FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3048551457> ?p ?o ?g. }

• W3048551457 endingPage "1177" @default.
• W3048551457 startingPage "1166" @default.
• W3048551457 abstract "Abstract Pluripotent stem cells (PSCs) are attractive regenerative therapy tools for skeletal tissues. However, a deep understanding of skeletal development is required in order to model this development with PSCs, and for the application of PSCs in clinical settings. Skeletal tissues originate from three types of cell populations: the paraxial mesoderm, lateral plate mesoderm, and neural crest. The paraxial mesoderm gives rise to the sclerotome mainly through somitogenesis. In this process, key developmental processes, including initiation of the segmentation clock, formation of the determination front, and the mesenchymal–epithelial transition, are sequentially coordinated. The sclerotome further forms vertebral columns and contributes to various other tissues, such as tendons, vessels (including the dorsal aorta), and even meninges. To understand the molecular mechanisms underlying these developmental processes, extensive studies have been conducted. These studies have demonstrated that a gradient of activities involving multiple signaling pathways specify the embryonic axis and induce cell-type-specific master transcription factors in a spatiotemporal manner. Moreover, applying the knowledge of mesoderm development, researchers have attempted to recapitulate the in vivo development processes in in vitro settings, using mouse and human PSCs. In this review, we summarize the state-of-the-art understanding of mesoderm development and in vitro modeling of mesoderm development using PSCs. We also discuss future perspectives on the use of PSCs to generate skeletal tissues for basic research and clinical applications." @default.
• W3048551457 created "2020-08-18" @default.
• W3048551457 creator A5002017446 @default.
• W3048551457 creator A5028980737 @default.
• W3048551457 creator A5047263663 @default.
• W3048551457 creator A5048462960 @default.
• W3048551457 date "2020-08-01" @default.
• W3048551457 modified "2023-10-15" @default.
• W3048551457 title "Understanding paraxial mesoderm development and sclerotome specification for skeletal repair" @default.
• W3048551457 cites W1461755553 @default.
• W3048551457 cites W1635421292 @default.
• W3048551457 cites W1785552397 @default.
• W3048551457 cites W1834281701 @default.
• W3048551457 cites W1896587447 @default.
• W3048551457 cites W1932544557 @default.
• W3048551457 cites W1953958400 @default.
• W3048551457 cites W1956061573 @default.
• W3048551457 cites W1967087643 @default.
• W3048551457 cites W1969054485 @default.
• W3048551457 cites W1973160382 @default.
• W3048551457 cites W1979215517 @default.
• W3048551457 cites W1989704711 @default.
• W3048551457 cites W1990665236 @default.
• W3048551457 cites W1997278755 @default.
• W3048551457 cites W1997638149 @default.
• W3048551457 cites W1997640596 @default.
• W3048551457 cites W1999733778 @default.
• W3048551457 cites W2000543092 @default.
• W3048551457 cites W2000898869 @default.
• W3048551457 cites W2002178143 @default.
• W3048551457 cites W2011237068 @default.
• W3048551457 cites W2012986637 @default.
• W3048551457 cites W2014179934 @default.
• W3048551457 cites W2014971526 @default.
• W3048551457 cites W2015890999 @default.
• W3048551457 cites W2016633058 @default.
• W3048551457 cites W2017807559 @default.
• W3048551457 cites W2019767502 @default.
• W3048551457 cites W2020458486 @default.
• W3048551457 cites W2020597782 @default.
• W3048551457 cites W2021580816 @default.
• W3048551457 cites W2023403227 @default.
• W3048551457 cites W2025182546 @default.
• W3048551457 cites W2025776507 @default.
• W3048551457 cites W2026211608 @default.
• W3048551457 cites W2027607261 @default.
• W3048551457 cites W2028674158 @default.
• W3048551457 cites W2030998129 @default.
• W3048551457 cites W2032323519 @default.
• W3048551457 cites W2033904138 @default.
• W3048551457 cites W2034609545 @default.
• W3048551457 cites W2036519060 @default.
• W3048551457 cites W2037012024 @default.
• W3048551457 cites W2042808466 @default.
• W3048551457 cites W2049423499 @default.
• W3048551457 cites W2053702504 @default.
• W3048551457 cites W2059614045 @default.
• W3048551457 cites W2061948959 @default.
• W3048551457 cites W2066444776 @default.
• W3048551457 cites W2067226341 @default.
• W3048551457 cites W2068329746 @default.
• W3048551457 cites W2072219472 @default.
• W3048551457 cites W2074314696 @default.
• W3048551457 cites W2080924352 @default.
• W3048551457 cites W2083774566 @default.
• W3048551457 cites W2085205835 @default.
• W3048551457 cites W2087206546 @default.
• W3048551457 cites W2088043742 @default.
• W3048551457 cites W2090255071 @default.
• W3048551457 cites W2092953036 @default.
• W3048551457 cites W2097706279 @default.
• W3048551457 cites W2103412450 @default.
• W3048551457 cites W2104235481 @default.
• W3048551457 cites W2105828453 @default.
• W3048551457 cites W2110035324 @default.
• W3048551457 cites W2110815987 @default.
• W3048551457 cites W2113198452 @default.
• W3048551457 cites W2120125727 @default.
• W3048551457 cites W2125551434 @default.
• W3048551457 cites W2130646768 @default.
• W3048551457 cites W2135447402 @default.
• W3048551457 cites W2146639522 @default.
• W3048551457 cites W2153214810 @default.
• W3048551457 cites W2154905243 @default.
• W3048551457 cites W2157333690 @default.
• W3048551457 cites W2158600078 @default.
• W3048551457 cites W2160775930 @default.
• W3048551457 cites W2167489986 @default.
• W3048551457 cites W2168298530 @default.
• W3048551457 cites W2171906614 @default.
• W3048551457 cites W2405685946 @default.
• W3048551457 cites W2461230718 @default.
• W3048551457 cites W2531776969 @default.
• W3048551457 cites W2587551702 @default.
• W3048551457 cites W2601350462 @default.
• W3048551457 cites W2613064536 @default.
• W3048551457 cites W2616303227 @default.
• W3048551457 cites W2767871975 @default.

• next