FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3048561563> ?p ?o ?g. }

• W3048561563 endingPage "104949" @default.
• W3048561563 startingPage "104949" @default.
• W3048561563 abstract "Recurrence rates for head and neck squamous cell carcinoma (HNSCC) approach 50% at 5 years. Current staging fails to identify patients with a worse prognosis who might benefit from intensified treatment, which warrants improved prognostic biomarkers. The purpose of this retrospective case study is to identify potential prognostic biomarkers in patients with HNSCC including APE1 (DNA repair/redox gene regulator), NRF2 and PPARGC1A (redox gene regulators), SOD3 and DCN (antioxidant proteins).Differential protein expression between benign, carcinoma in situ (CIS), and invasive HNSCC tissue specimens from 77 patients was assessed using immunohistochemistry. Protein expression was analyzed with multivariate, pair-wise, and Kaplan-Meier survival analyses to identify potential prognostic biomarkers. Utilizing The Cancer Genome Atlas's transcriptome database, pair-wise and survival analysis was performed to identify potential prognostic biomarkers.APE1, NRF2, PPARGC1A, SOD3, and DCN expression in HNSCC in relation to, lymph node invasion, and patient survival were examined. Elevated APE1 protein expression in CIS corresponded with reduced survival (p = 0.0243). Increased APE1 gene expression in stage T4a HNSCC was associated with reduced patient survival (p < 0.015). Increased PPARGC1A in invasive tumor correlated with reduced survival (p = 0.0281). Patients with lymph node invasion at diagnosis had significantly increased APE1 protein in the primary sites (p < 0.05). Patients with poorly differentiated invasive tumors had reduced PPARGC1A in CIS proximal to the invasive tumor and had elevated DCN and SOD3 in proximal benign tissue (p < 0.05).The expression of APE1, DCN, and SOD3 is a potential prognostic signature that identifies patients with worsened survival." @default.
• W3048561563 created "2020-08-18" @default.
• W3048561563 creator A5009670051 @default.
• W3048561563 creator A5021562291 @default.
• W3048561563 creator A5024316557 @default.
• W3048561563 creator A5027413851 @default.
• W3048561563 creator A5030064179 @default.
• W3048561563 creator A5033978885 @default.
• W3048561563 creator A5037989560 @default.
• W3048561563 creator A5042036789 @default.
• W3048561563 creator A5044665651 @default.
• W3048561563 creator A5045291992 @default.
• W3048561563 creator A5070311654 @default.
• W3048561563 creator A5076006520 @default.
• W3048561563 date "2020-12-01" @default.
• W3048561563 modified "2023-10-10" @default.
• W3048561563 title "Evaluation of antioxidant network proteins as novel prognostic biomarkers for head and neck cancer patients" @default.
• W3048561563 cites W1642321690 @default.
• W3048561563 cites W1832442421 @default.
• W3048561563 cites W1864596450 @default.
• W3048561563 cites W1963958144 @default.
• W3048561563 cites W1966033046 @default.
• W3048561563 cites W1986241711 @default.
• W3048561563 cites W2005550821 @default.
• W3048561563 cites W2006952521 @default.
• W3048561563 cites W2007885262 @default.
• W3048561563 cites W2009219948 @default.
• W3048561563 cites W2010468255 @default.
• W3048561563 cites W2012033459 @default.
• W3048561563 cites W2022051063 @default.
• W3048561563 cites W2024689707 @default.
• W3048561563 cites W2027825314 @default.
• W3048561563 cites W2049953507 @default.
• W3048561563 cites W2056736498 @default.
• W3048561563 cites W2061982070 @default.
• W3048561563 cites W2065449346 @default.
• W3048561563 cites W2073300010 @default.
• W3048561563 cites W2074929331 @default.
• W3048561563 cites W2084216648 @default.
• W3048561563 cites W2086717248 @default.
• W3048561563 cites W2099411992 @default.
• W3048561563 cites W2108029083 @default.
• W3048561563 cites W2125697561 @default.
• W3048561563 cites W2138518811 @default.
• W3048561563 cites W2150493124 @default.
• W3048561563 cites W2152525869 @default.
• W3048561563 cites W2206297173 @default.
• W3048561563 cites W2464268084 @default.
• W3048561563 cites W2529121786 @default.
• W3048561563 cites W2558677178 @default.
• W3048561563 cites W2622239853 @default.
• W3048561563 cites W2735916077 @default.
• W3048561563 cites W2746781208 @default.
• W3048561563 doi "https://doi.org/10.1016/j.oraloncology.2020.104949" @default.
• W3048561563 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8256620" @default.
• W3048561563 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32801084" @default.
• W3048561563 hasPublicationYear "2020" @default.
• W3048561563 type Work @default.
• W3048561563 sameAs 3048561563 @default.
• W3048561563 citedByCount "7" @default.
• W3048561563 countsByYear W30485615632021 @default.
• W3048561563 countsByYear W30485615632023 @default.
• W3048561563 crossrefType "journal-article" @default.
• W3048561563 hasAuthorship W3048561563A5009670051 @default.
• W3048561563 hasAuthorship W3048561563A5021562291 @default.
• W3048561563 hasAuthorship W3048561563A5024316557 @default.
• W3048561563 hasAuthorship W3048561563A5027413851 @default.
• W3048561563 hasAuthorship W3048561563A5030064179 @default.
• W3048561563 hasAuthorship W3048561563A5033978885 @default.
• W3048561563 hasAuthorship W3048561563A5037989560 @default.
• W3048561563 hasAuthorship W3048561563A5042036789 @default.
• W3048561563 hasAuthorship W3048561563A5044665651 @default.
• W3048561563 hasAuthorship W3048561563A5045291992 @default.
• W3048561563 hasAuthorship W3048561563A5070311654 @default.
• W3048561563 hasAuthorship W3048561563A5076006520 @default.
• W3048561563 hasBestOaLocation W30485615632 @default.
• W3048561563 hasConcept C121608353 @default.
• W3048561563 hasConcept C126322002 @default.
• W3048561563 hasConcept C142724271 @default.
• W3048561563 hasConcept C143998085 @default.
• W3048561563 hasConcept C193270364 @default.
• W3048561563 hasConcept C204232928 @default.
• W3048561563 hasConcept C2776530083 @default.
• W3048561563 hasConcept C2776833033 @default.
• W3048561563 hasConcept C2780849966 @default.
• W3048561563 hasConcept C502942594 @default.
• W3048561563 hasConcept C71924100 @default.
• W3048561563 hasConceptScore W3048561563C121608353 @default.
• W3048561563 hasConceptScore W3048561563C126322002 @default.
• W3048561563 hasConceptScore W3048561563C142724271 @default.
• W3048561563 hasConceptScore W3048561563C143998085 @default.
• W3048561563 hasConceptScore W3048561563C193270364 @default.
• W3048561563 hasConceptScore W3048561563C204232928 @default.
• W3048561563 hasConceptScore W3048561563C2776530083 @default.
• W3048561563 hasConceptScore W3048561563C2776833033 @default.
• W3048561563 hasConceptScore W3048561563C2780849966 @default.
• W3048561563 hasConceptScore W3048561563C502942594 @default.
• W3048561563 hasConceptScore W3048561563C71924100 @default.

• next