2151932306 @default.
• W3048520309 cites W2512372054 @default.
• W3048520309 cites W2572080171 @default.
• W3048520309 cites W2755626561 @default.
• W3048520309 cites W2922503279 @default.
• W3048520309 cites W2946946191 @default.
• W3048520309 cites W2953065444 @default.
• W3048520309 cites W3004318991 @default.
• W3048520309 cites W3005011674 @default.
• W3048520309 cites W3007407747 @default.
• W3048520309 cites W3007974386 @default.
• W3048520309 cites W3011488280 @default.
• W3048520309 cites W3013334176 @default.
• W3048520309 cites W3013853564 @default.
• W3048520309 cites W3022325117 @default.
• W3048520309 cites W3026051701 @default.
• W3048520309 cites W3027003041 @default.
• W3048520309 cites W3034131048 @default.
• W3048520309 doi "https://doi.org/10.1016/j.humimm.2020.08.001" @default.
• W3048520309 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7425717" @default.
• W3048520309 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32888767" @default.
• W3048520309 hasPublicationYear "2020" @default.
• W3048520309 type Work @default.
• W3048520309 sameAs 3048520309 @default.
• W3048520309 citedByCount "5" @default.
• W3048520309 countsByYear W30485203092021 @default.
• W3048520309 countsByYear W30485203092022 @default.
• W3048520309 crossrefType "journal-article" @default.
• W3048520309 hasAuthorship W3048520309A5052291650 @default.
• W3048520309 hasBestOaLocation W30485203091 @default.
• W3048520309 hasConcept C104317684 @default.
• W3048520309 hasConcept C142724271 @default.
• W3048520309 hasConcept C147483822 @default.
• W3048520309 hasConcept C159047783 @default.
• W3048520309 hasConcept C188280979 @default.
• W3048520309 hasConcept C195616568 @default.
• W3048520309 hasConcept C203014093 @default.
• W3048520309 hasConcept C2775905019 @default.
• W3048520309 hasConcept C2776525042 @default.
• W3048520309 hasConcept C2777648638 @default.
• W3048520309 hasConcept C2779026604 @default.
• W3048520309 hasConcept C2779134260 @default.
• W3048520309 hasConcept C2780868878 @default.
• W3048520309 hasConcept C3008058167 @default.
• W3048520309 hasConcept C524204448 @default.
• W3048520309 hasConcept C54355233 @default.
• W3048520309 hasConcept C71924100 @default.
• W3048520309 hasConcept C86803240 @default.
• W3048520309 hasConcept C8891405 @default.
• W3048520309 hasConceptScore W3048520309C104317684 @default.
• W3048520309 hasConceptScore W3048520309C142724271 @default.
• W3048520309 hasConceptScore W3048520309C147483822 @default.
• W3048520309 hasConceptScore W3048520309C159047783 @default.
• W3048520309 hasConceptScore W3048520309C188280979 @default.
• W3048520309 hasConceptScore W3048520309C195616568 @default.
• W3048520309 hasConceptScore W3048520309C203014093 @default.
• W3048520309 hasConceptScore W3048520309C2775905019 @default.
• W3048520309 hasConceptScore W3048520309C2776525042 @default.
• W3048520309 hasConceptScore W3048520309C2777648638 @default.
• W3048520309 hasConceptScore W3048520309C2779026604 @default.
• W3048520309 hasConceptScore W3048520309C2779134260 @default.
• W3048520309 hasConceptScore W3048520309C2780868878 @default.
• W3048520309 hasConceptScore W3048520309C3008058167 @default.
• W3048520309 hasConceptScore W3048520309C524204448 @default.
• W3048520309 hasConceptScore W3048520309C54355233 @default.
• W3048520309 hasConceptScore W3048520309C71924100 @default.
• W3048520309 hasConceptScore W3048520309C86803240 @default.
• W3048520309 hasConceptScore W3048520309C8891405 @default.
• W3048520309 hasIssue "10-11" @default.
• W3048520309 hasLocation W30485203091 @default.
• W3048520309 hasLocation W30485203092 @default.
• W3048520309 hasOpenAccess W3048520309 @default.
• W3048520309 hasPrimaryLocation W30485203091 @default.
• W3048520309 hasRelatedWork W1980021022 @default.
• W3048520309 hasRelatedWork W2004255297 @default.
• W3048520309 hasRelatedWork W2078042295 @default.
• W3048520309 hasRelatedWork W2115812853 @default.
• W3048520309 hasRelatedWork W2367852944 @default.
• W3048520309 hasRelatedWork W2399733012 @default.
• W3048520309 hasRelatedWork W2437539027 @default.
• W3048520309 hasRelatedWork W2469766812 @default.

• next