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- W3048587205 endingPage "839" @default.
- W3048587205 startingPage "833" @default.
- W3048587205 abstract "Acne is the most common skin disease in adolescent Westernized populations. Several data support the involvement of the mammalian target of rapamycin complex 1 (mTORC1) signalling in the interplay between androgens, insulin, insulin-like growth factor (IGF1) and high-glycaemic index diet in acne. The peroxisome proliferator-activated receptor γ (PPARγ) is involved in both differentiation and anti-inflammatory response. Low differentiated sebocytes showed decreased expression of PPARγ and increased level of insulin and IGF-1 receptors, resulting in the production of acne-like sebum and inflammatory mediators. In this viewpoint, we discuss how in acne the dysregulation of proliferation and differentiation processes in sebocytes and keratinocytes may be associated with altered response to androgens and other hormones, such as insulin or IGF-1. Moreover, we propose PPARγ modulation as an innovative therapeutic approach to normalize sebocyte differentiation process, interfering with the different mechanisms involved in altered pilosebaceous unit." @default.
- W3048587205 created "2020-08-18" @default.
- W3048587205 creator A5018150717 @default.
- W3048587205 creator A5036012035 @default.
- W3048587205 creator A5081828201 @default.
- W3048587205 creator A5090185786 @default.
- W3048587205 date "2020-09-01" @default.
- W3048587205 modified "2023-10-01" @default.
- W3048587205 title "Acne as an altered dermato‐endocrine response problem" @default.
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