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• W3048581321 endingPage "136917" @default.
• W3048581321 startingPage "136917" @default.
• W3048581321 abstract "It is critical to monitor glucose level in the health management of diabetes patients. In this work, we developed a polylactic acid (PLA) based microneedle (MN) based glucose sensor. This PLA MN base was then coated with gold as the conductive layer, overoxidized polypyrrole (OPPy), gold nanoparticles (AuNPs), glucose oxidase (GOx), and Nafion. In vitro test, this glucose MN sensor showed a linear range from 0 to 2.6 mM with a sensitivity of 8.09 μA/mM, limit of detection (LOD) of 40 μM and not affected by ascorbic acid (AA), urea, glycine (Gly), acetaminophen (AP) in phosphate buffer solution,. The composite of OPPy and AuNPs improved the sensor sensitivity and GOx adhesive ability to the electrode. Nafion film protected the sensor from interfering substances. In the stability test, the sensor exhibited a stable monitoring sensitivity after 2 weeks. This work demonstrates this MN sensor has the potential to be applied in minimally invasive glucose monitoring." @default.
• W3048581321 created "2020-08-18" @default.
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• W3048581321 date "2020-10-01" @default.
• W3048581321 modified "2023-10-03" @default.
• W3048581321 title "A gold nanoparticles deposited polymer microneedle enzymatic biosensor for glucose sensing" @default.
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• W3048581321 doi "https://doi.org/10.1016/j.electacta.2020.136917" @default.
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