Matches in SemOpenAlex for { <https://semopenalex.org/work/W3048553767> ?p ?o ?g. }
- W3048553767 abstract "In Schizosaccharomyces pombe, a general strategy for survival in response to environmental changes is sexual differentiation, which is triggered by TORC1 inactivation. However, mechanisms of TORC1 regulation in fission yeast remain poorly understood. In this study, we found that Pef1, which is an ortholog of mammalian CDK5, regulates the initiation of sexual differentiation through positive regulation of TORC1 activity. Conversely, deletion of pef1 leads to activation of autophagy and subsequent excessive TORC1 reactivation during the early phases of the nitrogen starvation response. This excessive TORC1 reactivation results in the silencing of the Ste11-Mei2 pathway and mating defects. Additionally, we found that pef1 genetically interacts with tsc1/2 in TORC1 regulation, and physically interacts with three types of cyclins, Clg1, Pas1, and Psl1. The double deletion of clg1 and pas1 promotes activation of autophagy and TORC1 during nitrogen starvation, similar to pef1Δ cells. Overall, our work suggests that Pef1-Clg1 and Pef1-Pas1 complexes regulate initiation of sexual differentiation through control of the TSC-TORC1 pathway and autophagy." @default.
- W3048553767 created "2020-08-18" @default.
- W3048553767 creator A5002589305 @default.
- W3048553767 creator A5042217051 @default.
- W3048553767 creator A5070678598 @default.
- W3048553767 creator A5072164143 @default.
- W3048553767 date "2020-01-01" @default.
- W3048553767 modified "2023-10-15" @default.
- W3048553767 title "<i>S. pombe</i> Pef1/CDK5 regulates sexual differentiation through control of the TORC1 pathway and autophagy" @default.
- W3048553767 cites W1539010571 @default.
- W3048553767 cites W180349165 @default.
- W3048553767 cites W1836114780 @default.
- W3048553767 cites W1877343178 @default.
- W3048553767 cites W1968139367 @default.
- W3048553767 cites W1971468364 @default.
- W3048553767 cites W1974507721 @default.
- W3048553767 cites W1985245436 @default.
- W3048553767 cites W1993431258 @default.
- W3048553767 cites W1996612953 @default.
- W3048553767 cites W2000539000 @default.
- W3048553767 cites W2001794548 @default.
- W3048553767 cites W2007245783 @default.
- W3048553767 cites W2015267380 @default.
- W3048553767 cites W2016833860 @default.
- W3048553767 cites W2017779665 @default.
- W3048553767 cites W2027353731 @default.
- W3048553767 cites W2029868511 @default.
- W3048553767 cites W2030920471 @default.
- W3048553767 cites W2033093913 @default.
- W3048553767 cites W2037848332 @default.
- W3048553767 cites W2042368221 @default.
- W3048553767 cites W2043831708 @default.
- W3048553767 cites W2052905844 @default.
- W3048553767 cites W2055684843 @default.
- W3048553767 cites W2058582467 @default.
- W3048553767 cites W2059765843 @default.
- W3048553767 cites W2065700634 @default.
- W3048553767 cites W2071519714 @default.
- W3048553767 cites W2075152619 @default.
- W3048553767 cites W2082673504 @default.
- W3048553767 cites W2088219073 @default.
- W3048553767 cites W2089605419 @default.
- W3048553767 cites W2094353613 @default.
- W3048553767 cites W2096065556 @default.
- W3048553767 cites W2097561128 @default.
- W3048553767 cites W2101941714 @default.
- W3048553767 cites W2103711397 @default.
- W3048553767 cites W2107620122 @default.
- W3048553767 cites W2110796584 @default.
- W3048553767 cites W2114950908 @default.
- W3048553767 cites W2116333853 @default.
- W3048553767 cites W2117994966 @default.
- W3048553767 cites W2119385226 @default.
- W3048553767 cites W2139910083 @default.
- W3048553767 cites W2144318469 @default.
- W3048553767 cites W2147544249 @default.
- W3048553767 cites W2151535829 @default.
- W3048553767 cites W2158328061 @default.
- W3048553767 cites W2194986544 @default.
- W3048553767 cites W2285630760 @default.
- W3048553767 cites W2599709405 @default.
- W3048553767 cites W2726481452 @default.
- W3048553767 cites W2742449372 @default.
- W3048553767 cites W2783900853 @default.
- W3048553767 cites W2856084368 @default.
- W3048553767 cites W2896869836 @default.
- W3048553767 cites W2906239197 @default.
- W3048553767 cites W2988108678 @default.
- W3048553767 doi "https://doi.org/10.1242/jcs.247817" @default.
- W3048553767 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34005275" @default.
- W3048553767 hasPublicationYear "2020" @default.
- W3048553767 type Work @default.
- W3048553767 sameAs 3048553767 @default.
- W3048553767 citedByCount "4" @default.
- W3048553767 countsByYear W30485537672021 @default.
- W3048553767 crossrefType "journal-article" @default.
- W3048553767 hasAuthorship W3048553767A5002589305 @default.
- W3048553767 hasAuthorship W3048553767A5042217051 @default.
- W3048553767 hasAuthorship W3048553767A5070678598 @default.
- W3048553767 hasAuthorship W3048553767A5072164143 @default.
- W3048553767 hasBestOaLocation W30485537671 @default.
- W3048553767 hasConcept C104317684 @default.
- W3048553767 hasConcept C119056186 @default.
- W3048553767 hasConcept C190283241 @default.
- W3048553767 hasConcept C203522944 @default.
- W3048553767 hasConcept C2777576037 @default.
- W3048553767 hasConcept C2779222958 @default.
- W3048553767 hasConcept C2779429346 @default.
- W3048553767 hasConcept C54355233 @default.
- W3048553767 hasConcept C63405245 @default.
- W3048553767 hasConcept C86803240 @default.
- W3048553767 hasConcept C95444343 @default.
- W3048553767 hasConceptScore W3048553767C104317684 @default.
- W3048553767 hasConceptScore W3048553767C119056186 @default.
- W3048553767 hasConceptScore W3048553767C190283241 @default.
- W3048553767 hasConceptScore W3048553767C203522944 @default.
- W3048553767 hasConceptScore W3048553767C2777576037 @default.
- W3048553767 hasConceptScore W3048553767C2779222958 @default.
- W3048553767 hasConceptScore W3048553767C2779429346 @default.
- W3048553767 hasConceptScore W3048553767C54355233 @default.