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• W3048561640 abstract "A series of polysubstituted pyrrolidines obtained via ruthenium-catalyzed cascade cyclization of diazo pyruvates and anilines as well as their corresponding pyrrole analogs obtained via dehydration were evaluated for their antiproliferation activities. Pyrrolidines 3h and 3k showed good proliferation inhibitory effects toward 10 cancer cell lines with IC50 values ranging from 2.9 to 16 μM. Furthermore, pyrrolidine 3k induced cell cycle arrest at the G0/G1 phase and time- and dose-dependent cellular apoptosis in both HCT116 and HL60 cells, suggesting that this type of pyrrolidine structure might be a good candidate for future anticancer therapies." @default.
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• W3048561640 date "2020-08-09" @default.
• W3048561640 modified "2023-10-10" @default.
• W3048561640 title "Synthesis and biological evaluation of substituted pyrrolidines and pyrroles as potential anticancer agents" @default.
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• W3048561640 doi "https://doi.org/10.1002/ardp.202000136" @default.
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