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- W3048541630 endingPage "601" @default.
- W3048541630 startingPage "591" @default.
- W3048541630 abstract "Spinal cord injury (SCI) is a debilitating neurologic condition with tremendous socioeconomic impact on affected individuals and the health care system. The treatment of SCI principally includes surgical treatment and marginal pharmacologic and rehabilitation therapies targeting secondary events with minor clinical improvements. This unsuccessful result mainly reflects the complexity of SCI pathophysiology and the diverse biochemical and physiologic changes that occur in the injured spinal cord. Once the nervous system is injured, cascades of cellular and molecular events are triggered at varying times. Although the cascade of tissue reactions and cell injury develops over a period of days or weeks, the most extensive cell death in SCI occurs within hours of trauma. This situation suggests that early intervention is likely to be the most promising approach to rescue the cord from further and irreversible cell damage. Over the past decades, a wealth of research has been conducted in preclinical and clinical studies with the hope to find new therapeutic strategies. Researchers have identified several targets for the development of potential therapeutic interventions (e.g., neuroprotection, replacement of cells lost, removal of inhibitory molecules, regeneration, and rehabilitation strategies to induce neuroplasticity). Most of these treatments have passed preclinical and initial clinical evaluations but have failed to be strongly conclusive in the clinical setting. This narrative review provides an update of the many therapeutic interventions after SCI, with an emphasis on the underlying pathophysiologic mechanisms." @default.
- W3048541630 created "2020-08-18" @default.
- W3048541630 creator A5013916661 @default.
- W3048541630 creator A5061049828 @default.
- W3048541630 creator A5088652182 @default.
- W3048541630 date "2020-08-01" @default.
- W3048541630 modified "2023-10-16" @default.
- W3048541630 title "Emerging Therapeutic Strategies for Traumatic Spinal Cord Injury" @default.
- W3048541630 cites W151008818 @default.
- W3048541630 cites W1516460285 @default.
- W3048541630 cites W1540844020 @default.
- W3048541630 cites W1543041372 @default.
- W3048541630 cites W1590729586 @default.
- W3048541630 cites W1597666961 @default.
- W3048541630 cites W1929574792 @default.
- W3048541630 cites W1966197218 @default.
- W3048541630 cites W1970024238 @default.
- W3048541630 cites W1971541966 @default.
- W3048541630 cites W1971708543 @default.
- W3048541630 cites W1977963386 @default.
- W3048541630 cites W1980373866 @default.
- W3048541630 cites W1981728019 @default.
- W3048541630 cites W1986968824 @default.
- W3048541630 cites W1989493703 @default.
- W3048541630 cites W1992656998 @default.
- W3048541630 cites W1997507612 @default.
- W3048541630 cites W2003453345 @default.
- W3048541630 cites W2004981478 @default.
- W3048541630 cites W2009204676 @default.
- W3048541630 cites W2011861117 @default.
- W3048541630 cites W2014263842 @default.
- W3048541630 cites W2014884007 @default.
- W3048541630 cites W2017559797 @default.
- W3048541630 cites W2018909644 @default.
- W3048541630 cites W2020122922 @default.
- W3048541630 cites W2021318239 @default.
- W3048541630 cites W2025416757 @default.
- W3048541630 cites W2027251820 @default.
- W3048541630 cites W2029497518 @default.
- W3048541630 cites W2029845974 @default.
- W3048541630 cites W2030010673 @default.
- W3048541630 cites W2033869466 @default.
- W3048541630 cites W2034942869 @default.
- W3048541630 cites W2034987918 @default.
- W3048541630 cites W2035120744 @default.
- W3048541630 cites W2036500329 @default.
- W3048541630 cites W2036717742 @default.
- W3048541630 cites W2036805729 @default.
- W3048541630 cites W2040489646 @default.
- W3048541630 cites W2040871722 @default.
- W3048541630 cites W2045300453 @default.
- W3048541630 cites W2049958331 @default.
- W3048541630 cites W2054118527 @default.
- W3048541630 cites W2059486167 @default.
- W3048541630 cites W2061198179 @default.
- W3048541630 cites W2063243573 @default.
- W3048541630 cites W2067157950 @default.
- W3048541630 cites W2070675281 @default.
- W3048541630 cites W2074834108 @default.
- W3048541630 cites W2078558875 @default.
- W3048541630 cites W2082817484 @default.
- W3048541630 cites W2086129284 @default.
- W3048541630 cites W2090412310 @default.
- W3048541630 cites W2093078810 @default.
- W3048541630 cites W2095110036 @default.
- W3048541630 cites W2098678041 @default.
- W3048541630 cites W2099557967 @default.
- W3048541630 cites W2100115551 @default.
- W3048541630 cites W2103161450 @default.
- W3048541630 cites W2104105197 @default.
- W3048541630 cites W2109430370 @default.
- W3048541630 cites W2109723592 @default.
- W3048541630 cites W2122041373 @default.
- W3048541630 cites W2125928168 @default.
- W3048541630 cites W2135112037 @default.
- W3048541630 cites W2142631525 @default.
- W3048541630 cites W2162975212 @default.
- W3048541630 cites W2169479856 @default.
- W3048541630 cites W2234564597 @default.
- W3048541630 cites W2317259597 @default.
- W3048541630 cites W2319060732 @default.
- W3048541630 cites W2410692873 @default.
- W3048541630 cites W2412510251 @default.
- W3048541630 cites W2413947359 @default.
- W3048541630 cites W2416339173 @default.
- W3048541630 cites W2427030016 @default.
- W3048541630 cites W2591179684 @default.
- W3048541630 cites W2604538648 @default.
- W3048541630 cites W2608611322 @default.
- W3048541630 cites W2618077382 @default.
- W3048541630 cites W2620759028 @default.
- W3048541630 cites W2752227846 @default.
- W3048541630 cites W2776984969 @default.
- W3048541630 cites W2783824491 @default.
- W3048541630 cites W2785453957 @default.
- W3048541630 cites W2785525330 @default.
- W3048541630 cites W2789879816 @default.
- W3048541630 cites W2895913344 @default.