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- W3048558840 abstract "Streptococcus (S.) suis is a commensal in the upper respiratory tract of pigs, but it can also cause severe systemic diseases leading to high economic losses in the swine industry worldwide. Suilysin (SLY) is an important virulence-associated factor of S. suis and a member of the family of cholesterol-dependent cytolysins (CDC). It is assumed to contribute to the pathogenicity of S. suis by causing cell damage through lytic pore formation and by promoting bacterial adherence to cells. In the present study, we found that the amount of membrane-bound SLY and the cellular resealing capacity contribute to the susceptibility of different respiratory epithelial cells towards SLY. Moreover, well-differentiated primary porcine respiratory epithelial cells under air-liquid interface (ALI) conditions were more susceptible towards SLY induced cytotoxicity as compared to undifferentiated cells. Infection of well differentiated ALI cultures with S. suis showed that cytotoxicity induced by S. suis and bacterial adherence were dependent on the presence of SLY. These effects were enhanced or, in the absence of SLY, could even be replaced by pre-infection of the ALI cultures with swine influenza virus. In addition, the ex vivo porcine precision-cut lung slices (PCLS) model was applied to analyze the role of SLY during a bacterial-bacterial coinfection scenario. Pre-infection of PCLS with Bordetella (B.) bronchiseptica promoted colonization capacities and, consequently, the cytotoxicity of S. suis. Notably, cytotoxicity of S. suis was dependent on the presence of SLY, whereas colonization capacity of S. suis seemed to be independent of the toxin. In conclusion, the results of this study showed that SLY plays a role in pathogen-host cell interactions, as it contributes to S. suis-induced cytotoxicity and to bacterial adherence to respiratory epithelial cells. Furthermore, coinfection with other pathogens can promote infection with S. suis, which may lead to severe systemic disease." @default.
- W3048558840 created "2020-08-18" @default.
- W3048558840 creator A5010629480 @default.
- W3048558840 date "2020-01-01" @default.
- W3048558840 modified "2023-09-23" @default.
- W3048558840 title "Novel insights into the role of the Streptococcus suis toxin suilysin in mono- and coinfections of different porcine respiratory epithelial cell culture systems" @default.
- W3048558840 hasPublicationYear "2020" @default.
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