FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3048543001> ?p ?o ?g. }

• W3048543001 endingPage "3753" @default.
• W3048543001 startingPage "3742" @default.
• W3048543001 abstract "Abstract Concomitant deregulation of MYC and BCL2 comprises clinically significant, yet poorly characterized biological high-risk feature in diffuse large B-cell lymphoma (DLBCL). To interrogate these lymphomas, we analyzed translocations and protein expression of BCL2, BCL6, and MYC; correlated the findings with comprehensive mutational, transcriptomic, and clinical data in 181 patients with primary DLBCL; and validated the key findings in independent data sets. Structural variations of BCL2 were subtype-specific and specifically increased BCL2 expression. Molecular dissection of MYC deregulation revealed associations with other lymphoma drivers, including loss of TP53, and distinctive gene expression profiles. Double protein expression (DPE) arose from heterogeneous molecular backgrounds that exhibited subtype-dependent patterns. In the germinal center B-cell (GCB) DLBCL, concurrent alterations of MYC and BCL2 loci gave rise to the majority of DPE DLBCLs, whereas among the activated B-cell (ABC) DLBCLs, concurrent alterations were infrequent. Clinically, DPE DLBCL defined a prognostic entity, which was independent of the International Prognostic Index (IPI) and cell of origin, and together with the loss of TP53 had a synergistic dismal impact on survival. In the DPE DLBCL, the loss of TP53 was associated with a chemorefractory disease, whereas among the other DLBCLs, no correlation with survival was seen. Importantly, BCL6 translocations identified non-GCB lymphomas with favorable BN2/C1-like survival independent of IPI and concurrent DPE status. Taken together, our findings define molecular characteristics of the DPE in DLBCL, and recognize clinically feasible predictors of outcome. Given the emerging taxonomical significance of BCL2, BCL6, MYC, and TP53, our findings provide further depth and validation to the genomic classification of DLBCL." @default.
• W3048543001 created "2020-08-18" @default.
• W3048543001 creator A5000211575 @default.
• W3048543001 creator A5013263576 @default.
• W3048543001 creator A5040964007 @default.
• W3048543001 creator A5051888634 @default.
• W3048543001 creator A5055183115 @default.
• W3048543001 creator A5069864713 @default.
• W3048543001 date "2020-08-11" @default.
• W3048543001 modified "2023-10-17" @default.
• W3048543001 title "Molecular background delineates outcome of double protein expressor diffuse large B-cell lymphoma" @default.
• W3048543001 cites W1547608553 @default.
• W3048543001 cites W1862607355 @default.
• W3048543001 cites W1979816280 @default.
• W3048543001 cites W1982357474 @default.
• W3048543001 cites W2010117150 @default.
• W3048543001 cites W2022013393 @default.
• W3048543001 cites W2029473952 @default.
• W3048543001 cites W2032972450 @default.
• W3048543001 cites W2089298737 @default.
• W3048543001 cites W2090026828 @default.
• W3048543001 cites W2096596684 @default.
• W3048543001 cites W2125640515 @default.
• W3048543001 cites W2147246240 @default.
• W3048543001 cites W2153944703 @default.
• W3048543001 cites W2154191201 @default.
• W3048543001 cites W2158267770 @default.
• W3048543001 cites W2159862107 @default.
• W3048543001 cites W2279127916 @default.
• W3048543001 cites W2310716991 @default.
• W3048543001 cites W2598696175 @default.
• W3048543001 cites W2614435853 @default.
• W3048543001 cites W2773804840 @default.
• W3048543001 cites W2788380546 @default.
• W3048543001 cites W2797584152 @default.
• W3048543001 cites W2801763724 @default.
• W3048543001 cites W2809201980 @default.
• W3048543001 cites W2896704395 @default.
• W3048543001 cites W2902375153 @default.
• W3048543001 cites W2903062212 @default.
• W3048543001 cites W2903278833 @default.
• W3048543001 cites W2922237910 @default.
• W3048543001 cites W2927138762 @default.
• W3048543001 cites W2972566401 @default.
• W3048543001 cites W2973607898 @default.
• W3048543001 cites W2984927918 @default.
• W3048543001 cites W3012464003 @default.
• W3048543001 cites W3016044607 @default.
• W3048543001 cites W41459023 @default.
• W3048543001 doi "https://doi.org/10.1182/bloodadvances.2020001727" @default.
• W3048543001 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7422114" @default.
• W3048543001 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32780847" @default.
• W3048543001 hasPublicationYear "2020" @default.
• W3048543001 type Work @default.
• W3048543001 sameAs 3048543001 @default.
• W3048543001 citedByCount "19" @default.
• W3048543001 countsByYear W30485430012020 @default.
• W3048543001 countsByYear W30485430012021 @default.
• W3048543001 countsByYear W30485430012022 @default.
• W3048543001 countsByYear W30485430012023 @default.
• W3048543001 crossrefType "journal-article" @default.
• W3048543001 hasAuthorship W3048543001A5000211575 @default.
• W3048543001 hasAuthorship W3048543001A5013263576 @default.
• W3048543001 hasAuthorship W3048543001A5040964007 @default.
• W3048543001 hasAuthorship W3048543001A5051888634 @default.
• W3048543001 hasAuthorship W3048543001A5055183115 @default.
• W3048543001 hasAuthorship W3048543001A5069864713 @default.
• W3048543001 hasBestOaLocation W30485430011 @default.
• W3048543001 hasConcept C104317684 @default.
• W3048543001 hasConcept C126322002 @default.
• W3048543001 hasConcept C138626823 @default.
• W3048543001 hasConcept C143998085 @default.
• W3048543001 hasConcept C159654299 @default.
• W3048543001 hasConcept C203014093 @default.
• W3048543001 hasConcept C2777537477 @default.
• W3048543001 hasConcept C2778453870 @default.
• W3048543001 hasConcept C2778476033 @default.
• W3048543001 hasConcept C2778559949 @default.
• W3048543001 hasConcept C2779338263 @default.
• W3048543001 hasConcept C502942594 @default.
• W3048543001 hasConcept C54355233 @default.
• W3048543001 hasConcept C71924100 @default.
• W3048543001 hasConcept C86803240 @default.
• W3048543001 hasConcept C96926380 @default.
• W3048543001 hasConceptScore W3048543001C104317684 @default.
• W3048543001 hasConceptScore W3048543001C126322002 @default.
• W3048543001 hasConceptScore W3048543001C138626823 @default.
• W3048543001 hasConceptScore W3048543001C143998085 @default.
• W3048543001 hasConceptScore W3048543001C159654299 @default.
• W3048543001 hasConceptScore W3048543001C203014093 @default.
• W3048543001 hasConceptScore W3048543001C2777537477 @default.
• W3048543001 hasConceptScore W3048543001C2778453870 @default.
• W3048543001 hasConceptScore W3048543001C2778476033 @default.
• W3048543001 hasConceptScore W3048543001C2778559949 @default.
• W3048543001 hasConceptScore W3048543001C2779338263 @default.
• W3048543001 hasConceptScore W3048543001C502942594 @default.
• W3048543001 hasConceptScore W3048543001C54355233 @default.
• W3048543001 hasConceptScore W3048543001C71924100 @default.

• next