Matches in SemOpenAlex for { <https://semopenalex.org/work/W3048586051> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W3048586051 endingPage "674" @default.
- W3048586051 startingPage "667" @default.
- W3048586051 abstract "Objective To compare the live birth rate and cost effectiveness of artificial cycle‐prepared frozen embryo transfer (AC‐FET) with or without GnRH agonist (GnRH‐a) pretreatment for women with polycystic ovary syndrome (PCOS). Design Open‐label, randomised, controlled trial. Setting Reproductive centre of a university‐affiliated hospital. Sample A total of 343 women with PCOS, aged 24–40 years, scheduled for AC‐FET and receiving no more than two blastocysts. Methods The pretreatment group ( n = 172) received GnRH‐a pretreatment and the control group ( n = 171) did not. Analysis followed the intention‐to‐treat (ITT) principle. Main outcome measures The primary outcome measure was live birth rate. Secondary outcome measures included clinical pregnancy rate, implantation rate, early pregnancy loss rate and direct treatment costs per FET cycle. Results Among the 343 women randomised, 330 (96.2%) underwent embryo transfer and 328 (95.6%) completed the protocols. Live birth rate according to ITT did not differ between the pretreatment and control groups [85/172 (49.4%) versus 92/171 (53.8%), absolute rate difference −4.4%, 95% CI −10.8% to 2.0% ( P = 0.45). Implantation rate, clinical pregnancy rate and early pregnancy loss rate also did not differ between groups, but median direct cost per FET cycle was significantly higher in the pretreatment group (7799.2 versus 4438.9 RMB, OR = 1.9, 95%CI 1.2–3.4, P < 0.001). Median direct cost per live birth was also significantly higher in the pretreatment group (15663.1 versus 8189.9 RMB, odds ratio [OR] = 1.9, 95% CI 1.2–3.8, P < 0.001). Conclusions Pretreatment with GnRH‐a does not improve pregnancy outcomes for women with PCOS receiving AC‐FET, but significantly increases patient cost. Tweetable abstract For women with PCOS, artificial cycle‐prepared FET with GnRH agonist pretreatment provides no pregnancy outcome benefit but incurs higher cost." @default.
- W3048586051 created "2020-08-18" @default.
- W3048586051 creator A5000044234 @default.
- W3048586051 creator A5016148464 @default.
- W3048586051 creator A5038417134 @default.
- W3048586051 creator A5060413120 @default.
- W3048586051 creator A5071590370 @default.
- W3048586051 creator A5084606295 @default.
- W3048586051 date "2020-09-06" @default.
- W3048586051 modified "2023-10-12" @default.
- W3048586051 title "Pregnancy outcome and cost‐effectiveness comparisons of artificial cycle‐prepared frozen embryo transfer with or without GnRH agonist pretreatment for polycystic ovary syndrome: a randomised controlled trial" @default.
- W3048586051 cites W2086268895 @default.
- W3048586051 cites W2121178738 @default.
- W3048586051 cites W2142443059 @default.
- W3048586051 cites W2171733571 @default.
- W3048586051 cites W2310496901 @default.
- W3048586051 cites W2505179618 @default.
- W3048586051 cites W2526935097 @default.
- W3048586051 cites W2605875465 @default.
- W3048586051 cites W2734470509 @default.
- W3048586051 cites W2740355033 @default.
- W3048586051 cites W2888151207 @default.
- W3048586051 cites W2900886341 @default.
- W3048586051 cites W2946465202 @default.
- W3048586051 cites W2980775366 @default.
- W3048586051 cites W4256605237 @default.
- W3048586051 cites W2919230355 @default.
- W3048586051 doi "https://doi.org/10.1111/1471-0528.16461" @default.
- W3048586051 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32783367" @default.
- W3048586051 hasPublicationYear "2020" @default.
- W3048586051 type Work @default.
- W3048586051 sameAs 3048586051 @default.
- W3048586051 citedByCount "13" @default.
- W3048586051 countsByYear W30485860512021 @default.
- W3048586051 countsByYear W30485860512022 @default.
- W3048586051 countsByYear W30485860512023 @default.
- W3048586051 crossrefType "journal-article" @default.
- W3048586051 hasAuthorship W3048586051A5000044234 @default.
- W3048586051 hasAuthorship W3048586051A5016148464 @default.
- W3048586051 hasAuthorship W3048586051A5038417134 @default.
- W3048586051 hasAuthorship W3048586051A5060413120 @default.
- W3048586051 hasAuthorship W3048586051A5071590370 @default.
- W3048586051 hasAuthorship W3048586051A5084606295 @default.
- W3048586051 hasConcept C126322002 @default.
- W3048586051 hasConcept C131872663 @default.
- W3048586051 hasConcept C160099875 @default.
- W3048586051 hasConcept C2776537878 @default.
- W3048586051 hasConcept C2777391703 @default.
- W3048586051 hasConcept C2777688143 @default.
- W3048586051 hasConcept C2778279030 @default.
- W3048586051 hasConcept C2779234561 @default.
- W3048586051 hasConcept C29456083 @default.
- W3048586051 hasConcept C3018442814 @default.
- W3048586051 hasConcept C500014431 @default.
- W3048586051 hasConcept C511355011 @default.
- W3048586051 hasConcept C54355233 @default.
- W3048586051 hasConcept C71924100 @default.
- W3048586051 hasConcept C86803240 @default.
- W3048586051 hasConceptScore W3048586051C126322002 @default.
- W3048586051 hasConceptScore W3048586051C131872663 @default.
- W3048586051 hasConceptScore W3048586051C160099875 @default.
- W3048586051 hasConceptScore W3048586051C2776537878 @default.
- W3048586051 hasConceptScore W3048586051C2777391703 @default.
- W3048586051 hasConceptScore W3048586051C2777688143 @default.
- W3048586051 hasConceptScore W3048586051C2778279030 @default.
- W3048586051 hasConceptScore W3048586051C2779234561 @default.
- W3048586051 hasConceptScore W3048586051C29456083 @default.
- W3048586051 hasConceptScore W3048586051C3018442814 @default.
- W3048586051 hasConceptScore W3048586051C500014431 @default.
- W3048586051 hasConceptScore W3048586051C511355011 @default.
- W3048586051 hasConceptScore W3048586051C54355233 @default.
- W3048586051 hasConceptScore W3048586051C71924100 @default.
- W3048586051 hasConceptScore W3048586051C86803240 @default.
- W3048586051 hasFunder F4320321001 @default.
- W3048586051 hasFunder F4320321160 @default.
- W3048586051 hasIssue "4" @default.
- W3048586051 hasLocation W30485860511 @default.
- W3048586051 hasOpenAccess W3048586051 @default.
- W3048586051 hasPrimaryLocation W30485860511 @default.
- W3048586051 hasRelatedWork W1987200979 @default.
- W3048586051 hasRelatedWork W2102804384 @default.
- W3048586051 hasRelatedWork W2107688507 @default.
- W3048586051 hasRelatedWork W2355835144 @default.
- W3048586051 hasRelatedWork W2396234584 @default.
- W3048586051 hasRelatedWork W2915105102 @default.
- W3048586051 hasRelatedWork W3005697888 @default.
- W3048586051 hasRelatedWork W3048586051 @default.
- W3048586051 hasRelatedWork W3090809081 @default.
- W3048586051 hasRelatedWork W4322505009 @default.
- W3048586051 hasVolume "128" @default.
- W3048586051 isParatext "false" @default.
- W3048586051 isRetracted "false" @default.
- W3048586051 magId "3048586051" @default.
- W3048586051 workType "article" @default.