FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3048573396> ?p ?o ?g. }

• W3048573396 abstract "Abstract Background Samoa conducted eight nationwide rounds of mass drug administration (MDA) for lymphatic filariasis (LF) between 1999 and 2011, and two targeted rounds in 2015 and 2017 in North West Upolu (NWU), one of three evaluation units (EUs). Transmission Assessment Surveys (TAS) were conducted in 2013 (failed in NWU) and 2017 (all three EUs failed). In 2018, Samoa was the first in the world to distribute nationwide triple-drug MDA using ivermectin, diethylcarbamazine, and albendazole. Surveillance and Monitoring to Eliminate LF and Scabies from Samoa (SaMELFS Samoa) is an operational research program designed to evaluate the effectiveness of triple-drug MDA on LF transmission and scabies prevalence in Samoa, and to compare the usefulness of different indicators of LF transmission. This paper reports results from the 2018 baseline survey and aims to i) investigate antigen (Ag) prevalence and spatial epidemiology, including geographic clustering; ii) compare Ag prevalence between two different age groups (5-9 years versus ≥10 years) as indicators of areas of ongoing transmission; and iii) assess the prevalence of limb lymphedema in those aged ≥15 years. Methods A community-based cluster survey was conducted in 30 randomly selected and five purposively selected clusters (primary sampling units, PSUs), each comprising one or two villages. Participants were recruited through household surveys (age ≥5 years) and convenience surveys (age 5-9 years). Alere™ Filariasis Test Strips (FTS) were used to detect Ag, and prevalence was adjusted for survey design and standardized for age and gender. Adjusted Ag prevalence was estimated for each age group (5-9, ≥10, and all ages ≥5 years) for random and purposive PSUs, and by region. Intraclass correlation (ICC) was used to quantify clustering at regions, PSUs, and households. Results A total of 3940 persons were included (1942 children aged 5-9 years, 1998 persons aged ≥10 years). Adjusted Ag prevalence in all ages ≥5 years in randomly and purposively selected PSUs were 4.0% (95% CI 2.8-5.6%) and 10.0% (95% CI 7.4-13.4%), respectively. In random PSUs, Ag prevalence was lower in those aged 5-9 years (1.3%, 95% CI 0.8-2.1%) than ≥10 years (4.7%, 95% CI 3.1-7.0%), and poorly correlated at the PSU level (R2=0.1459). Adjusted Ag prevalence at PSUs ranged from 0% to 10.3% (95% CI 5.9-17.6%) in randomly selected and 3.8% (95% CI 1.3-10.8%) to 20.0% (95% CI 15.3-25.8%) in purposively selected PSUs. ICC for Ag-positive individuals was higher at households (0.46) compared to PSUs (0.18) and regions (0.01). Conclusions Our study confirmed ongoing transmission of LF in Samoa, in accordance with the 2017 TAS results. Ag prevalence varied significantly between PSUs, and there was poor correlation between prevalence in 5-9 year-olds and older ages, who had threefold higher prevalence. Sampling older age groups would provide more accurate estimates of overall prevalence, and more sensitive for identifying residual hotspots. Higher prevalence in purposively selected PSUs shows local knowledge can help identify at least some hotspots. Author summary Lymphatic filariasis (LF), a disease caused by infection with worms transmitted by mosquitoes, has long been present in Samoa. Since the 1960s, Samoa has attempted to control the disease through many rounds of annual administration of two deworming drugs to the whole population. However, Samoa recently observed that LF transmission was still occurring, prompting mass drug administration (MDA) with three drugs in 2018. Here, we report the baseline survey of an operational research program to evaluate the triple drug MDA. The survey assessed prevalence and geographical distribution of LF in the population, compared prevalence by age groups, and investigated the burden of elephantiasis (swollen limbs caused by long-term LF infection). The study confirmed ongoing transmission, with 4% of those aged ≥5 years showing antigen in their blood as evidence of infection. Antigen prevalence was more than three times higher in those aged ≥10 years (4.7%) than in 5-9 year-old children (1.3%). Infection was highly clustered within households and villages, with up to 20% of residents infected in known hotspot villages. Future surveillance strategies should consider that i) testing older age groups would provide more accurate indication of LF transmission, and ii) local knowledge can help identify transmission hotspots." @default.
• W3048573396 created "2020-08-18" @default.
• W3048573396 creator A5007742429 @default.
• W3048573396 creator A5017856805 @default.
• W3048573396 creator A5019336235 @default.
• W3048573396 creator A5031352764 @default.
• W3048573396 creator A5034599786 @default.
• W3048573396 creator A5048486467 @default.
• W3048573396 creator A5051791096 @default.
• W3048573396 creator A5054857534 @default.
• W3048573396 creator A5058569108 @default.
• W3048573396 creator A5061008460 @default.
• W3048573396 creator A5068058892 @default.
• W3048573396 date "2020-08-13" @default.
• W3048573396 modified "2023-09-27" @default.
