FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3048556543> ?p ?o ?g. }

• W3048556543 endingPage "92" @default.
• W3048556543 startingPage "87" @default.
• W3048556543 abstract "Squamous cell carcinomas (SqCC) of the lung often express high levels of thymidylate synthase (TS), which is associated with primary resistance to pemetrexed. We explored the efficacy of pemetrexed in a selected population of patients with lung SqCC with low TS expression.In this single-arm phase II trial, we enrolled 32 previously-treated patients with advanced lung SqCC exhibiting low immunohistochemical staining for TS (i.e., in 10% or less of tumor cells). The primary endpoint was 12-week progression-free survival (PFS) rate.Of 32 patients, eight patients (25%) had an Eastern Cooperative Oncology Group performance status of 2, and seven patients (22%) had previously received three or more lines of chemotherapy. The disease control rate from pemetrexed treatment was 30%, and no objective response was observed. The 12-week PFS rate was 24.5% (95% confidence interval [CI], 13.0 to 46.1). Median PFS was 1.3 months (95% CI, 1.3 to 2.7), and median overall survival was 11.8 months (95% CI, 8.1 to not applicable). Most of adverse events were grade 1 or 2.Pemetrexed demonstrated modest activity as a salvage chemotherapy in patients with advanced lung SqCC with low TS expression, although its toxicity was generally manageable." @default.
• W3048556543 created "2020-08-18" @default.
• W3048556543 creator A5004340711 @default.
• W3048556543 creator A5011700088 @default.
• W3048556543 creator A5019305076 @default.
• W3048556543 creator A5019571637 @default.
• W3048556543 creator A5023055777 @default.
• W3048556543 creator A5026667487 @default.
• W3048556543 creator A5055974749 @default.
• W3048556543 creator A5057493043 @default.
• W3048556543 creator A5079274190 @default.
• W3048556543 creator A5082220016 @default.
• W3048556543 date "2021-01-15" @default.
• W3048556543 modified "2023-10-14" @default.
• W3048556543 title "Phase II Study of Pemetrexed as a Salvage Chemotherapy for Thymidylate Synthase–Low Squamous Cell Lung Cancer" @default.
• W3048556543 cites W1966571450 @default.
• W3048556543 cites W1985329793 @default.
• W3048556543 cites W1998340100 @default.
• W3048556543 cites W2000456165 @default.
• W3048556543 cites W2014881369 @default.
• W3048556543 cites W2019607817 @default.
• W3048556543 cites W2040581402 @default.
• W3048556543 cites W2047986057 @default.
• W3048556543 cites W2057955518 @default.
• W3048556543 cites W2064595752 @default.
• W3048556543 cites W2077656555 @default.
• W3048556543 cites W2099725888 @default.
• W3048556543 cites W2104981110 @default.
• W3048556543 cites W2112362471 @default.
• W3048556543 cites W2112621029 @default.
• W3048556543 cites W2128542677 @default.
• W3048556543 cites W2134667653 @default.
• W3048556543 cites W2136403887 @default.
• W3048556543 cites W2136950355 @default.
• W3048556543 cites W2139939379 @default.
• W3048556543 cites W2152454229 @default.
• W3048556543 cites W2156728903 @default.
• W3048556543 cites W2229928428 @default.
• W3048556543 cites W2275877493 @default.
• W3048556543 cites W2762777471 @default.
• W3048556543 cites W2892640821 @default.
• W3048556543 cites W2910245285 @default.
• W3048556543 cites W2986790007 @default.
• W3048556543 cites W2997939984 @default.
• W3048556543 cites W4210280122 @default.
• W3048556543 doi "https://doi.org/10.4143/crt.2020.741" @default.
• W3048556543 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7812006" @default.
• W3048556543 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32810931" @default.
• W3048556543 hasPublicationYear "2021" @default.
• W3048556543 type Work @default.
• W3048556543 sameAs 3048556543 @default.
• W3048556543 citedByCount "0" @default.
• W3048556543 crossrefType "journal-article" @default.
• W3048556543 hasAuthorship W3048556543A5004340711 @default.
• W3048556543 hasAuthorship W3048556543A5011700088 @default.
• W3048556543 hasAuthorship W3048556543A5019305076 @default.
• W3048556543 hasAuthorship W3048556543A5019571637 @default.
• W3048556543 hasAuthorship W3048556543A5023055777 @default.
• W3048556543 hasAuthorship W3048556543A5026667487 @default.
• W3048556543 hasAuthorship W3048556543A5055974749 @default.
• W3048556543 hasAuthorship W3048556543A5057493043 @default.
• W3048556543 hasAuthorship W3048556543A5079274190 @default.
• W3048556543 hasAuthorship W3048556543A5082220016 @default.
• W3048556543 hasBestOaLocation W30485565431 @default.
• W3048556543 hasConcept C123321153 @default.
• W3048556543 hasConcept C126322002 @default.
• W3048556543 hasConcept C143998085 @default.
• W3048556543 hasConcept C203092338 @default.
• W3048556543 hasConcept C2776256026 @default.
• W3048556543 hasConcept C2776694085 @default.
• W3048556543 hasConcept C2777240266 @default.
• W3048556543 hasConcept C2778239845 @default.
• W3048556543 hasConcept C2780456651 @default.
• W3048556543 hasConcept C2908647359 @default.
• W3048556543 hasConcept C31760486 @default.
• W3048556543 hasConcept C535046627 @default.
• W3048556543 hasConcept C71924100 @default.
• W3048556543 hasConcept C90924648 @default.
• W3048556543 hasConcept C99454951 @default.
• W3048556543 hasConceptScore W3048556543C123321153 @default.
• W3048556543 hasConceptScore W3048556543C126322002 @default.
• W3048556543 hasConceptScore W3048556543C143998085 @default.
• W3048556543 hasConceptScore W3048556543C203092338 @default.
• W3048556543 hasConceptScore W3048556543C2776256026 @default.
• W3048556543 hasConceptScore W3048556543C2776694085 @default.
• W3048556543 hasConceptScore W3048556543C2777240266 @default.
• W3048556543 hasConceptScore W3048556543C2778239845 @default.
• W3048556543 hasConceptScore W3048556543C2780456651 @default.
• W3048556543 hasConceptScore W3048556543C2908647359 @default.
• W3048556543 hasConceptScore W3048556543C31760486 @default.
• W3048556543 hasConceptScore W3048556543C535046627 @default.
• W3048556543 hasConceptScore W3048556543C71924100 @default.
• W3048556543 hasConceptScore W3048556543C90924648 @default.
• W3048556543 hasConceptScore W3048556543C99454951 @default.
• W3048556543 hasFunder F4320322052 @default.
• W3048556543 hasIssue "1" @default.
• W3048556543 hasLocation W30485565431 @default.
• W3048556543 hasLocation W30485565432 @default.

• next