Matches in SemOpenAlex for { <https://semopenalex.org/work/W3048541276> ?p ?o ?g. }
- W3048541276 endingPage "200" @default.
- W3048541276 startingPage "188" @default.
- W3048541276 abstract "Hepatocellular carcinoma (HCC) is the most common primary malignant tumor of the liver. Tumor-infiltrating lymphocytes (TILs) are a class of cells that form the tumor microenvironment and thus have an effect on carcinogenesis. The aim of this study was to investigate the immunohistochemical expression of CD8, CD4, cytotoxic T lymphocyte-associated protein-4 (CTLA-4), and granzyme B in HCC and their correlation with clinicopathologic parameters and prognosis. This study was carried out on 112 cases of HCC. High percentage of CD8+ TILs was associated with large tumors and adjacent noncirrhotic liver. High percentage of CD4+ TILs and high CD4 to CD8 ratio were associated with nonviral etiology, low alpha fetoprotein, and direct acting antiviral treatment. High percentage of CTLA-4-positive TILs tended to be associated with high-grade HCC, while a high percentage of CTLA-4 in tumor cells was associated with multiple lesions and low tumor grade. High percentage of granzyme B+ TILs was associated with low grade, early stage, and absence of tumor recurrence. High CD4 percentage and high CD4/CD8 ratio affected patients' overall survival. There is a dynamic interaction between the different subsets of lymphocytes in the environment of HCC manifested by coparallel expression of CD4 and CD8 augmenting the expression of CTLA-4, and only CD8 augments the expression of granzyme B. This opens the gate for the beneficial role of immunotherapy in the management of HCC, reducing recurrence and improving survival." @default.
- W3048541276 created "2020-08-18" @default.
- W3048541276 creator A5019235222 @default.
- W3048541276 creator A5026401143 @default.
- W3048541276 creator A5026436379 @default.
- W3048541276 creator A5070134487 @default.
- W3048541276 creator A5073191619 @default.
- W3048541276 date "2020-08-04" @default.
- W3048541276 modified "2023-09-29" @default.
- W3048541276 title "The Profile and Role of Tumor-infiltrating Lymphocytes in Hepatocellular Carcinoma" @default.
- W3048541276 cites W1445550912 @default.
- W3048541276 cites W1567148978 @default.
- W3048541276 cites W1964923494 @default.
- W3048541276 cites W1968929036 @default.
- W3048541276 cites W1982062359 @default.
- W3048541276 cites W1984650310 @default.
- W3048541276 cites W1986372945 @default.
- W3048541276 cites W1992443647 @default.
- W3048541276 cites W1993851289 @default.
- W3048541276 cites W2002202749 @default.
- W3048541276 cites W2008062915 @default.
- W3048541276 cites W2016263719 @default.
- W3048541276 cites W2037607803 @default.
- W3048541276 cites W2044495921 @default.
- W3048541276 cites W2046853205 @default.
- W3048541276 cites W2047457058 @default.
- W3048541276 cites W2058016006 @default.
- W3048541276 cites W2060123467 @default.
- W3048541276 cites W2060343419 @default.
- W3048541276 cites W2082146590 @default.
- W3048541276 cites W2090629948 @default.
- W3048541276 cites W2091567258 @default.
- W3048541276 cites W2092413609 @default.
- W3048541276 cites W2102754583 @default.
- W3048541276 cites W2122656254 @default.
- W3048541276 cites W2125054954 @default.
- W3048541276 cites W2126481441 @default.
- W3048541276 cites W2127686099 @default.
- W3048541276 cites W2130121394 @default.
- W3048541276 cites W2132561915 @default.
- W3048541276 cites W2141269240 @default.
- W3048541276 cites W2153873453 @default.
- W3048541276 cites W2156740651 @default.
- W3048541276 cites W2162667703 @default.
- W3048541276 cites W2171464642 @default.
- W3048541276 cites W2289068089 @default.
- W3048541276 cites W2316755250 @default.
- W3048541276 cites W2335913920 @default.
- W3048541276 cites W2418942707 @default.
- W3048541276 cites W2508920903 @default.
- W3048541276 cites W2554954878 @default.
- W3048541276 cites W2558074211 @default.
- W3048541276 cites W2559758502 @default.
- W3048541276 cites W2588082084 @default.
- W3048541276 cites W2592906740 @default.
- W3048541276 cites W2593802464 @default.
- W3048541276 cites W2613589727 @default.
- W3048541276 cites W2637297003 @default.
- W3048541276 cites W2744685612 @default.
- W3048541276 cites W2765375430 @default.
- W3048541276 cites W2780134541 @default.
- W3048541276 cites W2795482308 @default.
- W3048541276 cites W2896852914 @default.
- W3048541276 cites W2899241249 @default.
- W3048541276 cites W2904905250 @default.
- W3048541276 cites W2911188335 @default.
- W3048541276 cites W2913384788 @default.
- W3048541276 cites W2937568516 @default.
- W3048541276 doi "https://doi.org/10.1097/pai.0000000000000865" @default.
- W3048541276 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32769442" @default.
- W3048541276 hasPublicationYear "2020" @default.
- W3048541276 type Work @default.
- W3048541276 sameAs 3048541276 @default.
- W3048541276 citedByCount "3" @default.
- W3048541276 countsByYear W30485412762022 @default.
- W3048541276 crossrefType "journal-article" @default.
- W3048541276 hasAuthorship W3048541276A5019235222 @default.
- W3048541276 hasAuthorship W3048541276A5026401143 @default.
- W3048541276 hasAuthorship W3048541276A5026436379 @default.
- W3048541276 hasAuthorship W3048541276A5070134487 @default.
- W3048541276 hasAuthorship W3048541276A5073191619 @default.
- W3048541276 hasConcept C143998085 @default.
- W3048541276 hasConcept C154317977 @default.
- W3048541276 hasConcept C167672396 @default.
- W3048541276 hasConcept C183193105 @default.
- W3048541276 hasConcept C202751555 @default.
- W3048541276 hasConcept C203014093 @default.
- W3048541276 hasConcept C204232928 @default.
- W3048541276 hasConcept C2776062744 @default.
- W3048541276 hasConcept C2776107976 @default.
- W3048541276 hasConcept C2777701055 @default.
- W3048541276 hasConcept C2777761686 @default.
- W3048541276 hasConcept C2778019345 @default.
- W3048541276 hasConcept C2778326572 @default.
- W3048541276 hasConcept C2780380082 @default.
- W3048541276 hasConcept C502942594 @default.
- W3048541276 hasConcept C55493867 @default.
- W3048541276 hasConcept C71924100 @default.