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• W3048582952 abstract "Transmembrane B cell lymphoma 2-associated X protein inhibitor motif-containing (TMBIM) 6, a Ca2+ channel-like protein, is highly up-regulated in several cancer types. Here, we show that TMBIM6 is closely associated with survival in patients with cervical, breast, lung, and prostate cancer. TMBIM6 deletion or knockdown suppresses primary tumor growth. Further, mTORC2 activation is up-regulated by TMBIM6 and stimulates glycolysis, protein synthesis, and the expression of lipid synthesis genes and glycosylated proteins. Moreover, ER-leaky Ca2+ from TMBIM6, a unique characteristic, is shown to affect mTORC2 assembly and its association with ribosomes. In addition, we identify that the BIA compound, a potentialTMBIM6 antagonist, prevents TMBIM6 binding to mTORC2, decreases mTORC2 activity, and also regulates TMBIM6-leaky Ca2+, further suppressing tumor formation and progression in cancer xenograft models. This previously unknown signaling cascade in which mTORC2 activity is enhanced via the interaction with TMBIM6 provides potential therapeutic targets for various malignancies." @default.
• W3048582952 created "2020-08-18" @default.
• W3048582952 creator A5014699929 @default.
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• W3048582952 date "2020-08-11" @default.
• W3048582952 modified "2023-10-18" @default.
• W3048582952 title "TMBIM6/BI-1 contributes to cancer progression through assembly with mTORC2 and AKT activation" @default.
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• W3048582952 doi "https://doi.org/10.1038/s41467-020-17802-4" @default.
• W3048582952 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7419509" @default.
• W3048582952 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32782388" @default.
• W3048582952 hasPublicationYear "2020" @default.
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