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- W3048529443 endingPage "5747" @default.
- W3048529443 startingPage "5747" @default.
- W3048529443 abstract "In hematological malignancies, leukemias or myelomas, malignant cells present bone marrow (BM) homing, in which the niche contributes to tumor development and drug resistance. BM architecture, cellular and molecular composition and interactions define differential microenvironments that govern cell fate under physiological and pathological conditions and serve as a reference for the native biological landscape to be replicated in engineered platforms attempting to reproduce blood cancer behavior. This review summarizes the different models used to efficiently reproduce certain aspects of BM in vitro; however, they still lack the complexity of this tissue, which is relevant for fundamental aspects such as drug resistance development in multiple myeloma. Extracellular matrix composition, material topography, vascularization, cellular composition or stemness vs. differentiation balance are discussed as variables that could be rationally defined in tissue engineering approaches for achieving more relevant in vitro models. Fully humanized platforms closely resembling natural interactions still remain challenging and the question of to what extent accurate tissue complexity reproduction is essential to reliably predict drug responses is controversial. However, the contributions of these approaches to the fundamental knowledge of non-solid tumor biology, its regulation by niches, and the advance of personalized medicine are unquestionable." @default.
- W3048529443 created "2020-08-18" @default.
- W3048529443 creator A5044457699 @default.
- W3048529443 creator A5052609345 @default.
- W3048529443 creator A5083680222 @default.
- W3048529443 date "2020-08-11" @default.
- W3048529443 modified "2023-10-14" @default.
- W3048529443 title "In Vitro Modeling of Non-Solid Tumors: How Far Can Tissue Engineering Go?" @default.
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