FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3048582409> ?p ?o ?g. }

• W3048582409 endingPage "1806" @default.
• W3048582409 startingPage "1791" @default.
• W3048582409 abstract "Objective Determine whether common migraine comorbidities affect the efficacy and safety of lasmiditan, a 5-HT1F receptor agonist approved in the United States for the acute treatment of migraine.Methods In SPARTAN and SAMURAI (double-blind Phase 3 clinical trials), patients with migraine were randomized to oral lasmiditan 50 mg (SPARTAN only), 100mg, 200 mg, or placebo. Lasmiditan increased the proportion of pain-free and most bothersome symptom (MBS)-free patients at 2 h after dose compared with placebo. Most common treatment-emergent adverse events (TEAEs) were dizziness, paraesthesia, somnolence, fatigue, nausea, muscular weakness, and hypoesthesia. Based upon literature review of common migraine comorbidities, Anxiety, Allergy, Bronchial, Cardiac, Depression, Fatigue, Gastrointestinal, Hormonal, Musculoskeletal/Pain, Neurological, Obesity, Sleep, and Vascular Comorbidity Groups were created. Using pooled results, efficacy and TEAEs were assessed to compare patients with or without a given common migraine comorbidity. To compare treatment groups, p-values were calculated for treatment-by-subgroup interaction, based on logistic regression with treatment-by-comorbidity condition status (Yes/No) as the interaction term; study, treatment group, and comorbidity condition status (Yes/No) were covariates. Differential treatment effect based upon comorbidity status was also examined. Trial registration at clinicaltrials.gov: SAMURAI (NCT02439320) and SPARTAN (NCT02605174).Results Across all the Comorbidity Groups, with the potential exception of fatigue, treatment-by-subgroup interaction analyses did not provide evidence of a lasmiditan-driven lasmiditan versus placebo differential treatment effect dependent on Yes versus No comorbidity subgroup for either efficacy or TEAE assessments.Conclusions The efficacy and safety of lasmiditan for treatment of individual migraine attacks appear to be independent of comorbid conditions." @default.
• W3048582409 created "2020-08-18" @default.
• W3048582409 creator A5012905064 @default.
• W3048582409 creator A5036999043 @default.
• W3048582409 creator A5081661447 @default.
• W3048582409 creator A5088641256 @default.
• W3048582409 date "2020-10-06" @default.
• W3048582409 modified "2023-09-30" @default.
• W3048582409 title "Lasmiditan in patients with common migraine comorbidities: a <i>post hoc</i> efficacy and safety analysis of two phase 3 randomized clinical trials" @default.
• W3048582409 cites W1511619400 @default.
• W3048582409 cites W1523928303 @default.
• W3048582409 cites W1577793440 @default.
• W3048582409 cites W1824012089 @default.
• W3048582409 cites W1831523544 @default.
• W3048582409 cites W1844281459 @default.
• W3048582409 cites W1964049435 @default.
• W3048582409 cites W1966928156 @default.
• W3048582409 cites W1968354217 @default.
• W3048582409 cites W1970602512 @default.
• W3048582409 cites W1971860860 @default.
• W3048582409 cites W1973158184 @default.
• W3048582409 cites W1973174800 @default.
• W3048582409 cites W1974242712 @default.
• W3048582409 cites W1976811898 @default.
• W3048582409 cites W1981733715 @default.
• W3048582409 cites W1982781774 @default.
• W3048582409 cites W1984032310 @default.
• W3048582409 cites W1984226430 @default.
• W3048582409 cites W1984633917 @default.
• W3048582409 cites W1986857614 @default.
• W3048582409 cites W1991070911 @default.
• W3048582409 cites W1993381751 @default.
• W3048582409 cites W1993517217 @default.
• W3048582409 cites W1994796020 @default.
• W3048582409 cites W1996295044 @default.
• W3048582409 cites W1997779537 @default.
• W3048582409 cites W2000830490 @default.
• W3048582409 cites W2002233732 @default.
• W3048582409 cites W2002281336 @default.
• W3048582409 cites W2004231202 @default.
• W3048582409 cites W2005151642 @default.
• W3048582409 cites W2007676816 @default.
• W3048582409 cites W2008082442 @default.
• W3048582409 cites W2009567596 @default.
• W3048582409 cites W2010803685 @default.
• W3048582409 cites W2012296137 @default.
• W3048582409 cites W2012658494 @default.
• W3048582409 cites W2013757953 @default.
• W3048582409 cites W2014007575 @default.
• W3048582409 cites W2015846758 @default.
• W3048582409 cites W2018931075 @default.
• W3048582409 cites W2018995778 @default.
• W3048582409 cites W2019270412 @default.
• W3048582409 cites W2019581824 @default.
• W3048582409 cites W2020336779 @default.
• W3048582409 cites W2020785574 @default.
• W3048582409 cites W2020792474 @default.
• W3048582409 cites W2021504239 @default.
• W3048582409 cites W2023125215 @default.
• W3048582409 cites W2025395795 @default.
• W3048582409 cites W2027764851 @default.
• W3048582409 cites W2028310086 @default.
• W3048582409 cites W2028870364 @default.
• W3048582409 cites W2029122933 @default.
• W3048582409 cites W2031601423 @default.
• W3048582409 cites W2031895775 @default.
• W3048582409 cites W2032209206 @default.
• W3048582409 cites W2032988801 @default.
• W3048582409 cites W2035473688 @default.
• W3048582409 cites W2035516765 @default.
• W3048582409 cites W2036259040 @default.
• W3048582409 cites W2036344281 @default.
• W3048582409 cites W2036354453 @default.
• W3048582409 cites W2036621380 @default.
• W3048582409 cites W2039189807 @default.
• W3048582409 cites W2039428523 @default.
• W3048582409 cites W2042314792 @default.
• W3048582409 cites W2042850712 @default.
• W3048582409 cites W2044257401 @default.
• W3048582409 cites W2044520295 @default.
• W3048582409 cites W2045032027 @default.
• W3048582409 cites W2046048374 @default.
• W3048582409 cites W2047385158 @default.
• W3048582409 cites W2047973317 @default.
• W3048582409 cites W2048326181 @default.
• W3048582409 cites W2049298359 @default.
• W3048582409 cites W2052916272 @default.
• W3048582409 cites W2054671432 @default.
• W3048582409 cites W2054898271 @default.
• W3048582409 cites W2058678855 @default.
• W3048582409 cites W2059242760 @default.
• W3048582409 cites W2061546202 @default.
• W3048582409 cites W2064582039 @default.
• W3048582409 cites W2069501897 @default.
• W3048582409 cites W2070528905 @default.
• W3048582409 cites W2075315440 @default.
• W3048582409 cites W2078644283 @default.
• W3048582409 cites W2079138174 @default.

• next