Matches in SemOpenAlex for { <https://semopenalex.org/work/W3048546677> ?p ?o ?g. }
- W3048546677 abstract "Inflammatory bowel disease (IBD) is characterized by chronic relapsing inflammation in the intestine. Given their role in regulation of inflammation, long-chain n-3 polyunsaturated fatty acids (PUFAs) represent a potential supplementary therapeutic approach to current drug regimens used for IBD. Mechanistically, there is ample evidence for an anti-inflammatory and pro-resolution effect of long-chain n-3 PUFAs after they incorporate into cell membrane phospholipids. They disrupt membrane rafts and when released from the membrane suppress inflammatory signaling by activating PPAR-γ and free fatty acid receptor 4; furthermore, they shift the lipid mediator profile from pro-inflammatory eicosanoids to specialized pro-resolving mediators. The allocation of long-chain n-3 PUFAs also leads to a higher microbiome diversity in the gut, increases short-chain fatty acid-producing bacteria, and improves intestinal barrier function by sealing epithelial tight junctions. In line with these mechanistic studies, most epidemiological studies support a beneficial effect of long-chain n-3 PUFAs intake on reducing the incidence of IBD. However, the results from intervention trials on the prevention of relapse in IBD patients show no or only a marginal effect of long-chain n-3 PUFAs supplementation. In light of the current literature, international recommendations are supported that adequate diet-derived n-3 PUFAs might be beneficial in maintaining remission in IBD patients." @default.
- W3048546677 created "2020-08-18" @default.
- W3048546677 creator A5029425739 @default.
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- W3048546677 date "2020-08-26" @default.
- W3048546677 modified "2023-09-27" @default.
- W3048546677 title "Nutritional Lipids and Mucosal Inflammation" @default.
- W3048546677 cites W1167178751 @default.
- W3048546677 cites W1552747622 @default.
- W3048546677 cites W1578779604 @default.
- W3048546677 cites W1766122222 @default.
- W3048546677 cites W1954377392 @default.
- W3048546677 cites W1956939595 @default.
- W3048546677 cites W1963501193 @default.
- W3048546677 cites W1963625450 @default.
- W3048546677 cites W1963728493 @default.
- W3048546677 cites W1964574002 @default.
- W3048546677 cites W1965671899 @default.
- W3048546677 cites W1968528693 @default.
- W3048546677 cites W1974226247 @default.
- W3048546677 cites W1977111258 @default.
- W3048546677 cites W1978299374 @default.
- W3048546677 cites W1979004719 @default.
- W3048546677 cites W1980934355 @default.
- W3048546677 cites W1982714231 @default.
- W3048546677 cites W1985683101 @default.
- W3048546677 cites W1988296456 @default.
- W3048546677 cites W1995373964 @default.
- W3048546677 cites W1996078707 @default.
- W3048546677 cites W1997179064 @default.
- W3048546677 cites W2000675841 @default.
- W3048546677 cites W2009925138 @default.
- W3048546677 cites W2018447001 @default.
- W3048546677 cites W2019262921 @default.
- W3048546677 cites W2021608770 @default.
- W3048546677 cites W2025451832 @default.
- W3048546677 cites W2032206624 @default.
- W3048546677 cites W2034888385 @default.
- W3048546677 cites W2037111661 @default.
- W3048546677 cites W2043659905 @default.
- W3048546677 cites W2046997607 @default.
- W3048546677 cites W2049499648 @default.
- W3048546677 cites W2052766728 @default.
- W3048546677 cites W2053334642 @default.
- W3048546677 cites W2054093116 @default.
- W3048546677 cites W2055515746 @default.
- W3048546677 cites W2055909907 @default.
- W3048546677 cites W2057294019 @default.
- W3048546677 cites W2059332039 @default.
- W3048546677 cites W2060185417 @default.
- W3048546677 cites W2062456565 @default.
- W3048546677 cites W2062835892 @default.
- W3048546677 cites W2064355487 @default.
- W3048546677 cites W2064399682 @default.
- W3048546677 cites W2070782595 @default.
- W3048546677 cites W2070852224 @default.
- W3048546677 cites W2072186197 @default.
- W3048546677 cites W2072863782 @default.
- W3048546677 cites W2074751818 @default.
- W3048546677 cites W2076511407 @default.
- W3048546677 cites W2078078010 @default.
- W3048546677 cites W2081839805 @default.
- W3048546677 cites W2082537421 @default.
- W3048546677 cites W2084138571 @default.
- W3048546677 cites W2086043144 @default.
- W3048546677 cites W2088140671 @default.
- W3048546677 cites W2088874765 @default.
- W3048546677 cites W2090248973 @default.
- W3048546677 cites W2094826033 @default.
- W3048546677 cites W2096736123 @default.
- W3048546677 cites W2101841000 @default.
- W3048546677 cites W2104285446 @default.
- W3048546677 cites W2105058392 @default.
- W3048546677 cites W2106132036 @default.
- W3048546677 cites W2116470680 @default.
- W3048546677 cites W2119692673 @default.
- W3048546677 cites W2119921183 @default.
- W3048546677 cites W2126853519 @default.
- W3048546677 cites W2128257992 @default.
- W3048546677 cites W2128769815 @default.
- W3048546677 cites W2129086067 @default.
- W3048546677 cites W2130359297 @default.
- W3048546677 cites W2131094572 @default.
- W3048546677 cites W2132288432 @default.
- W3048546677 cites W2133955233 @default.
- W3048546677 cites W2139002144 @default.
- W3048546677 cites W2139086060 @default.
- W3048546677 cites W2143545673 @default.
- W3048546677 cites W2146883005 @default.
- W3048546677 cites W2148536296 @default.
- W3048546677 cites W2152870115 @default.
- W3048546677 cites W2152995125 @default.
- W3048546677 cites W2157393124 @default.
- W3048546677 cites W2158603948 @default.