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- W3048558989 endingPage "643" @default.
- W3048558989 startingPage "633" @default.
- W3048558989 abstract "Antibody-dependent enhancement (ADE) is a mechanism by which the pathogenesis of certain viral infections is enhanced in the presence of sub-neutralizing or cross-reactive non-neutralizing antiviral antibodies. In vitro modelling of ADE has attributed enhanced pathogenesis to Fcγ receptor (FcγR)-mediated viral entry, rather than canonical viral receptor-mediated entry. However, the putative FcγR-dependent mechanisms of ADE overlap with the role of these receptors in mediating antiviral protection in various viral infections, necessitating a detailed understanding of how this diverse family of receptors functions in protection and pathogenesis. Here, we discuss the diversity of immune responses mediated upon FcγR engagement and review the available experimental evidence supporting the role of FcγRs in antiviral protection and pathogenesis through ADE. We explore FcγR engagement in the context of a range of different viral infections, including dengue virus and SARS-CoV, and consider ADE in the context of the ongoing SARS-CoV-2 pandemic." @default.
- W3048558989 created "2020-08-18" @default.
- W3048558989 creator A5007474253 @default.
- W3048558989 creator A5021432635 @default.
- W3048558989 creator A5053073879 @default.
- W3048558989 date "2020-08-11" @default.
- W3048558989 modified "2023-10-11" @default.
- W3048558989 title "The role of IgG Fc receptors in antibody-dependent enhancement" @default.
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