• W3048573396 title "Lymphatic Filariasis Epidemiology in Samoa in 2018: Geographic Clustering and Higher Antigen Prevalence in Older Age Groups" @default.
• W3048573396 cites W1974712797 @default.
• W3048573396 cites W1985338680 @default.
• W3048573396 cites W1986532204 @default.
• W3048573396 cites W1988358693 @default.
• W3048573396 cites W2013225830 @default.
• W3048573396 cites W2016278466 @default.
• W3048573396 cites W2028785633 @default.
• W3048573396 cites W2040916526 @default.
• W3048573396 cites W2060965306 @default.
• W3048573396 cites W2092022025 @default.
• W3048573396 cites W2106774610 @default.
• W3048573396 cites W2165295609 @default.
• W3048573396 cites W2181101964 @default.
• W3048573396 cites W2342353367 @default.
• W3048573396 cites W2401258102 @default.
• W3048573396 cites W2548762493 @default.
• W3048573396 cites W2626576487 @default.
• W3048573396 cites W2740236843 @default.
• W3048573396 cites W2754061502 @default.
• W3048573396 cites W2766081991 @default.
• W3048573396 cites W2793236301 @default.
• W3048573396 cites W2807314713 @default.
• W3048573396 cites W2883070395 @default.
• W3048573396 cites W2956534994 @default.
• W3048573396 cites W3001823514 @default.
• W3048573396 cites W3011611414 @default.
• W3048573396 cites W3015757145 @default.
• W3048573396 cites W3020004539 @default.
• W3048573396 cites W3024836883 @default.
• W3048573396 cites W3109725876 @default.
• W3048573396 doi "https://doi.org/10.1101/2020.08.10.20171298" @default.
• W3048573396 hasPublicationYear "2020" @default.
• W3048573396 type Work @default.
• W3048573396 sameAs 3048573396 @default.
• W3048573396 citedByCount "1" @default.
• W3048573396 countsByYear W30485733962020 @default.
• W3048573396 crossrefType "posted-content" @default.
• W3048573396 hasAuthorship W3048573396A5007742429 @default.
• W3048573396 hasAuthorship W3048573396A5017856805 @default.
• W3048573396 hasAuthorship W3048573396A5019336235 @default.
• W3048573396 hasAuthorship W3048573396A5031352764 @default.
• W3048573396 hasAuthorship W3048573396A5034599786 @default.
• W3048573396 hasAuthorship W3048573396A5048486467 @default.
• W3048573396 hasAuthorship W3048573396A5051791096 @default.
• W3048573396 hasAuthorship W3048573396A5054857534 @default.
• W3048573396 hasAuthorship W3048573396A5058569108 @default.
• W3048573396 hasAuthorship W3048573396A5061008460 @default.
• W3048573396 hasAuthorship W3048573396A5068058892 @default.
• W3048573396 hasBestOaLocation W30485733961 @default.
• W3048573396 hasConcept C107130276 @default.
• W3048573396 hasConcept C119599485 @default.
• W3048573396 hasConcept C126322002 @default.
• W3048573396 hasConcept C127413603 @default.
• W3048573396 hasConcept C141071460 @default.
• W3048573396 hasConcept C144024400 @default.
• W3048573396 hasConcept C149923435 @default.
• W3048573396 hasConcept C165901193 @default.
• W3048573396 hasConcept C203014093 @default.
• W3048573396 hasConcept C2776158911 @default.
• W3048573396 hasConcept C2777065887 @default.
• W3048573396 hasConcept C2777411658 @default.
• W3048573396 hasConcept C2777499811 @default.
• W3048573396 hasConcept C2777629521 @default.
• W3048573396 hasConcept C2780133432 @default.
• W3048573396 hasConcept C2908647359 @default.
• W3048573396 hasConcept C42972112 @default.
• W3048573396 hasConcept C71924100 @default.
• W3048573396 hasConcept C761482 @default.
• W3048573396 hasConcept C99454951 @default.
• W3048573396 hasConceptScore W3048573396C107130276 @default.
• W3048573396 hasConceptScore W3048573396C119599485 @default.
• W3048573396 hasConceptScore W3048573396C126322002 @default.
• W3048573396 hasConceptScore W3048573396C127413603 @default.
• W3048573396 hasConceptScore W3048573396C141071460 @default.
• W3048573396 hasConceptScore W3048573396C144024400 @default.
• W3048573396 hasConceptScore W3048573396C149923435 @default.
• W3048573396 hasConceptScore W3048573396C165901193 @default.
• W3048573396 hasConceptScore W3048573396C203014093 @default.
• W3048573396 hasConceptScore W3048573396C2776158911 @default.
• W3048573396 hasConceptScore W3048573396C2777065887 @default.
• W3048573396 hasConceptScore W3048573396C2777411658 @default.
• W3048573396 hasConceptScore W3048573396C2777499811 @default.
• W3048573396 hasConceptScore W3048573396C2777629521 @default.
• W3048573396 hasConceptScore W3048573396C2780133432 @default.

• next