FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3048585833> ?p ?o ?g. }

• W3048585833 endingPage "744" @default.
• W3048585833 startingPage "744" @default.
• W3048585833 abstract "Rosmarinic acid (RosA), an important polyphenol, is known for its antioxidant and anti-inflammatory activities. However, its application in theranostics has been rarely reported. Therefore, a new single-molecule anti-inflammatory theranostic compound containing RosA would be of great interest. A gadolinium (Gd) complex of 1,4,7,10-tetraazacyclododecane-1,4,7-trisacetic acid (DO3A) and RosA (Gd(DO3A-RosA)(H2O)) was synthesized and examined for use as a single-molecule theranostic agent. Its kinetic stability is comparable to that of clinically used macrocyclic magnetic resonance imaging contrast agents. In addition, its relaxivity is higher than that of structurally analogous Gd-BT-DO3A. This agent was evaluated for inflammatory targeting magnetic resonance contrast and showed strong and prolonged enhancement of imaging in inflamed tissues of mice. The theranostic agent also possesses antioxidant and anti-inflammatory activities, as evidenced by reactive oxygen species scavenging, superoxide dismutase activity, and inflammatory factors. The novel RosA-conjugated Gd complex is a promising theranostic agent for the imaging of inflamed tissues, as well as for the treatment of inflammation and oxidative stress." @default.
• W3048585833 created "2020-08-18" @default.
• W3048585833 creator A5037193058 @default.
• W3048585833 creator A5050576396 @default.
• W3048585833 creator A5069818368 @default.
• W3048585833 creator A5079165491 @default.
• W3048585833 creator A5089955705 @default.
• W3048585833 date "2020-08-13" @default.
• W3048585833 modified "2023-09-26" @default.
• W3048585833 title "Gd-Complex of a Rosmarinic Acid Conjugate as an Anti-Inflammatory Theranostic Agent via Reactive Oxygen Species Scavenging" @default.
• W3048585833 cites W1533990758 @default.
• W3048585833 cites W1906337168 @default.
• W3048585833 cites W1979711098 @default.
• W3048585833 cites W1986463549 @default.
• W3048585833 cites W1993638883 @default.
• W3048585833 cites W2000239317 @default.
• W3048585833 cites W2003542725 @default.
• W3048585833 cites W2004566177 @default.
• W3048585833 cites W2017929299 @default.
• W3048585833 cites W2023617887 @default.
• W3048585833 cites W2024992865 @default.
• W3048585833 cites W2036509107 @default.
• W3048585833 cites W2044957933 @default.
• W3048585833 cites W2046005857 @default.
• W3048585833 cites W2056879548 @default.
• W3048585833 cites W2064004368 @default.
• W3048585833 cites W2069789444 @default.
• W3048585833 cites W2072398064 @default.
• W3048585833 cites W2085713699 @default.
• W3048585833 cites W2108078553 @default.
• W3048585833 cites W2114476260 @default.
• W3048585833 cites W2115094304 @default.
• W3048585833 cites W2116060738 @default.
• W3048585833 cites W2123098050 @default.
• W3048585833 cites W2126894693 @default.
• W3048585833 cites W2129537013 @default.
• W3048585833 cites W2134987073 @default.
• W3048585833 cites W2140987918 @default.
• W3048585833 cites W2148438596 @default.
• W3048585833 cites W2164993228 @default.
• W3048585833 cites W2171271249 @default.
• W3048585833 cites W2173709855 @default.
• W3048585833 cites W2175961304 @default.
• W3048585833 cites W2230184388 @default.
• W3048585833 cites W2263023695 @default.
• W3048585833 cites W2282124923 @default.
• W3048585833 cites W2314882532 @default.
• W3048585833 cites W2315977976 @default.
• W3048585833 cites W2325529136 @default.
• W3048585833 cites W2519076288 @default.
• W3048585833 cites W2520325125 @default.
• W3048585833 cites W2521574223 @default.
• W3048585833 cites W2564673641 @default.
• W3048585833 cites W2725436406 @default.
• W3048585833 cites W2735639669 @default.
• W3048585833 cites W2736053083 @default.
• W3048585833 cites W2789924901 @default.
• W3048585833 cites W2791276468 @default.
• W3048585833 cites W2796635366 @default.
• W3048585833 cites W2803317431 @default.
• W3048585833 cites W2890013071 @default.
• W3048585833 cites W2899052178 @default.
• W3048585833 cites W2953839906 @default.
• W3048585833 cites W3007272556 @default.
• W3048585833 cites W3033572747 @default.
• W3048585833 cites W3038217103 @default.
• W3048585833 cites W3038285114 @default.
• W3048585833 cites W3207702032 @default.
• W3048585833 cites W4235517036 @default.
• W3048585833 doi "https://doi.org/10.3390/antiox9080744" @default.
• W3048585833 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7464237" @default.
• W3048585833 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32823673" @default.
• W3048585833 hasPublicationYear "2020" @default.
• W3048585833 type Work @default.
• W3048585833 sameAs 3048585833 @default.
• W3048585833 citedByCount "6" @default.
• W3048585833 countsByYear W30485858332021 @default.
• W3048585833 countsByYear W30485858332022 @default.
• W3048585833 countsByYear W30485858332023 @default.
• W3048585833 crossrefType "journal-article" @default.
• W3048585833 hasAuthorship W3048585833A5037193058 @default.
• W3048585833 hasAuthorship W3048585833A5050576396 @default.
• W3048585833 hasAuthorship W3048585833A5069818368 @default.
• W3048585833 hasAuthorship W3048585833A5079165491 @default.
• W3048585833 hasAuthorship W3048585833A5089955705 @default.
• W3048585833 hasBestOaLocation W30485858331 @default.
• W3048585833 hasConcept C112613896 @default.
• W3048585833 hasConcept C12554922 @default.
• W3048585833 hasConcept C134306372 @default.
• W3048585833 hasConcept C178790620 @default.
• W3048585833 hasConcept C185592680 @default.
• W3048585833 hasConcept C197336794 @default.
• W3048585833 hasConcept C2775838275 @default.
• W3048585833 hasConcept C2776151105 @default.
• W3048585833 hasConcept C2778004101 @default.
• W3048585833 hasConcept C2778771215 @default.
• W3048585833 hasConcept C2778978742 @default.
• W3048585833 hasConcept C2779703632 @default.

• next