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- W3048583225 abstract "Significance Epigenetic regulation serves as the basis on which multicellular organisms differentiate genetically identical cells into various cell types, and aberrations in epigenetic modifications lead to a range of diseases. The specific biological mechanisms behind the heritability and maintenance of epigenetic modifications are currently not well understood. We develop a predictive theoretical model of the interplay between the proteins that control chromosomal compaction and those that confer posttranslational modifications to histone proteins within chromosomal DNA. Our model is built on the experimentally observed behavior for these individual biological contributions, resulting in a predictive framework that captures a robust mechanism for epigenetic heritability." @default.
- W3048583225 created "2020-08-18" @default.
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- W3048583225 date "2020-08-10" @default.
- W3048583225 modified "2023-10-14" @default.
- W3048583225 title "Physical modeling of the heritability and maintenance of epigenetic modifications" @default.
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- W3048583225 doi "https://doi.org/10.1073/pnas.1920499117" @default.
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