FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3048552615> ?p ?o ?g. }

• W3048552615 endingPage "781" @default.
• W3048552615 startingPage "773" @default.
• W3048552615 abstract "Abstract Busulfan is given in the conditioning regimens preceding hematopoietic stem cell transplantation (HSCT), and plasma levels can be monitored. A targeted, individualized systemic exposure (SE) dose can be achieved by calculating the area under the plasma concentration versus time curve (AUC). The objective of this study was to determine a cutoff value for safety for the AUC for busulfan plasma levels in patients undergoing HSCT. A total of 149 consecutive HSCT patients were studied. After an oral test dose of busulfan, we set target doses of 4000, 5000, or 6000 µMol⸱min/day, and analyzed the AUC of oral or intravenous Bu. These patients were compared with 53 historical control subjects who had received myeloablative conditioning regimen without busulfan pharmacokinetic monitoring. Using a test dose and the administration route had no impact on the sinusoidal obstructive syndrome (SOS) incidence, transplant‐related mortality or 1‐year overall survival. However, patients receiving busulfan at doses set up at AUC > 5000 had an increased risk to develop SOS after HSCT (hazard ratio 3.39, p = 0.034, 95% CI 1.09–10.52). Adjusting the busulfan dose according to SE levels target dose during conditioning is associated with lower rates of oral severe mucositis and SOS. A cutoff of 5000 µMol⸱min is safe and does not impair survival." @default.
• W3048552615 created "2020-08-18" @default.
• W3048552615 creator A5003177185 @default.
• W3048552615 creator A5004417292 @default.
• W3048552615 creator A5022947439 @default.
• W3048552615 creator A5034264716 @default.
• W3048552615 creator A5035480348 @default.
• W3048552615 creator A5037905694 @default.
• W3048552615 creator A5042125969 @default.
• W3048552615 creator A5051260187 @default.
• W3048552615 creator A5055586226 @default.
• W3048552615 creator A5056794641 @default.
• W3048552615 creator A5058077332 @default.
• W3048552615 creator A5079545506 @default.
• W3048552615 creator A5090912397 @default.
• W3048552615 date "2020-09-28" @default.
• W3048552615 modified "2023-10-03" @default.
• W3048552615 title "Targeted‐dose of busulfan: Higher risk of sinusoidal obstructive syndrome observed with systemic exposure dose above 5000 µMol⸱min. A historically controlled clinical trial" @default.
• W3048552615 cites W1558195332 @default.
• W3048552615 cites W1966163786 @default.
• W3048552615 cites W1973519172 @default.
• W3048552615 cites W1974632374 @default.
• W3048552615 cites W1993803504 @default.
• W3048552615 cites W1999322421 @default.
• W3048552615 cites W2007501893 @default.
• W3048552615 cites W2017821630 @default.
• W3048552615 cites W2018956546 @default.
• W3048552615 cites W2027025310 @default.
• W3048552615 cites W2032332829 @default.
• W3048552615 cites W2035143393 @default.
• W3048552615 cites W2038424578 @default.
• W3048552615 cites W2046147885 @default.
• W3048552615 cites W2062871466 @default.
• W3048552615 cites W2073140442 @default.
• W3048552615 cites W2075030023 @default.
• W3048552615 cites W2090989822 @default.
• W3048552615 cites W2093607596 @default.
• W3048552615 cites W2108637334 @default.
• W3048552615 cites W2116478257 @default.
• W3048552615 cites W2121599032 @default.
• W3048552615 cites W2122712927 @default.
• W3048552615 cites W2125312770 @default.
• W3048552615 cites W2130123826 @default.
• W3048552615 cites W2136016420 @default.
• W3048552615 cites W2276362528 @default.
• W3048552615 cites W2323284931 @default.
• W3048552615 cites W2559892488 @default.
• W3048552615 cites W2604031493 @default.
• W3048552615 cites W2946336199 @default.
• W3048552615 cites W4230560083 @default.
• W3048552615 cites W1974637407 @default.
• W3048552615 doi "https://doi.org/10.1002/hon.2789" @default.
• W3048552615 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32779746" @default.
• W3048552615 hasPublicationYear "2020" @default.
• W3048552615 type Work @default.
• W3048552615 sameAs 3048552615 @default.
• W3048552615 citedByCount "6" @default.
• W3048552615 countsByYear W30485526152021 @default.
• W3048552615 countsByYear W30485526152022 @default.
• W3048552615 countsByYear W30485526152023 @default.
• W3048552615 crossrefType "journal-article" @default.
• W3048552615 hasAuthorship W3048552615A5003177185 @default.
• W3048552615 hasAuthorship W3048552615A5004417292 @default.
• W3048552615 hasAuthorship W3048552615A5022947439 @default.
• W3048552615 hasAuthorship W3048552615A5034264716 @default.
• W3048552615 hasAuthorship W3048552615A5035480348 @default.
• W3048552615 hasAuthorship W3048552615A5037905694 @default.
• W3048552615 hasAuthorship W3048552615A5042125969 @default.
• W3048552615 hasAuthorship W3048552615A5051260187 @default.
• W3048552615 hasAuthorship W3048552615A5055586226 @default.
• W3048552615 hasAuthorship W3048552615A5056794641 @default.
• W3048552615 hasAuthorship W3048552615A5058077332 @default.
• W3048552615 hasAuthorship W3048552615A5079545506 @default.
• W3048552615 hasAuthorship W3048552615A5090912397 @default.
• W3048552615 hasConcept C112705442 @default.
• W3048552615 hasConcept C126322002 @default.
• W3048552615 hasConcept C126894567 @default.
• W3048552615 hasConcept C141071460 @default.
• W3048552615 hasConcept C207103383 @default.
• W3048552615 hasConcept C2777408962 @default.
• W3048552615 hasConcept C2778496288 @default.
• W3048552615 hasConcept C2780611847 @default.
• W3048552615 hasConcept C2781413609 @default.
• W3048552615 hasConcept C2911091166 @default.
• W3048552615 hasConcept C29730261 @default.
• W3048552615 hasConcept C44249647 @default.
• W3048552615 hasConcept C71924100 @default.
• W3048552615 hasConcept C76318530 @default.
• W3048552615 hasConcept C90924648 @default.
• W3048552615 hasConceptScore W3048552615C112705442 @default.
• W3048552615 hasConceptScore W3048552615C126322002 @default.
• W3048552615 hasConceptScore W3048552615C126894567 @default.
• W3048552615 hasConceptScore W3048552615C141071460 @default.
• W3048552615 hasConceptScore W3048552615C207103383 @default.
• W3048552615 hasConceptScore W3048552615C2777408962 @default.
• W3048552615 hasConceptScore W3048552615C2778496288 @default.
• W3048552615 hasConceptScore W3048552615C2780611847 @default.
• W3048552615 hasConceptScore W3048552615C2781413609 @default.

• next